AK8

  • Official Full Name

    adenylate kinase 8

  • Overview

    Adenylate kinase (EC 2.7.4.3) (also known as ADK or myokinase) is a phosphotransferase enzyme that catalyzes the interconversion of adenine nucleotides, and plays an important role in cellular energy homeostasis.

  • Synonyms

    DDX31;C9orf98;FLJ32704;FLJ36014;RP11-143F18.1;adenylate kinase 8;OTTHUMP00000022737;putative adenylate kinase-like protein C9orf98

Recombinant Proteins

  • Human
  • Mouse
  • Zebrafish
  • Cynomolgus
  • Rat
  • Wheat Germ
  • Mammalian Cells
  • HEK293
  • In Vitro Cell Free System
  • GST
  • His
  • Non
  • Avi
  • Fc

    Involved Pathway

    AK8 involved in several pathways and played different roles in them. We selected most pathways AK8 participated on our site, such as Biosynthesis of antibiotics,Metabolic pathways,Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with AK8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Purine metabolism PDE6A,POLR2E,GMPS,ADSSL,NT5C1A,PRPS1,ADCY1B,POLE,NT5C3L,PDE10A
    Synthesis and interconversion of nucleotide di- and triphosphates DTYMK,AK7A,AK7,GLRX,GRX2
    Metabolism of nucleotides NUDT18,DCK,DUT,AK7,PAICS,ADK,DPYDA.1,ADAL,TM9SF1,NUDT16
    adenosine ribonucleotides de novo biosynthesis ATP5S,ADSS,ATP5L,AK7,ADSSL1
    Biosynthesis of antibiotics NME6,DLST,PAICS,CMBL,LDHAL6B,ADH5,UAP1L1,ECHS1,CYP51A1,ADSL
    Metabolic pathways PTGES3A,POLR2K,INPP4AB,PLCD1A,FUT8A,CYP2C19,ALPI,DNMT3AA,ACO2,FUT1
    Metabolism LSM1,SCO1,SLC25A13,CYP27A1,NDUFAF3,PYGMB,GCHFR,NAMPT,NOSTRIN,PCBD1
    purine nucleotides de novo biosynthesis ATP5S,ADSSL1,AK7

    Protein Function

    AK8 has several biochemical functions, for example, ATP binding,adenylate kinase activity,cytidylate kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AK8 itself. We selected most functions AK8 had, and list some proteins which have the same functions with AK8. You can find most of the proteins on our site.

    Function Related Protein
    protein binding UBA1,TTI1,KRTAP9-4,PIP5K1C,MAPK8IP3,TUBA3E,USP49,MAP3K3,SLC35F6,NAMPT
    ATP binding DYNC2H1,LYN,DNAJA2L,ABCC11,TESK2,PCXB,DDX24,DDR2,ACSL4,PCCA
    adenylate kinase activity AK2,AK1,AK7,AK5,AK4
    nucleoside diphosphate kinase activity NME7,NME2,AK7,NME2B.1,NME2B.2,CMPK2,NME4,AK9,NME3,AK5
    cytidylate kinase activity CMPK,AK7,CMPK2,CMPK1

    Interacting Protein

    AK8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AK8 here. Most of them are supplied by our site. Hope this information will be useful for your research of AK8.

    CCDC102B;MCM7;MAP3K7CL;RBM39;RBM39;HAUS1;ZMAT2

    Resources

    References

    • Grueb, M; Rohrbach, JM; et al. Serotonin (5-HT7) Receptor-Stimulated Activation of cAMP-PKA Pathway in Bovine Corneal Epithelial and Endothelial Cells. OPHTHALMIC RESEARCH 48:22-27(2012).
    • Moteki, H; Kimura, M; et al. Activation of Extracellular-Signal Regulated Kinase by Epidermal Growth Factor Is Potentiated by cAMP-Elevating Agents in Primary Cultures of Adult Rat Hepatocytes. BIOLOGICAL & PHARMACEUTICAL BULLETIN 34:1542-1552(2011).

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