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Official Full Name acyl-CoA synthetase long-chain family member 4
Background The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme preferentially utilizes arachidonate as substrate. The absence of this enzyme may contribute to the mental retardation or Alport syndrome. Alternative splicing of this gene generates 2 transcript variants.
Synonyms ACSL4; acyl-CoA synthetase long-chain family member 4; FACL4, fatty acid Coenzyme A ligase, long chain 4 , mental retardation, X linked 63 , mental retardation, X linked 68 , MRX63, MRX68; long-chain-fatty-acid--CoA ligase 4; long chain fatty acid Coen
    • Species :
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Acsl4-1507M Recombinant Mouse Acsl4 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human ACSL4-5997H Recombinant Human ACSL4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human ACSL4-198H Recombinant Human ACSL4 Protein, GST-tagged Wheat Germ GST
    Human ACSL4-199H Recombinant Human ACSL4 Protein, GST-tagged Wheat Germ GST
    Human ACSL4-9074H Recombinant Human ACSL4 protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human ACSL4-9074HCL Recombinant Human ACSL4 293 Cell Lysate HEK293 N/A
    Human ACSL4-9075HCL Recombinant Human ACSL4 293 Cell Lysate HEK293 N/A
    Rat ACSL4-471R Recombinant Rat ACSL4 Protein Mammalian Cell His
    Rhesus Macaque ACSL4-218R Recombinant Rhesus monkey ACSL4 Protein, His-tagged Mammalian Cell His

    ACSL4 involved in several pathways and played different roles in them. We selected most pathways ACSL4 participated on our site, such as Fatty acid biosynthesis, Fatty acid degradation, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACSL4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Fatty acid biosynthesis ACSBG1; ACSL3; FASN; ACAA2; ACSL4; ACACB; OLAH; ECH1; ACSL3A; ACSL4B
    Fatty acid degradation ACSL1B; ACADS; ACSL5; EHHADH; ACSBG2; ACAT1; CYP4A10; ADH4; ECI1; ACAA2
    Fatty acid metabolism MCAT; ACSBG1; EHHADH; HADHB; ACSL3A; Scd1; HSD17B12A; ACSL1A; HADHA; PECR
    PPAR signaling pathway SLC27A1A; UCP1; PLTP; ACSL3; ACSL3B; FABP7; APOC3; Scd2; PLIN1; FABP1
    Peroxisome DAO.3; NUDT19; IDH1; PEX12; PEX5; ABCD2; ABCD3; ACAA1; HMGCLL1; ACSL3B
    Adipocytokine signaling pathway PRKAG3; PRKAA1; TNF; NFKBIA; IRS4; TNFRSF1B; PRKAG3B; PRKAG1; STAT3; CPT1A

    ACSL4 has several biochemical functions, for example, ATP binding, arachidonate-CoA ligase activity, long-chain fatty acid-CoA ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ACSL4 itself. We selected most functions ACSL4 had, and list some proteins which have the same functions with ACSL4. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding DGUOK; ADCY3; MAP2K2B; MOK; OLA1; KCNJ1; EPHA4A; ATP1A1; LRRK1; RBM4.3
    arachidonate-CoA ligase activity ACSL4
    long-chain fatty acid-CoA ligase activity SLC27A5; ACSL4; ACSL3; ACSBG1; SLC27A1B; SLC27A1A; SLC27A4; ACSBG2; ACSL1; SLC27A3
    very long-chain fatty acid-CoA ligase activity SLC27A2; SLC27A4; ACSBG1; SLC27A3; ACSL4; SLC27A5; SLC27A1A; SLC27A1B

    ACSL4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACSL4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACSL4.

    YWHAZ; DSE; 1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate; ACSL3; 1C; ABCG1; MRPS15; SLC1A5; TJAP1; SPG20; EDEM1; BRF1; UVRAG; p27958-pro_0000037575; TMEM173

    Tuohetahuntila, M; Spee, B; et al. Role of long-chain acyl-CoA synthetase 4 in formation of polyunsaturated lipid species in hepatic stellate cells. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS 1851:220-230(2015).
    Xu, WD; Yang, XY; et al. Up-regulation of fatty acid oxidation in the ligament as a contributing factor of ankylosing spondylitis: A comparative proteomic study. JOURNAL OF PROTEOMICS 113:57-72(2015).

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