• Official Full Name

    tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide

  • Overview

    14-3-3 proteins are highly conserved proteins which play a role in both signal transduction and progression through the cell cycle by binding to and regulating several different proteins. 14-3-3 proteins activate tyrosine and tryptophan hydroxylases and protein kinase C. They mediate signal transduction by binding to phosphoserine-containing proteins. There are at least 7 mammalian isoforms: alpha, beta, gamma, delta, epsilon, zeta, and eta. An eighth subtype, termed theta has been found in rat brain. The 14-3-3 proteins exists in vitro and in vivo as either homo- or heterodimers which interact via their N-terminal domains and are subject to phosphorylation by protein kinase C. 14-3-3 proteins are localized in the cytoplasm of neurons in the cerebral cortex and are axonally transported to the nerve terminals. They may be present at lower levels in various other eukaryotic tissues. Northern blot analysis has shown expression of the eta chain in cultured cell lines derived from various tumors.
  • Synonyms

    YWHAZ; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide; tyrosine 3 monooxygenase/tryptophan 5 monooxygenase activation protein, delta polypeptide , YWHAD; 14-3-3 protein zeta/delta; 14 3 3 delta; 14 3 3 zeta; KCIP;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Yeast
  • C
  • Myc
  • DDK
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • SUMO
  • N/A
  • N
  • T7|His
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human YWHAZ-104H Recombinant Human Tyrosine 3-monooxygenase/ Tryptophan 5-monooxygenase Activation Protein, Zeta Polypeptide, His-tagged E.coli His
Human YWHAZ-4901H Recombinant Human Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein, Zeta Polypeptide E.coli N/A
Human YWHAZ-3776H Recombinant Human YWHAZ, GST-tagged E.coli GST 1-245aa
Human YWHAZ-831H Recombinant Human YWHAZ Protein, His-tagged E.coli His 2 - 245
Human YWHAZ-4900H Recombinant Human Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein, Zeta Polypeptide, GST-tagged E.coli GST
Human YWHAZ-203H Recombinant Human YWHAZ protein, T7/His-tagged E.coli T7/His
Human YWHAZ-153H Recombinant Human YWHAG Protein, His-tagged Insect Cell His
Human YWHAZ-229HCL Recombinant Human YWHAZ 293 Cell Lysate HEK293 N/A
Human YWHAZ-5831H Recombinant Human YWHAZ protein, His-tagged Yeast His 1-245 aa
Human YWHAZ-843H Recombinant Human YWHAZ Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human YWHAZ-226H Recombinant Human YWHAZ Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human YWHAZ-2861H Recombinant Human YWHAZ Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human YWHAZ-2381H Recombinant Human YWHAZ Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human YWHAZ-2799H Recombinant Human YWHAZ Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human YWHAZ-3779H Recombinant Human YWHAZ protein, His-GST-tagged E.coli His/GST 133-212aa
Human YWHAZ-467HFL Recombinant Full Length Human YWHAZ Protein, C-Flag-tagged Mammalian cells Flag
Human YWHAZ-2381H-B Recombinant Human YWHAZ Protein Pre-coupled Magnetic Beads HEK293
Human YWHAZ-6580H Recombinant Human YWHAZ Protein (Met1-Asn245), N-His tagged E.coli N-His Met1-Asn245
Mouse Ywhaz-152M Recombinant Mouse Ywhaz Protein, His-tagged Insect Cell His
Mouse YWHAZ-18687M Recombinant Mouse YWHAZ Protein Mammalian Cell His
Mouse YWHAZ-10271M Recombinant Mouse YWHAZ Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Ywhaz-3780M Recombinant Mouse Ywhaz protein, His-SUMO-tagged E.coli His-SUMO 1-245aa
Mouse Ywhaz-7044M Recombinant Mouse Ywhaz Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse YWHAZ-10271M-B Recombinant Mouse YWHAZ Protein Pre-coupled Magnetic Beads HEK293
Rat YWHAZ-6642R Recombinant Rat YWHAZ Protein Mammalian Cell His
Rat YWHAZ-6298R Recombinant Rat YWHAZ Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat YWHAZ-6298R-B Recombinant Rat YWHAZ Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque YWHAZ-5249R Recombinant Rhesus monkey YWHAZ Protein, His-tagged Mammalian Cell His
Rhesus Macaque YWHAZ-5062R Recombinant Rhesus Macaque YWHAZ Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque YWHAZ-5062R-B Recombinant Rhesus Macaque YWHAZ Protein Pre-coupled Magnetic Beads HEK293
Zebrafish YWHAZ-12027Z Recombinant Zebrafish YWHAZ Mammalian Cell His
Chicken YWHAZ-2997C Recombinant Chicken YWHAZ Mammalian Cell His
  • Background
  • Quality Guarantee
  • Case Study
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

What is YWHAZ protein?

YWHAZ (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta) gene is a protein coding gene which situated on the long arm of chromosome 8 at locus 8q22. This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. The YWHAZ protein is consisted of 245 amino acids and its molecular mass is approximately 27.7 kDa.

What is the function of YWHAZ protein?

YWHAZ also known as 14-3-3ζ, acts as an adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. It binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif, leading to the modulation of the activity of the binding partner. It also promotes cytosolic retention and inactivation of TFEB transcription factor by binding to phosphorylated TFEB.

YWHAZ Related Signaling Pathway

YWHAZ protein is a highly conserved serine/threonine kinase protein binding chaperone involved in the regulation of several signaling pathways, including PI3K/Akt, MAPK/ERK, Wnt/β-catenin, JNK, etc. In the PI3K/Akt signaling pathway, YWHAZ interacts with Akt protein to promote the activation and stabilization of Akt, thus participating in the regulation of cell proliferation, survival and cell cycle.


Fig1. 14-3-3σ may generate an increase in cell proliferation, an increase in the proportion of cells in S phase, and a contribution to the chemoresistance of CCA toward gemcitabine. (Qiao Wu, 2020)

YWHAZ Related Diseases

YWHAZ protein has been implicated in the occurrence and development of many diseases, including cancer, neurological diseases, and cardiovascular diseases. Several studies have found that YWHAZ is abnormally expressed in various types of cancer and is associated with tumor proliferation, invasion, and metastasis. In addition, YWHAZ is also involved in the development and functional regulation of nerve cells, playing an important role in neurological diseases like autism, schizophrenia and so on. In addition, YWHAZ has been associated with diseases of the cardiovascular system, such as atherosclerosis and myocardial infarction.

Bioapplications of YWHAZ

The application of YWHAZ protein in the field of biology is mainly focused on the study of disease mechanisms, especially in the fields of oncology, neurobiology and developmental biology.

Case Study 1: Siqi Yin, 2022


Fig1. Western blot experiments verified the knockdown efficiency of 14-3-3ζ.

Case Study 2: Yingjie Qing, 2021


Fig2. The 14-3-3ζ promotes NSCLC cell mobility, migration and invasion.


Fig2. Overall model depicts that the absence of 14-3-3ζ results in severe inflammation and bone damage; mainly, increased IL-1β and reduced collagen levels are observed in the naïve and IA-affected animals. (Joshua Kim, 2021)

YWHAZ involved in several pathways and played different roles in them. We selected most pathways YWHAZ participated on our site, such as Cell cycle, Oocyte meiosis, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with YWHAZ were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
PIK-Akt signaling pathwayBAD;Il6ra;IL2RA;ITGB6;FGF16;TRP53;TCL1B;ITGA7;THBS3
Hippo signaling pathwayFBXW11;PPP2CB;RASSF1;BMP7;PPP2R2A;WNT3A;ACTB;TEAD4;WNT7A
Pathogenic Escherichia coli infectionTUBAL3;TUBB2B;NCK1;CTTN;ROCK2;TUBB7P;TUBA1B;TUBA3C;ACTB
Epstein-Barr virus infectionIKBKB;CCNA1;MAP3K7;MAP2K6;POLR3G;HDAC1;ICAM1;RB1;PSMC1

YWHAZ has several biochemical functions, for example, identical protein binding, poly(A) RNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by YWHAZ itself. We selected most functions YWHAZ had, and list some proteins which have the same functions with YWHAZ. You can find most of the proteins on our site.

Function Related Protein
identical protein bindingUSP2;CSK;BCAT1;AGER;VEGFA;ALK;ATL2;HSPB1;TMEM115
protein bindingEIF5;PLA2G16;VPS24;PSMB5;RUNX3;SLC26A6;USO1;TLN1;LAMTOR1
protein domain specific bindingPRKCI;CNTLN;CHMP2B;VCP;ARFIP1;VPS4A;TUBB;LAMP1;ARL1
protein kinase bindingCAMK2N2;FBXW5;PTPN23;KIF14;CDC42;CRY1;RPTOR;FAM83D;KIF20A
transcription factor bindingCSNK2B;HMGA1-RS1;SIRT2;KDM1A;ARRB1;DIP2BA;APBB1;UBE2I;SOX17
ubiquitin protein ligase bindingPOU5F1;PML;MFN2;RFFL;DNAJA1;POLR2A;CLU;CUL3A;CUL5A

YWHAZ has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with YWHAZ here. Most of them are supplied by our site. Hope this information will be useful for your research of YWHAZ.


Research Area

Related articles

van Rijn, SJ; Riemers, FM; et al. Expression Stability of Reference Genes for Quantitative RT-PCR of Healthy and Diseased Pituitary Tissue Samples Varies Between Humans, Mice, and Dogs. MOLECULAR NEUROBIOLOGY 49:893-899(2014).
Weber, R; Bertoni, APS; et al. Validation of Reference Genes for Normalization Gene Expression in Reverse Transcription Quantitative PCR in Human Normal Thyroid and Goiter Tissue. BIOMED RESEARCH INTERNATIONAL :-(2014).
  • Q&As
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Q&As (5)

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How does YWHAZ contribute to cardiovascular diseases? 09/03/2021

YWHAZ is involved in cardiovascular diseases by influencing processes like vascular smooth muscle cell proliferation and apoptosis.

Are there diagnostic applications of YWHAZ in cancer detection? 04/11/2021

Yes, elevated levels of YWHAZ protein have been detected in certain cancers, making it a potential biomarker for cancer diagnosis.

Is YWHAZ a potential biomarker for cardiovascular diseases? 01/27/2018

Preliminary studies suggest that YWHAZ levels may be altered in cardiovascular diseases, making it a candidate biomarker for further investigation.

Can YWHAZ protein be targeted for cancer treatment? 03/27/2016

Research suggests that targeting YWHAZ protein may be a viable strategy for developing anticancer therapies.

Are there potential therapeutic interventions targeting YWHAZ in neurodegenerative disorders? 03/18/2016

Investigational studies are exploring the modulation of YWHAZ as a potential therapeutic approach for neurodegenerative disorders.

Customer Reviews (3)

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      The YWHAZ Protein offers a wide range of applications, making it highly versatile for various experimental settings.


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