ak8
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  • Official Full Name
  • adenylate kinase 8
  • Background
  • Adenylate kinase (EC 2.7.4.3) (also known as ADK or myokinase) is a phosphotransferase enzyme that catalyzes the interconversion of adenine nucleotides, and plays an important role in cellular energy homeostasis.
  • Synonyms
  • DDX31; C9orf98; FLJ32704; FLJ36014; RP11-143F18.1; adenylate kinase 8; OTTHUMP00000022737; putative adenylate kinase-like protein C9orf98
Cat.#:AK8-0225HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human AK8 Protein, GST-Tagged
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Cat.#:AK8-1468MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse AK8 Protein
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Cat.#:AK8-586RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat AK8 Protein
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Cat.#:AK8-288CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus AK8 Protein, His-tagged
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Cat.#:AK8-2817ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish AK8
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Cat.#:AK8-264HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human AK8 cell lysate
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Involved Pathway

AK8 involved in several pathways and played different roles in them. We selected most pathways AK8 participated on our site, such as Biosynthesis of antibiotics, Metabolic pathways, Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with AK8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Biosynthesis of antibiotics
DBT; SDSL; LDHAL6B; BPNT1; AKR1A1; DLST; DLD; EHHADH; pykF; CTH
Metabolic pathways
TPH1A; EXT1; NDUFB3; CKMT1B; POLR2F; PCYT1AB; ADH2-2; ATP5C1; HPD; ALDH2
Metabolism
MED8; CDIPT; AGL; UPP2; AZIN1; COQ6; LYPLA1; SLC25A2; CERS3B; SCP2B
Metabolism of nucleotides
ADK; NUDT5; ADSS; PAICS; DGUOK; ITPA; DPYDA.1; AK8; DHODH; DPYS
Purine metabolism
PDE1A; XDH; ADCY1A; NT5C1B; POLR3F; NT5C; NT5C1B-RDH14; AMPD2; AMPD3B; PRPS1B
Synthesis and interconversion of nucleotide di- and triphosphates
GRX2; AK8; DTYMK; GLRX; AK7A; AK7
adenosine ribonucleotides de novo biosynthesis
ATP5L; AK8; ADSSL1; AK7; ATP5S; ADSS
purine nucleotides de novo biosynthesis
AK7; AK8; ADSSL1; ATP5S

Protein Function

AK8 has several biochemical functions, for example, ATP binding, adenylate kinase activity, cytidylate kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AK8 itself. We selected most functions AK8 had, and list some proteins which have the same functions with AK8. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein PMS1; CSNK1G3; MAP2K4; SCYL1; ACVR1; CDK11A; UBA1; XRCC6; ATAD2; MAP4K2
Function adenylate kinase activity
Related Protein AK8; AK5; AK2; AK4; AK1; AK7
Function cytidylate kinase activity
Related Protein CMPK1; AK8; CMPK2; AK7; CMPK
Function nucleoside diphosphate kinase activity
Related Protein NME4; NME2B.1; NME1; NME7; NME9; AK4; NME6; CMPK; NME8; CMPK2
Function protein binding
Related Protein DYSFIP1; MAD2L2; CCDC59; BAK1; ALOX5AP; JAKMIP1; ADAMTS5; HIST1H4L; PLIN3; CNIH2

Interacting Protein

AK8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AK8 here. Most of them are supplied by our site. Hope this information will be useful for your research of AK8.
CCDC102B; MCM7; MAP3K7CL; RBM39; RBM39; HAUS1; ZMAT2

AK8 Related Articles

Grueb, M; Rohrbach, JM; et al. Serotonin (5-HT7) Receptor-Stimulated Activation of cAMP-PKA Pathway in Bovine Corneal Epithelial and Endothelial Cells. OPHTHALMIC RESEARCH 48:22-27(2012).
Moteki, H; Kimura, M; et al. Activation of Extracellular-Signal Regulated Kinase by Epidermal Growth Factor Is Potentiated by cAMP-Elevating Agents in Primary Cultures of Adult Rat Hepatocytes. BIOLOGICAL & PHARMACEUTICAL BULLETIN 34:1542-1552(2011).