|Official Full Name||acyl-CoA synthetase long-chain family member 4|
|Background||The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme preferentially utilizes arachidonate as substrate. The absence of this enzyme may contribute to the mental retardation or Alport syndrome. Alternative splicing of this gene generates 2 transcript variants.|
|Synonyms||ACSL4; acyl-CoA synthetase long-chain family member 4; FACL4, fatty acid Coenzyme A ligase, long chain 4 , mental retardation, X linked 63 , mental retardation, X linked 68 , MRX63, MRX68; long-chain-fatty-acid--CoA ligase 4; long chain fatty acid Coen|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
ACSL4 involved in several pathways and played different roles in them. We selected most pathways ACSL4 participated on our site, such as Fatty acid biosynthesis, Fatty acid degradation, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACSL4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Fatty acid biosynthesis||ACSBG1; ACSL3; FASN; ACAA2; ACSL4; ACACB; OLAH; ECH1; ACSL3A; ACSL4B|
|Fatty acid degradation||ACSL1B; ACADS; ACSL5; EHHADH; ACSBG2; ACAT1; CYP4A10; ADH4; ECI1; ACAA2|
|Metabolic pathways||GAPDHS; GRHPRB; GLS; SDHB; THTPA; ALOX12; NDUFB5; ATP5F1; PDXK; PFKMB|
|Fatty acid metabolism||MCAT; ACSBG1; EHHADH; HADHB; ACSL3A; Scd1; HSD17B12A; ACSL1A; HADHA; PECR|
|PPAR signaling pathway||SLC27A1A; UCP1; PLTP; ACSL3; ACSL3B; FABP7; APOC3; Scd2; PLIN1; FABP1|
|Peroxisome||DAO.3; NUDT19; IDH1; PEX12; PEX5; ABCD2; ABCD3; ACAA1; HMGCLL1; ACSL3B|
|Adipocytokine signaling pathway||PRKAG3; PRKAA1; TNF; NFKBIA; IRS4; TNFRSF1B; PRKAG3B; PRKAG1; STAT3; CPT1A|
ACSL4 has several biochemical functions, for example, ATP binding, arachidonate-CoA ligase activity, long-chain fatty acid-CoA ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ACSL4 itself. We selected most functions ACSL4 had, and list some proteins which have the same functions with ACSL4. You can find most of the proteins on our site.
|ATP binding||DGUOK; ADCY3; MAP2K2B; MOK; OLA1; KCNJ1; EPHA4A; ATP1A1; LRRK1; RBM4.3|
|arachidonate-CoA ligase activity||ACSL4|
|long-chain fatty acid-CoA ligase activity||SLC27A5; ACSL4; ACSL3; ACSBG1; SLC27A1B; SLC27A1A; SLC27A4; ACSBG2; ACSL1; SLC27A3|
|very long-chain fatty acid-CoA ligase activity||SLC27A2; SLC27A4; ACSBG1; SLC27A3; ACSL4; SLC27A5; SLC27A1A; SLC27A1B|
ACSL4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACSL4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACSL4.
YWHAZ; DSE; 1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate; ACSL3; 1C; ABCG1; MRPS15; SLC1A5; TJAP1; SPG20; EDEM1; BRF1; UVRAG; p27958-pro_0000037575; TMEM173