What is TSHB Protein?

Thyroid Stimulating Hormone Beta (TSHB) is a critical protein in the human body that plays a pivotal role in regulating several metabolic activities.

The discovery of the TSHB protein can be traced back to the earlier phases of genetic research. The understanding of this protein has grown exponentially with recent scientific advancements, giving us deeper insights into its genetic background, structure, and its pivotal role in body functioning. The TSHB protein is encoded by the TSHB gene, which is situated on chromosome 1 in humans at the specific locus 1p13.2. It contains two exons separated by a small intron.

What Is The Structure of TSHB Protein?

Concerning its protein structure, TSHB, along with another protein called TSHA, forms a heterodimer, which is also known as the Thyroid Stimulating Hormone (TSH). The TSHB subunit contributes to the hormone-specific beta portion of this heterodimer, while TSHA forms the alpha portion, which is common to other pituitary hormones such as Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH).

(from GeneCards)

What Is The Function of TSHB Protein?

Functionally, TSHB primarily contributes to regulating the body's metabolic processes. TSH, the hormone constituted partially by TSHB, is secreted by the pituitary gland and is fundamental in controlling the production and release of the thyroid hormones triiodothyronine (T3) and thyroxine (T4) from the thyroid gland. T3 and T4 are directly responsible for managing several crucial bodily functions such as temperature regulation, energy production, and metabolism.

TSHB protein related signal pathway

In terms of signal transmission pathways, TSHB plays a significant role. The secretion of TSH from the pituitary gland influences the thyroid gland's function. The rise and fall in the level of thyroid hormones in the blood regulate TSH's secretion via a negative feedback loop. The hypothalamus and pituitary gland sense a low level of thyroid hormones, which signals the pituitary gland to increase TSH secretion, thus increasing thyroid hormone production. Conversely, when the levels of thyroid hormones are high, TSH secretion decreases.

TSHB protein related diseases

As critical as TSHB protein is to physiological functions, it is central to certain diseases, mostly linked to thyroid function. These include hyperthyroidism, hypothyroidism, and thyroid cancer. Hyperthyroidism, marked by overactive thyroid gland and overproduction of thyroid hormones, often results from excessive stimulation by TSH. Conversely, hypothyroidism, characterized by an underactive thyroid gland and underproduction of thyroid hormones, can result from insufficient TSH secretion. Thyroid cancer, one of the most common endocrine malignancies, has also been linked with abnormal TSH levels, suggesting an association with the TSHB protein.

TSHB protein's applications in biomedical

The potential applications of TSHB protein in biomedicine are equally significant. Identification of aberrant TSH levels became a diagnostic tool in both hyperthyroidism and hypothyroidism. Additionally, in cases of thyroid cancer, measuring TSH levels serves as an active monitoring method after thyroidectomy. In drug development, understanding TSHB protein's physiological role can provide essential insights into creating therapeutics targeting metabolic disorders and thyroid diseases.

In conclusion, the TSHB protein is not just another protein encoded by our vast genome; rather, it underscores our body's intricate complexity with its critical function in regulating our metabolic rate and energy production. Its association with several thyroid-related diseases marks its significance in clinical practice, while its potential applications in biomedicine continue to open promising avenues. The ongoing research in this field is an attempt at decoding our biological systems, enhancing our understanding of diseases, and continually improving the quality of health care.

Our Featured Products

Cat.No.	Product Name	Species	Source (Host)	Tag
TSHB-105H	Active Recombinant Human TSHB protein	Human	CHO	N/A
TSHB-2427H	Recombinant human TSHB, His-tagged	Human	E.coli	His
TSHB-185H	Recombinant Human TSHB protein, MYC/DDK-tagged	Human	HEK293	Myc/DDK
TSHB-3626H	Recombinant Human TSHB protein, His-SUMO-tagged	Human	E.coli	His-SUMO
Tshb-7935M	Recombinant Mouse Tshb protein, His-tagged	Mouse	E.coli	His
Tshb-6684M	Recombinant Mouse Tshb Protein, Myc/DDK-tagged	Mouse	HEK293T	Myc/DDK
TSHB-5973R	Recombinant Rat TSHB Protein, His (Fc)-Avi-tagged	Rat	HEK293	His (Fc)-Avi