ADCY5
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Official Full Name
adenylate cyclase 5
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Overview
This gene encodes a member of the membrane-bound adenylyl cyclase enzymes. Adenylyl cyclases mediate G protein-coupled receptor signaling through the synthesis of the second messenger cAMP. Activity of the encoded protein is stimulated by the Gs alpha subunit of G protein-coupled receptors and is inhibited by protein kinase A, calcium and Gi alpha subunits. Single nucleotide polymorphisms in this gene may be associated with low birth weight and type 2 diabetes. Alternatively spliced transcript variants that encode different isoforms have been observed for this gene. -
Synonyms
ADCY5; adenylate cyclase 5; adenylate cyclase type 5; AC5; AC 5; ADCY 5; Adenylate cyclase type V; Adenylyl cyclase 5; ATP pyrophosphate lyase 5; OTTHUMP00000215640; OTTHUMP00000215641; OTTHUMP00000215642; OTTHUMP00000215643; ATP pyrophosphate-lyase 5;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rabbit
- Rat
- Zebrafish
- E.coli
- E.Coli or Yeast
- HEK293
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- His|T7
- N
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | ADCY5-6927H | Recombinant Human ADCY5 protein, His & T7-tagged | E.coli | His/T7 | Gly167~Glu385 (Accession # O95622) | |
Human | ADCY5-329H | Recombinant Human ADCY5 Protein, GST-tagged | Wheat Germ | GST | ||
Human | ADCY5-0374H | Recombinant Human ADCY5 Protein (Gly167-Ile385), N-His-tagged | E.coli | N-His | Gly167-Ile385 | |
Mouse | Adcy5-3177M | Recombinant Mouse Adcy5, GST-tagged | E.Coli or Yeast | GST | 1262 | |
Rat | ADCY5-518R | Recombinant Rat ADCY5 Protein | Mammalian Cell | His | ||
Rat | ADCY5-174R-B | Recombinant Rat ADCY5 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Rat | ADCY5-174R | Recombinant Rat ADCY5 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Rabbit | ADCY5-3176R | Recombinant Rabbit ADCY5, GST-tagged | E.Coli or Yeast | GST | 1264 | |
Zebrafish | ADCY5-7665Z | Recombinant Zebrafish ADCY5 | Mammalian Cell | His | ||
Chicken | ADCY5-6199C | Recombinant Chicken ADCY5 | Mammalian Cell | His |
- Q&As
- Reviews
Q&As (15)
Ask a questionNo, Adcy5 protein is found in many different organisms, including mammals, birds, reptiles, fish, and even some invertebrates. It plays a conserved role in regulating cAMP levels within cells, suggesting that it has been evolutionarily conserved for its critical role in cellular signaling.
Yes, targeting Adcy5 is a potential strategy for treating some types of cancer. Overexpression of Adcy5 has been observed in several cancer types, including breast, prostate, and pancreatic cancer. Inhibiting Adcy5 activity may help to slow the growth and spread of cancer cells.
There are no drugs specifically designed to target Adcy5 for ADHD treatment, but stimulant medications like methylphenidate and amphetamines indirectly increase Adcy5 activity by promoting dopamine release. These drugs have been shown to improve ADHD symptoms in many patients.
Yes, mutations in Adcy5 have been associated with several different diseases, including Parkinson's disease, ADHD, and epilepsy. These mutations can disrupt the normal activity of the protein, leading to alterations in cellular signaling and function.
Adcy5 protein and its signaling pathway are potential targets for the development of novel drugs. Drug discovery efforts can aim to either directly or indirectly modulate Adcy5 activity or regulate its downstream signaling pathways. High-throughput screening, virtual screening, and molecular dynamics simulations can be used to identify potential drug candidates.
As with any drug, there is always the potential for side effects. However, because Adcy5 is expressed in many different tissues and involved in many different biological processes, any drug targeting Adcy5 would need to be designed specifically to minimize off-target effects.
Adcy5 is involved in a variety of diseases and conditions, including Parkinson's disease, attention deficit hyperactivity disorder (ADHD), epilepsy, type 2 diabetes, and various forms of cancer.
Yes, Adcy5 is essential for normal physiological function, as it plays a critical role in regulating cyclic AMP (cAMP) levels within cells. cAMP is a critical secondary messenger that is involved in numerous signaling pathways within the cell, including those involved in neurotransmission, metabolism, and hormone signaling.
Yes, Adcy5 protein has been implicated in the development and progression of Parkinson's disease. It is involved in dopamine signaling, which is disrupted in Parkinson's disease. Targeting Adcy5, either directly or indirectly, may improve dopamine signaling and alleviate some of the symptoms of Parkinson's disease.
There are currently no therapies that specifically target Adcy5, although several drugs that indirectly modulate its activity have been developed. These include dopamine agonists for Parkinson's disease and stimulant medications for ADHD, which both indirectly target Adcy5 activity via dopamine signaling.
Adcy5 has been linked to ADHD, although the specific mechanism is not yet fully understood. Studies suggest that genetic variations in Adcy5 may be associated with an increased risk of ADHD.
Adcy5 gene mutations have been associated with several diseases, including Parkinson's disease, ADHD, and epilepsy. Therefore, Adcy5 may be used as a biomarker for those diseases. However, more research is needed to determine the extent to which Adcy5 can be used as a reliable biomarker.
Adcy5 has been implicated in the development and progression of several types of cancer, including lung cancer, liver cancer, and prostate cancer. It is involved in the regulation of cell growth, proliferation, and survival. Targeting Adcy5 and its downstream pathways may provide new opportunities for cancer therapy and improve patient outcomes.
Yes, Adcy5 is a potential target for drug development in Parkinson's disease. Inhibition of Adcy5 has been shown to reduce the aggregation of alpha-synuclein, which is a hallmark of Parkinson's disease.
Yes, Adcy5 plays an important role in neuronal signaling by regulating the production of cyclic AMP (cAMP). cAMP is an important secondary messenger that is involved in many different signaling pathways within the cell, including those involved in neurotransmission.
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