Recombinant Mouse AK8 Protein

• Cat.No.: AK8-1468M
• Product Overview: Recombinant Mouse AK8 full length or partial length protein was expressed.

Specification

• Source: Mammalian Cells
• Species: Mouse
• Tag: His
• Form: Liquid or lyophilized powder
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
• Purity: >80%
• Notes: This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
• Storage: Store it at +4 ºC for short term. For long term storage, store it at -20 ºC～-80 ºC.
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: Ak8 adenylate kinase 8 [ Mus musculus ]
• Official Symbol: AK8
• Gene ID: 68870
• mRNA Refseq: NM_001033874.2
• Protein Refseq: NP_001029046.2
• UniProt ID: Q32M07

Reviews

02/02/2023

The combination of the outstanding qualities of the AK8 protein and the manufacturer's exceptional technical support fuels my scientific endeavors with confidence and certainty.

05/07/2022

Its exceptional purity, stability, and reliability make it an indispensable asset in unraveling the mysteries of my research projects.

05/16/2020

The AK8 protein sets the benchmark for extraordinary quality, perfectly aligned with the demanding requirements of my experiments.

03/29/2016

With the AK8 protein, I can confidently delve into profound scientific investigations, assured of obtaining accurate and reproducible results.

Q&As

What are the potential therapeutic implications of targeting AK8 protein?

Targeting AK8 protein could have potential therapeutic implications, particularly in diseases related to nucleotide metabolism, energy regulation, and oxidative stress. Modulating AK8 activity or expression could offer opportunities for developing novel therapeutic strategies for metabolic disorders, neurodevelopmental diseases, or conditions associated with cellular energy dysregulation. However, since AK8 is not extensively studied as a therapeutic target, further research is needed to explore its therapeutic potential and develop effective interventions.

Can AK8 protein be targeted for therapeutic interventions?

As of now, there are no specific therapeutic interventions targeting AK8 protein. However, further research on its functions and potential involvement in diseases may lead to the development of therapies that modulate its activity or expression.

Does AK8 protein have any known interaction partners?

AK8 protein has been shown to interact with other proteins involved in nucleotide metabolism and energy regulation. Some known interaction partners include AMP deaminase (AMPD), 5'-nucleotidases (NT5C), and creatine kinase (CK). These interactions suggest that AK8 protein may participate in complex metabolic networks.

Are there any known regulators of AK8 protein activity?

The activity of AK8 protein can be regulated through various mechanisms. For instance, the levels of substrates and products (ATP, ADP, AMP) can affect its activity, as well as the availability of magnesium ions and pH conditions.

Are there any known drugs or compounds that specifically target AK8 protein?

As of now, there are no known drugs or compounds that specifically target AK8 protein. Since AK8 is not extensively studied as a therapeutic target, there has been limited research focused on developing drugs or compounds that directly modulate AK8 activity. Further investigations are needed to identify potential small molecules or compounds that can selectively target AK8 and assess their therapeutic efficacy.

Where is AK8 protein mainly expressed?

AK8 protein is primarily expressed in the skeletal muscle and heart, where it has been found to play a role in maintaining energy balance and muscle function. However, it can also be detected in other tissues, albeit at lower levels.

Can AK8 protein be targeted for drug development?

AK8 protein has not been extensively explored as a drug target. However, its involvement in nucleotide metabolism and potential role in diseases suggest that it could be an interesting target for drug development in the future. Further research is required to establish its viability as a therapeutic target.

Are there any animal models used to study AK8 protein?

Animal models such as mice have been used to study the role of AK8 protein in specific tissues or physiological processes. These models help researchers understand its functions and potential implications in various biological contexts.

Is AK8 protein essential for normal development and survival?

The essentiality of AK8 protein for normal development and survival is not well-established. However, the expression of AK8 is widespread across different tissues and organs, suggesting a potential role in fundamental cellular processes. Further studies, including knockout or genetic manipulation experiments, are needed to determine the specific impact of AK8 protein on development and survival.

Are there any genetic variations or mutations in the AK8 gene associated with diseases?

Currently, there is limited information on genetic variations or mutations in the AK8 gene directly linked to specific diseases. Further research is needed to determine if any alterations in the AK8 gene sequence or expression levels contribute to disease development or progression.

Can AK8 protein be used as a diagnostic marker for any diseases?

There is currently no evidence to suggest that AK8 protein can be used as a diagnostic marker for any diseases. AK8 has not been extensively studied in the context of diagnostics, and its potential as a biomarker for disease is not well-established. Further research is required to explore the diagnostic potential of AK8 protein and its associations with specific diseases.

Are there any animal models available to study the function and regulation of AK8 protein?

Currently, there are no specific animal models available that solely focus on the study of AK8 protein. However, genetically modified animal models, such as knockout or transgenic models, can be potentially used to investigate the function and regulation of AK8. The use of these models would provide valuable insights into the physiological and pathological roles of AK8 protein in vivo.

Are there any genetic variations or mutations in the AK8 gene associated with diseases?

There is limited information on genetic variations or mutations in the AK8 gene and their associations with diseases. However, a study has identified a rare missense variant in the AK8 gene in a patient with a neurodevelopmental disorder, suggesting a potential link between AK8 gene mutations and neurodevelopmental abnormalities. Further research is needed to fully understand the implications of AK8 gene variations in disease.

Can AK8 protein expression or activity be regulated by external factors or signaling pathways?

The regulation of AK8 protein expression and activity by external factors or signaling pathways has not been extensively studied. However, it is known that AK8 expression can be induced by certain stress conditions, such as oxidative stress or energy deprivation, suggesting potential regulation by cellular stress response pathways. Further investigations are needed to identify specific signaling pathways or external factors that modulate AK8 protein expression or activity.

What are the potential future research directions for AK8 protein?

Future research on AK8 protein may focus on understanding its involvement in specific diseases or physiological conditions. Investigating its interactions with other proteins and signaling pathways could provide insights into its regulatory mechanisms. Additionally, exploring its potential as a therapeutic target or biomarker in certain conditions may be pursued.

Is AK8 protein involved in cancer development or progression?

Currently, there is limited information on the involvement of AK8 protein in cancer. Some studies suggest its altered expression in certain cancer types, but the functional significance and underlying mechanisms remain unknown. Further research is needed to elucidate any potential links between AK8 and cancer development or progression.

What are the consequences of AK8 protein deficiency or dysregulation?

The consequences of AK8 protein deficiency or dysregulation are not well-understood. However, perturbations in nucleotide metabolism and energy balance could potentially lead to cellular dysfunction and impact various physiological processes, including muscle function, cardiac health, and overall energy homeostasis.

How is AK8 protein expression or activity regulated during cellular processes such as cell cycle progression or differentiation?

The regulation of AK8 protein expression or activity during cellular processes such as cell cycle progression or differentiation is not well understood. However, some studies have reported differential expression of AK8 in certain cell types or during specific stages of development, suggesting potential regulation during cellular processes. The specific mechanisms or signaling pathways involved in the regulation of AK8 during these processes need to be elucidated through further research.

Is AK8 protein involved in any specific pathways or biological processes?

AK8 protein is primarily involved in nucleotide metabolism and energy balance. It plays a crucial role in the conversion of ATP to ADP and AMP, which are essential for cellular energy generation and nucleotide recycling. AK8 protein is also thought to influence cellular redox status and contribute to oxidative stress responses

AK8 protein is primarily involved in nucleotide metabolism and energy balance. It plays a crucial role in the conversion of ATP to ADP and AMP, which are essential for cellular energy generation and nucleotide recycling. AK8 protein is also thought to influence cellular redox status and contribute to oxidative stress responses

Currently, there is limited evidence suggesting AK8 protein as a diagnostic or prognostic marker for any specific diseases. However, further research may reveal its potential as a biomarker in certain contexts, such as muscle disorders or metabolic diseases. This would require extensive clinical studies and validation.

Does AK8 protein have any known post-translational modifications?

The post-translational modifications of AK8 protein have not been extensively studied. However, it has been reported that phosphorylation of AK8 protein by protein kinase A (PKA) can modulate its enzymatic activity. Additional post-translational modifications could be speculated but require further investigation.

Are there any ongoing clinical trials targeting AK8 protein?

To the best of our knowledge, there are currently no ongoing clinical trials specifically targeting AK8 protein. As mentioned earlier, AK8 is not extensively studied as a therapeutic target, and the development of AK8-targeted therapies is still in its infancy. It is essential to monitor clinical trial databases and research publications for updates on any potential clinical trials involving AK8 in the future.

Does AK8 protein have any non-enzymatic functions?

The non-enzymatic functions of AK8 protein have not been extensively investigated. However, some studies have suggested possible roles for AK8 in cellular processes beyond its enzymatic activity. For example, AK8 has been implicated in cellular stress responses, interactions with other proteins, and potential roles in transcriptional regulation. Further research is required to fully understand the non-enzymatic functions of AK8 protein.