ACSL4
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Official Full Name
acyl-CoA synthetase long-chain family member 4
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Overview
The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme preferentially utilizes arachidonate as substrate. The absence of this enzyme may contribute to the mental retardation or Alport syndrome. Alternative splicing of this gene generates 2 transcript variants. -
Synonyms
ACSL4; acyl-CoA synthetase long-chain family member 4; FACL4, fatty acid Coenzyme A ligase, long chain 4 , mental retardation, X linked 63 , mental retardation, X linked 68 , MRX63, MRX68; long-chain-fatty-acid--CoA ligase 4; long chain fatty acid Coen;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Homo sapiens (Human)
- Human
- Mouse
- Rat
- Rhesus Macaque
- E.coli
- E.coli expression system
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mamanlian cells
- Mammalian Cell
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- ACSL4 Related Articles
ACSL4 involved in several pathways and played different roles in them. We selected most pathways ACSL4 participated on our site, such as Fatty acid biosynthesis, Fatty acid degradation, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACSL4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Fatty acid biosynthesis | MCAT;OXSM;ACSL1A;ACSL4;ECH1;OLAH;ECHDC2;ACSBG1;ACACA |
| Fatty acid degradation | ADH2-1;ACSL5;ACADM;ACSL1B;CPT1A;ACSL3;CYP4A12A;ACSL4A;ACADL |
| Metabolic pathways | TM7SF2;CDIPT;CHKB;CHPT1;INPP5K;CDO1;AKR1B7;SPTLC2A;SMPD5 |
| Fatty acid metabolism | ACSL3A;HADHAA;HSD17B12B;ACAA2;FADS1;CPT2;ACADS;CPT1B;SCD5 |
| PPAR signaling pathway | RXRGA;APOC3;MMP1;ACADM;ADIPOQB;PDPK1;CD36;CYP4A14;ACAA1A |
| Peroxisome | PEX14;BAAT;ACAA1A;PEX7;PEX10;MPV17L2;ECH1;PECR;PEX2 |
| Adipocytokine signaling pathway | ACSL1;ACSL5;G6PC3;PRKAB1B;ACSL4A;AKT2L;CAMKK1A;LEPB;MAPK8B |
ACSL4 has several biochemical functions, for example, ATP binding, arachidonate-CoA ligase activity, long-chain fatty acid-CoA ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ACSL4 itself. We selected most functions ACSL4 had, and list some proteins which have the same functions with ACSL4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | SYN1;DQX1;PIK3R4;PFTK1;ANKK1;HSPA4;PRKAG3;CCT6A;VPRBP |
| arachidonate-CoA ligase activity | |
| long-chain fatty acid-CoA ligase activity | ACSL1;SLC27A1A;SLC27A5;ACSL3;SLC27A3;ACSBG2;SLC27A4;ACSL4;ACSL5 |
| very long-chain fatty acid-CoA ligase activity | SLC27A4;ACSBG1;ACSL4;SLC27A1A;SLC27A2;SLC27A3;SLC27A1B;SLC27A5 |
ACSL4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACSL4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACSL4.
YWHAZ; DSE; 1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate; ACSL3; 1C; ABCG1; MRPS15; SLC1A5; TJAP1; SPG20; EDEM1; BRF1; UVRAG; p27958-pro_0000037575; TMEM173
- Q&As
- Reviews
Q&As (10)
Ask a questionACSL4 has been shown to impact gene expression by regulating the availability of long-chain fatty acids for the production of signaling molecules that can impact gene expression.
ACSL4 mutations have been linked to a variety of human diseases, including metabolic disorders, neurodegenerative diseases, and cancer.
ACSL4 dysregulation has been linked to the development of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, as it can contribute to alterations in lipid metabolism and oxidative stress.
ACSL4 has been shown to impact oxidative stress, a condition characterized by an imbalance between the production of reactive oxygen species and antioxidant defenses, by regulating the availability of long-chain fatty acids for the production of antioxidant molecules.
ACSL4 has been shown to impact mitochondrial function by regulating the availability of long-chain fatty acids for energy production and cellular signaling pathways.
ACSL4 dysregulation has been implicated in the development of cancer, as it can promote tumor cell survival and growth by altering lipid metabolism and signaling pathways.
ACSL4 has been shown to play a role in inflammation by regulating the availability of long-chain fatty acids for the production of inflammatory mediators, such as prostaglandins and leukotrienes.
ACSL4 dysregulation has been linked to the development of insulin resistance, a condition characterized by impaired glucose uptake and utilization, which can contribute to the development of metabolic disorders, such as obesity and diabetes.
ACSL4 expression is regulated by a variety of mechanisms, including transcriptional regulation, post-transcriptional regulation, and post-translational modifications.
The ACSL4 gene is expressed in a variety of tissues, including adipose tissue, liver, muscle, heart, and brain.
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