AKAP1
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Official Full Name
A kinase (PRKA) anchor protein 1
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Overview
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to type I and type II regulatory subunits of PKA and anchors them to the mitochondrion. This protein is speculated to be involved in the cAMP-dependent signal transduction pathway and in directing RNA to a specific cellular compartment. -
Synonyms
AKAP1; A kinase (PRKA) anchor protein 1; PRKA1; A-kinase anchor protein 1, mitochondrial; AKAP84; AKAP121; AKAP149; D AKAP1; dual specificity A kinase anchoring protein 1; PPP1R43; protein kinase anchoring protein 1; protein phosphatase 1; regulatory subunit 43; S AKAP84; SAKAP84; A kinase anchor protein; AKAP 149; AKAP; DAKAP1; Protein kinase A1; D-AKAP-1; A-kinase anchor protein 149 kDa; protein kinase A anchoring protein 1; spermatid A-kinase anchor protein 84; protein phosphatase 1, regulatory subunit 43; dual-specificity A-kinase anchoring protein 1; D-AKAP1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Rhesus Macaque
- E.coli
- E.Coli or Yeast
- HEK293
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- AKAP1 Related Articles
AKAP1 involved in several pathways and played different roles in them. We selected most pathways AKAP1 participated on our site, such as Factors involved in megakaryocyte development and platelet production, G Protein Signaling Pathways, Hemostasis, which may be useful for your reference. Also, other proteins which involved in the same pathway with AKAP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Factors involved in megakaryocyte development and platelet production | H3F3B.1;MAFF;PHF21A;HBE1;DOCK10;H3F3D;BA1L;DOCK8;KIFC1 |
G Protein Signaling Pathways | Akap2;GNGT2A;AKAP12B;AKAP10;GNB3B;GNB5B;AKAP1B;AKAP1;AKAP4 |
Hemostasis | DOCK6;MFN2;IGF2B;DGKG;RHOGA;DOCK9;KIF20A;TRPC6A;BA1 |
AKAP1 has several biochemical functions, for example, RNA binding, beta-tubulin binding, microtubule binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AKAP1 itself. We selected most functions AKAP1 had, and list some proteins which have the same functions with AKAP1. You can find most of the proteins on our site.
Function | Related Protein |
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RNA binding | RPL9;GRB7;RBFOX1;FBL;RPL27A;RNASEH1;RBM4.1;TTC6;POP4 |
beta-tubulin binding | SNCA;GABARAPL1;BBS4;SERPINB1A;HDAC6;OST4;PACRG;RGS2;RANBP10 |
microtubule binding | WDR81;KIF15;NUMA1;KIF2A;APC;NDEL1;WHAMM;KIF19;CEP57 |
poly(A) RNA binding | DDX47;ANKRD17;HDGF;SRPK1;RPUSD2;C1orf131;RARS2;NOL12;CCT4 |
protein binding | TAE1;HELZ;CCDC155;MTAP;SPG7;RANBP6;HHLA3;XPO5;FKBP1B |
protein complex scaffold | SMARCD1;C9orf142;CAV2;KLHL17;WWC1;SEPT2;MAGI1;SLC9A1;DLG1 |
protein domain specific binding | ZNF521;HIST1H4D;WNT1;TFDP2;RQCD1;CSNK2B;SKIL;Akap2;ICA1L |
protein kinase A regulatory subunit binding | RYR2;AKAP5;AKAP7;PJA2;AKAP6;AKAP8;ACBD3;EZR;ARFGEF2 |
protein kinase binding | CCNL1A;FBXO7;MAP3K1;CDC25A;RAD9;POLA1;MAP2K7;LAT;SNAP91 |
protein phosphatase 2B binding | BAD;PPP3CB;SLC9A1;AKAP1;SOD1;AKAP5;MYOZ2;ATP2B4 |
AKAP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AKAP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AKAP1.
PRKAR2A; PRKACA; Siah2; USP7; DYSF; PRKAR1A; p29991-pro_0000037941; MYCBP; 3',5'-cyclic amp; 2_aha_camp; 8-aha-camp
- Q&As
- Reviews
Q&As (19)
Ask a questionAKAP1 interacts with multiple binding partners, including protein kinase A (PKA), protein kinase C (PKC), protein phosphatase 1 (PP1), collapsin response mediator protein (CRMP), and phospholamban (PLN). These interactions are essential for AKAP1's role in coordinating signaling pathways and regulating various cellular processes.
Some studies have suggested that dysregulation of AKAP1 could contribute to certain diseases. For example, altered AKAP1 expression has been observed in cardiovascular diseases, cancer, and neurodegenerative disorders. However, the specific roles and mechanisms of AKAP1 in these pathologies are still being investigated, and further research is needed to fully understand the implications of AKAP1 in disease processes.
AKAP1 has been shown to be involved in both apoptosis (programmed cell death) and cell survival. Its interactions with PKA and PKC can affect cell survival pathways, while its anchoring of PP1 can influence apoptotic processes. However, the precise mechanisms and the context-dependent effects of AKAP1 in apoptosis and cell survival require further investigation.
AKAP1's involvement in cancer is still being studied, but it has been implicated in various types of cancer. Altered AKAP1 expression has been observed in breast cancer, prostate cancer, and leukemia. AKAP1's role in regulating cell cycle progression, cell migration, and protein phosphorylation suggests that its dysregulation could contribute to cancer development and progression.
While the majority of studies indicate a tumor suppressor role for AKAP1, some evidence suggests its potential involvement as an oncogene in certain contexts. One possible mechanism is through its influence on cell migration and metastasis. AKAP1 has been shown to interact with components of the actin cytoskeleton and focal adhesion complexes, promoting cell motility and invasive behavior. These characteristics are important for cancer cells to escape the primary tumor and metastasize to distant sites.
AKAP1 facilitates signal transduction by anchoring protein kinases such as PKA and PKC to specific locations within the cell. This localization enables efficient and localized phosphorylation of target proteins, modulating downstream signaling events.
The dualistic nature of AKAP1's involvement in various cellular processes suggests that it may have context-dependent effects in tumorigenesis. Some studies have proposed that AKAP1 functions as a tumor suppressor, while others have suggested its potential role as an oncogene. Further research is needed to fully elucidate its role in cancer development and progression.
AKAP1 has been shown to interact with cyclin-dependent kinases (CDKs) and cyclins, which are key regulators of the cell cycle. By anchoring these molecules, AKAP1 helps to coordinate their activity and ensure proper progression through the various phases of the cell cycle. Disruption of AKAP1 function can lead to cell cycle abnormalities and dysregulated cell proliferation.
The precise targeting of AKAP1 for drug development is still an area of active research. Since AKAP1 is involved in various cellular processes and interacts with multiple signaling molecules, it has the potential to serve as a therapeutic target. However, more studies are needed to better understand AKAP1's specific functions and its interactions with other proteins to identify potential drug targets and develop therapeutic strategies.
Yes, some genetic variations in AKAP1 have been identified. For example, a single nucleotide polymorphism (SNP) in AKAP1 has been associated with an increased risk of chronic lymphocytic leukemia. Additional studies are needed to further elucidate the potential genetic variations and their impact on AKAP1 function and disease susceptibility.
Yes, AKAP1 has a role in cardiac function and has been found to be highly expressed in the heart. It interacts with various proteins involved in cardiac signaling and contraction, including PKA, protein phosphatase 1 (PP1), and phospholamban (PLN). AKAP1's anchoring of PKA facilitates the phosphorylation of target proteins involved in cardiac excitation-contraction coupling.
One potential mechanism through which AKAP1 may function as a tumor suppressor is by regulating cell cycle progression. AKAP1 has been shown to interact with cyclins and CDKs, key regulators of the cell cycle. Its knockdown has been associated with cell cycle arrest, suggesting that it may prevent uncontrolled cell proliferation and tumor growth.
AKAP1 has been implicated in cell migration, particularly in the context of cancer metastasis. It interacts with components of the actin cytoskeleton and focal adhesion complexes, influencing cell motility and invasive behavior. However, the specific mechanisms through which AKAP1 regulates cell migration require further investigation.
Yes, AKAP1 has been shown to play a role in cell cycle control. It interacts with proteins involved in cell cycle progression, such as cyclins and cyclin-dependent kinases (CDKs), and its knockdown has been associated with cell cycle arrest at specific phases.
Currently, no specific disease-causing mutations in the AKAP1 gene have been documented. However, certain studies have suggested that alterations in AKAP1 expression and function may contribute to various diseases, including cancer, cardiovascular disorders, and neurological disorders. Further research is needed to explore the potential involvement of AKAP1 mutations in disease mechanisms.
Yes, AKAP1 has been implicated in neuronal development and axon guidance. It interacts with signaling molecules involved in neurite outgrowth and axon guidance, such as protein kinase C (PKC) and collapsin response mediator protein (CRMP). AKAP1 localization and its interaction with PKA and other proteins contribute to the spatial and temporal regulation of signaling that is critical for proper neuronal development.
As of now, there are no known drugs or experimental compounds specifically designed to modulate AKAP1 activity. However, researchers are actively exploring the potential of targeting AKAP1 for therapeutic purposes, and future studies may identify compounds that can selectively regulate its function.
AKAP1 plays a role in various cellular processes, including signal transduction, gene regulation, cell cycle control, and cell migration. It acts as a molecular scaffold, anchoring protein kinases and phosphatases to specific subcellular locations, allowing for the coordination of signaling pathways.
The precise targeting of AKAP1 for therapeutic purposes is currently not well-established. However, given its crucial role in regulating PKA signaling and its involvement in various cellular processes, it is possible that modulating AKAP1 or its interactions could have therapeutic potential. Further research is needed to explore and develop strategies to target AKAP1 for therapeutic interventions.
Customer Reviews (4)
Write a reviewIts purity and stability ensure reliable and reproducible results.
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