WDR35

Official Full Name

WD repeat domain 35
Background

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. Two patients with Sensenbrenner syndrome / cranioectodermal dysplasia (CED) were identified with mutations in this gene, consistent with a possible ciliary function.
Synonyms

WDR35; WD repeat domain 35; WD repeat-containing protein 35; KIAA1336; MGC33196; naofen; intraflagellar transport protein 121 homolog; CED2;

Species	Cat.#	Product name	Source (Host)	Tag	Price
Mouse	WDR35-18467M	Recombinant Mouse WDR35 Protein	Mammalian Cell	His	Inquiry
Mouse	WDR35-10129M	Recombinant Mouse WDR35 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Mouse	WDR35-10129M-B	Recombinant Mouse WDR35 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Zebrafish	WDR35-7338Z	Recombinant Zebrafish WDR35	Mammalian Cell	His	Inquiry

Involved Pathway
Protein Function
Interacting Protein

WDR35 involved in several pathways and played different roles in them. We selected most pathways WDR35 participated on our site, such as Assembly of the primary cilium, Hedgehog off state, Intraflagellar transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with WDR35 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Assembly of the primary cilium	SSTR3;DYNC1H1;DYNLRB1;CP110;MKS1;TTC21B;CEP72;CEP89;CEP290
Hedgehog off state	KIF7;BBS13;OFD1;IFT172;TULP3;IFT122;IFT88;WDR19;MKS1
Intraflagellar transport	IFT88;IFT27;TCTEX1D2;IFT74;IFT122;WDR19;TTC30B;TTC30A;DYNLL2A
Organelle biogenesis and maintenance	MRPL44;PKD1;PKD2;MRPL41;CNGA2;MKS1;MRPL42;GADD45GIP1;EXOC5
Signal Transduction	GPR120;IQGAP3;CALCB;NEDD8L;NMT1B;DNAL4A;RHPN1;PLEKHG2;MDKA
Signaling by Hedgehog	RPGRIP1L;WDR35;CDC73;HHAT;TULP3;GPR161;SPOP;WDR19;DISP2

WDR35 has several biochemical functions, for example, phosphatidylinositol binding. Some of the functions are cooperated with other proteins, some of the functions could acted by WDR35 itself. We selected most functions WDR35 had, and list some proteins which have the same functions with WDR35. You can find most of the proteins on our site.

Function	Related Protein
phosphatidylinositol binding	NISCH;PLD1A;SNX8;ZCCHC2;HIP1R;SNX1;PASK;PLD1;TUB

WDR35 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WDR35 here. Most of them are supplied by our site. Hope this information will be useful for your research of WDR35.