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Receptor Tyrosine Kinases (RTKs) in the Akt Pathway Proteins

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Receptor Tyrosine Kinases (RTKs) in the Akt Pathway Proteins

Creative BioMart Receptor Tyrosine Kinases (RTKs) in the Akt Pathway Proteins Product List
Receptor Tyrosine Kinases (RTKs) in the Akt Pathway Proteins Background

There are many types of Receptor Tyrosine Kinases involved in the Akt pathway, such as PPP2CB. Signal path diagram of PPP2CB in PI3K-AKT signaling pathway was shown in Figure 1. PPP2CB is an enzyme encoded by the PPP2CB gene in humans. This gene encodes a phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases and it is involved in a negative control of cell growth and division. It consists of a common heteromeric core enzyme consisting of a catalytic subunit and a constant regulatory subunit that binds to a variety of regulatory subunits. This gene encodes the beta isoform of the catalytic subunit. Two transcript variants encoding this gene have been identified that encode the same protein.

Figue1. PPP2CB protein in PI3K-AKT signaling pathway.

PPP2CB has been shown to interact with TLX1, PPP2R1B and PPP2R1A.

TLX1 Protein

T cell leukemia homeobox protein 1 (TLX1) is a protein encoded by the TLX1 gene in humans and was originally named HOX11.

PPP2R1B Protein

The PPP2R1B protein is an enzyme encoded by the PPP2R1B gene in humans. This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases and it is involved in negative controls for cell growth and division. It consists of a common heteromeric core enzyme consisting of a catalytic subunit and a constant regulatory subunit that binds to a variety of regulatory subunits. The constant regulatory subunit A is used as a scaffold molecule to coordinate the assembly of the catalytic subunit and the variable regulatory B subunit. This gene encodes a beta isoform of the constant regulatory subunit A. Defects in this gene may be the cause of certain lung and colon cancers. At least two transcript variants encoding different isoforms have been found for use in this gene.

PPP2R1A Protein

The PPP2R1A protein is an enzyme encoded by the PPP2R1A gene in humans. This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases and it is involved in negative controls for cell growth and division. It consists of a common heteromeric core enzyme consisting of a catalytic subunit and a constant regulatory subunit that binds to a variety of regulatory subunits. The constant regulatory subunit A is used as a scaffold molecule to coordinate the assembly of the catalytic subunit and the variable regulatory B subunit. This gene encodes the alpha isoform of the constant regulatory subunit A.

References:

1. Haynes JG.; et al. Molecular characterization of the B' regulatory subunit gene family of Arabidopsis protein phosphatase 2A. Eur. J. Biochem,1999,260(1):127-136

2. Hemmings BA.; et al. Alpha- and beta-forms of the 65-kDa subunit of protein phosphatase 2A have a similar 39 amino acid repeating structure. Biochemistry. 1990, 29 (13): 3166-3173.

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