ADH6

  • Official Full Name

    alcohol dehydrogenase 6 (class V)

  • Overview

    This gene encodes class V alcohol dehydrogenase, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. This gene is expressed in the stomach as well as in the liver, and it contains a glucocorticoid response element upstream of its 5 UTR, which is a steroid hormone receptor binding site. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

  • Synonyms

    ADH6;alcohol dehydrogenase 6 (class V);alcohol dehydrogenase 6;ADH 5;ADH 6;Aldehyde reductase;Class V alcohol dehydrogenase 6;UDP GLUCURONOSYLTRANSFERASE 2B10 PRECURSOR, MICROSOMAL;OTTHUMP00000161647;OTTHUMP00000161648;OTTHUMP00000161649;OTTHUMP00000220107;ADH-5

Recombinant Proteins

  • Human
  • Rat
  • Chicken
  • E.coli
  • Wheat Germ
  • Mammalian Cells
  • HEK293
  • In Vitro Cell Free System
  • His
  • GST
  • Non
  • DDK
  • Myc
  • Avi
  • Fc

    Involved Pathway

    ADH6 involved in several pathways and played different roles in them. We selected most pathways ADH6 participated on our site, such as Biological oxidations,Chemical carcinogenesis,Drug metabolism - cytochrome P450, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADH6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Ethanol oxidation ADH1A,ADH1B,ADH5,ADH8B,ADH7,ADH8A,ADH4,ADH1C
    Fatty acid degradation ALDH2,CYP4A11,ACSL1B,GCDH,CPT1C,ALDH2.1,ADH2-2,CPT1A,ADH2-1,ACSL1A
    Metabolic pathways MTHFR,ADH1,POLR2H,HOGA1,LTA4H,NDUFB6,ENO2,EARS2,ST6GAL2A,P4HA1
    Fatty Acid Omega Oxidation ADH1B,ADH1C,ADH7,ADH1A,CYP2A6,ADH4,CYP2D6,CYP4A11,CYP2E1,CYP1A1
    Biological oxidations Sult2a6,ADH1A,CYP2S1,POMCB,CYP2E1,SULT1ST6,ADH8B,SULT1C2,CYP2AD6,SLC26A2
    Drug metabolism - cytochrome P450 CYP2D6,ADH2-1,ADH1A,ADH2-2,ADH5,GSTO2,CYP2C19,ADH7,GSTK1,ADH1B
    Chemical carcinogenesis NAT1,GSTM7,UGT2B15,GSTK1,CBR1,CYP2C9,ALDH3B2,CYP3A7-CYP3AP1,GSTA4,SULT1A3
    Glycolysis / Gluconeogenesis ALDH1B1,LDHAL6B,ENO1A,PGM2,PCK1,LDHBB,BPGM,ADH1,TPI1B,G6PC

    Protein Function

    ADH6 has several biochemical functions, for example, alcohol dehydrogenase (NAD) activity,zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADH6 itself. We selected most functions ADH6 had, and list some proteins which have the same functions with ADH6. You can find most of the proteins on our site.

    Function Related Protein
    alcohol dehydrogenase (NAD) activity ADH1A,ADH1,ADH5,ADH4,ADH1C,DHRS9,ADH7,ADH8B,ADH8A
    zinc ion binding CAPNS2,TRIM52,ZFAND2B,ZFP326,CIZ1B,ADH1C,SAMHD1,PDLIM3,GTF2H2C_2,PHF23A

    Interacting Protein

    ADH6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADH6 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADH6.

    TNIP1;ANKRD17;RSL1D1;KRAS;ARRB1;RPS29;RPAIN;RASSF5

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