Recombinant Human ADH6 Protein, GST-tagged

• Cat.No.: ADH6-351H
• Product Overview: Human ADH6 full-length ORF ( AAH39065.1, 1 a.a. - 295 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes class V alcohol dehydrogenase, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. This gene is expressed in the stomach as well as in the liver, and it contains a glucocorticoid response element upstream of its 5' UTR, which is a steroid hormone receptor binding site. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 57.7 kDa
• AA Sequence: MSTTGQVIRCKAAILWKPGAPFSIE EVEVAPPKAKEVRIKVVATGLCGTE MKVLGSKHLDLLYPTILGHEGAGIV ESIGEGVSTVKPGDKVITLFLPQCG ECTSCLNSEGNFCIQFKQSKTQLMS DGTSRFTCKGKSIYHFGNTSTFCEY TVIKEISVAKIDAVAPLEKVCLISC GFSTGFGAAINTAKVTPGSTCAVFG LGGVGLSVVMGCKAAGAARIIGVDV NKEKFKKAQELGATECLNPQDLKKP IQEVLFDMTDAGIDFCFEAIGNLDV LAGRADSTSLNWLLIIWQRS
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: ADH6 alcohol dehydrogenase 6 (class V) [ Homo sapiens ]
• Official Symbol: ADH6
• Synonyms: ADH6; alcohol dehydrogenase 6 (class V); alcohol dehydrogenase 6; ADH 5; aldehyde reductase; ADH-5
• Gene ID: 130
• mRNA Refseq: NM_000672
• Protein Refseq: NP_000663
• MIM: 103735
• UniProt ID: P28332

Reviews

06/03/2021

Provides accurate and precise measurement of protein-ligand binding affinities in binding kinetics assays.

11/02/2018

Shows outstanding performance in protein-protein docking simulations.

Q&As

What is the impact of ADH6 deficiency or overexpression on alcohol metabolism and its physiological consequences?

Exploring the consequences of ADH6 deficiency or overexpression provides insights into its role in alcohol metabolism and its impact on physiological processes related to alcohol-related disorders.

What is the tissue-specific expression pattern of ADH6, and how does it compare to the expression patterns of other ADH isoforms?

ADH6 exhibits a tissue-specific expression pattern, which may differ from other ADH isoforms, highlighting its unique role in specific tissues.

Are there any specific interacting partners or cofactors that modulate the activity or function of ADH6, and what are the underlying molecular mechanisms?

ADH6 can interact with specific partners or cofactors that modulate its activity or function, and studying the underlying molecular mechanisms elucidates its regulatory mechanisms.

How does ADH6 expression and activity change in response to different alcohol concentrations or exposure durations, and what are the molecular mechanisms underlying these changes?

ADH6 expression and activity can change in response to varying alcohol concentrations or exposure durations, and understanding the molecular mechanisms involved enhances our knowledge of alcohol-related effects.

Can ADH6 activity be modulated by pharmacological agents or environmental factors, and are there potential therapeutic implications?

ADH6 activity may be modulated by pharmacological agents or environmental factors, suggesting potential therapeutic implications and the possibility of targeting ADH6 in treatment strategies.

What are the structural features of ADH6, and how do they relate to its catalytic activity and binding properties?

Investigating the structural features of ADH6 provides valuable information on its catalytic activity and binding properties, aiding in understanding its function.

Can ADH6 metabolize other endogenous compounds or xenobiotics besides alcohol, and if so, what are the implications for its broader physiological functions?

ADH6 may participate in the metabolism of other endogenous compounds or xenobiotics, suggesting its involvement in broader physiological functions beyond alcohol metabolism.

How is ADH6 expression regulated at the transcriptional and post-transcriptional levels, and are there any specific factors or signaling pathways involved?

ADH6 expression is regulated at the transcriptional and post-transcriptional levels by various factors and signaling pathways, providing insights into its regulation.

Are there any known genetic variations or polymorphisms in the ADH6 gene associated with altered alcohol metabolism or susceptibility to alcohol-related disorders?

Genetic variations or polymorphisms in the ADH6 gene may impact alcohol metabolism and susceptibility to alcohol-related disorders, emphasizing the role of genetic factors in its function.

What are the enzymatic kinetics and substrate specificity of ADH6, and how do they contribute to its function in alcohol metabolism?

The enzymatic kinetics and substrate specificity of ADH6 contribute to its function in alcohol metabolism, enabling efficient conversion of specific alcohol substrates.