ABCA7 Protein, ATP-binding cassette, sub-family A (ABC1), member 7


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Official Full Name ATP-binding cassette, sub-family A (ABC1), member 7
Background The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This protein is widely expressed with highest detection in spleen and hematopoietic tissues. The function of this protein has not yet been determined; however, a related human protein is thought to play a role in lipid homeostasis in cells of the immune system.
Synonyms ABCA7; ATP-binding cassette, sub-family A (ABC1), member 7; ATP-binding cassette sub-family A member 7; ABC transporter ABCA7; ABC transporter member 7; ABCA SSN; ABCX; ATP binding cassette sub family A (ABC1) member 7; ATP binding cassette sub family A member 7; ATP binding Cassette Transporter A7; FLJ40025; Macrophage ABC transporter; OTTMUSP00000043312; Abc51
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • Mammalian Cell
    • Tag :
    • His
    • GST
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ABCA7-1677H Recombinant Human ABCA7 protein, His & GST-tagged E.coli His/GST
    Human ABCA7-753H Recombinant Human ABCA7 Mammalian Cell His
    Mouse ABCA7-1083M Recombinant Mouse ABCA7 Protein Mammalian Cell His
    Rat ABCA7-395R Recombinant Rat ABCA7 Protein Mammalian Cell His

    ABCA7 involved in several pathways and played different roles in them. We selected most pathways ABCA7 participated on our site, such as ABC transporters, ABC transporters in lipid homeostasis, ABC-family proteins mediated transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with ABCA7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    ABC transporters ABCA6; SUR2A; ABCB1LB; ABCB1A; ABCB7; ABCD1; ABCC8; ABCA3; ABCC11; ABCC3
    ABC transporters in lipid homeostasis APOA1B; ABCD3B; ABCG4B; ABCA7
    ABC-family proteins mediated transport ABCA4A; APOA1B; ABCA8; ABCC9; EIF2S3; ABCB8; ABCE1; ABCG4B; ABCA7; ABCD3B
    Transmembrane transport of small molecules LCN2; ATP2C2; ATP13A5; BSND; ADD3A; SLC35A2; MYO5B; SLCO3A1; TTYH3B; SLC7A8A

    ABCA7 has several biochemical functions, for example, ATP binding, contributes_to ATPase activity, ATPase activity, coupled to transmembrane movement of substances. Some of the functions are cooperated with other proteins, some of the functions could acted by ABCA7 itself. We selected most functions ABCA7 had, and list some proteins which have the same functions with ABCA7. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding LRRK2; TSSK1; ENTPD2; TAP1; PSKH2; ULK4; SGK2; FGFR1A; SLK; DDX6
    contributes_to ATPase activity PPP2R4; ATP5I; ATP5C1; ABCG8; ATP5F1; ATP1A2; RUVBL2; ATP5H; ATP5J; ATP5O
    ATPase activity, coupled to transmembrane movement of substances ABCA3; ABCB7; ABCB4; ABCB8; ABCA8; ABCC3; ABCG2A; SFRP5; ABCC2; DPY19L2
    apolipoprotein A-I receptor activity ABCA7; ABCA1
    cholesterol transporter activity APOEB; ABCA1B; ABCA13; APOE; ABCG4B; APOA4A; APOA5; APOA1A; ABCA7; ABCA1
    phospholipid transporter activity APOA1; ABCA4; ABCA1; ABCA7; MFSD2AB; ABCA13; ABCA4A; ABCA1B; MFSD2AA; ATP8B5
    transporter activity ATP5D; UCP3; NUP155; AP3B2; SYPA; SCARB1; HIAT1B; AQP12B; SLC13A1; AP4M1

    ABCA7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ABCA7 here. Most of them are supplied by our site. Hope this information will be useful for your research of ABCA7.

    Morales, CR; Ni, XY; et al. ABCA17 mediates sterol efflux from mouse spermatozoa plasma membranes. HISTOLOGY AND HISTOPATHOLOGY 27:317-328(2012).
    Morales, CR; Marat, AL; et al. ATP-binding cassette transporters ABCA1, ABCA7, and ABCG1 in mouse spermatozoa. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 376:472-477(2008).

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