alox5

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alox5

Official Full Name arachidonate 5-lipoxygenase
Background This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined.
Synonyms ALOX5; arachidonate 5-lipoxygenase; 5 LOX; leukotriene A4 synthase; arachidonic acid 5-lipoxygenase; arachidonic 5-lipoxygenase alpha-10 isoform; arachidonic 5-lipoxygenase delta-13 isoform; arachidonic 5-lipoxygenase delta-p10 isoform; arachidonic 5-lipo
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • E.Coli or Yeast
    • HEK293
    • Mammalian Cell
    • S.frugiperda
    • Sf21 Insect Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ALOX5-26026TH Recombinant Human ALOX5 Wheat Germ N/A
    Human ALOX5-487H Recombinant Human ALOX5 Protein, GST-tagged Wheat Germ GST
    Human ALOX5-578H Recombinant Human Arachidonate 5-lipoxygenase 1 Sf21 Insect Cell N/A
    Human ALOX5-6847H Recombinant Human ALOX5 protein, His-tagged E.coli His
    Human ALOX5-696H Recombinant Human Arachidonate 5-lipoxygenase Sf21 Insect Cell N/A
    Human ALOX5-723H Recombinant Human Arachidonate 5-lipoxygenase 1 S.frugiperda N/A
    Human ALOX5-8896HCL Recombinant Human ALOX5 293 Cell Lysate HEK293 N/A
    Mouse ALOX5-1567M Recombinant Mouse ALOX5 Protein Mammalian Cell His
    Mouse Alox5-6848M Recombinant Mouse Alox5 protein, His-tagged E.coli His
    Rat Alox5-3610R Recombinant Rat Alox5, His-tagged E.Coli or Yeast His
    Rat ALOX5-638R Recombinant Rat ALOX5 Protein Mammalian Cell His

    alox5 involved in several pathways and played different roles in them. We selected most pathways alox5 participated on our site, such as Arachidonic acid metabolism, Metabolic pathways, Serotonergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with alox5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Arachidonic acid metabolism CYP2Y3; ALOX8; FAM213B; CYP2B19; PTGS2A; PLA2G4F; CYP4A10; AKR1C6; ALOX5B.3; PTGDSA
    Metabolic pathways GMPPB; SC4MOL; FAHD1; GALT; PLCD1A; GKUP; PRODH2; SPTLC1; PTGES3A; NME1-NME2
    Serotonergic synapse HTR3A; HTR3E; CYP2J6; HTR5A; HTR1E; GNAQ; PRKCG; CYP2D9; CYP4X1; HTR4
    Ovarian steroidogenesis HSD3B6; Adcy4; LDLR; PTGS2; ALOX5; PRKACG; SCARB1; FSHR; INS; HSD17B7
    Toxoplasmosis TNF; PIK3R5; MAPK3; BCL2L1; LAMB2; PIK3CD; ALOX5; Toxoplasma Gondii Microneme Protein MIC3; TAB2; GNAO1

    alox5 has several biochemical functions, for example, arachidonate 5-lipoxygenase activity, iron ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by alox5 itself. We selected most functions alox5 had, and list some proteins which have the same functions with alox5. You can find most of the proteins on our site.

    Function Related Protein
    arachidonate 5-lipoxygenase activity ALOX5
    iron ion binding P4HA1; KDM3A; POR; CYP27C1; CYP20A1; CYP2K19; CYP1A4; TPH2; HBB-BH1; OGFOD1
    protein binding PPP2R5E; POGK; C17orf59; RECQL; BTBD1; NME1; RAD51; POLR2E; USF2; CSDC2

    alox5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with alox5 here. Most of them are supplied by our site. Hope this information will be useful for your research of alox5.

    COTL1; MEOX1; REL; HHIPL2; NUTM1; CEP57L1; SYCE1

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