AKAP1 Protein, A kinase (PRKA) anchor protein 1

AKAP1

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AKAP1

Official Full Name A kinase (PRKA) anchor protein 1
Background The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to type I and type II regulatory subunits of PKA and anchors them to the mitochondrion. This protein is speculated to be involved in the cAMP-dependent signal transduction pathway and in directing RNA to a specific cellular compartment.
Synonyms AKAP1; A kinase (PRKA) anchor protein 1; PRKA1; A-kinase anchor protein 1, mitochondrial; AKAP84; AKAP121; AKAP149; D AKAP1; dual specificity A kinase anchoring protein 1; PPP1R43; protein kinase anchoring protein 1; protein phosphatase 1; regulatory subunit 43; S AKAP84; SAKAP84; A kinase anchor protein; AKAP 149; AKAP; DAKAP1; Protein kinase A1; D-AKAP-1; A-kinase anchor protein 149 kDa; protein kinase A anchoring protein 1; spermatid A-kinase anchor protein 84; protein phosphatase 1, regulatory subunit 43; dual-specificity A-kinase anchoring protein 1; D-AKAP1
    • Species :
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • E.Coli or Yeast
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human AKAP1-395H Recombinant Human AKAP1 Protein, GST-tagged Wheat Germ GST
    Human AKAP1-8942HCL Recombinant Human AKAP1 293 Cell Lysate HEK293 N/A
    Human AKAP1-9517H Recombinant Human AKAP1, His-tagged E.coli His
    Mouse AKAP1-1469M Recombinant Mouse AKAP1 Protein Mammalian Cell His
    Rat Akap1-3019R Recombinant Rat Akap1, His-tagged E.Coli or Yeast His
    Rat AKAP1-587R Recombinant Rat AKAP1 Protein Mammalian Cell His
    Rhesus Macaque AKAP1-286R Recombinant Rhesus monkey AKAP1 Protein, His-tagged Mammalian Cell His

    AKAP1 involved in several pathways and played different roles in them. We selected most pathways AKAP1 participated on our site, such as Factors involved in megakaryocyte development and platelet production, G Protein Signaling Pathways, Hemostasis, which may be useful for your reference. Also, other proteins which involved in the same pathway with AKAP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Factors involved in megakaryocyte development and platelet production DOCK9; MAFGA; SH2B3; HMG20B; AKAP1; CENPE; CABLES1; IRF1B; HBE1; EHD1
    G Protein Signaling Pathways GNG13B; GNB5B; AKAP4; GNA13; AKAP13; KCNJ3; AKAP1; AKAP6; GNGT2A; Akap2
    Hemostasis GATA1; TRPC6A; F9A; D-AKAP2; HBBE3; MYB; SERPINB8; CEACAM6; AMICA1; KCNMA1

    AKAP1 has several biochemical functions, for example, RNA binding, beta-tubulin binding, microtubule binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AKAP1 itself. We selected most functions AKAP1 had, and list some proteins which have the same functions with AKAP1. You can find most of the proteins on our site.

    Function Related Protein
    RNA binding RPL19; LOC81691; ENDOU2; DPPA5; NOL3; IGF2BP2A; C14orf166; IFIT11; SFPI1; AHCYL1
    beta-tubulin binding FGF13; ADNP; PROL1; CCT5; PACRG; B4GALT1; RACGAP1; SERPINB1A; VAPB; PEX14
    microtubule binding RPS3; PEX14; CDK5RAP2; MAP205; KATNAL2; KIF13B; KIF26A; GAS2L3; KIF7; KIF9
    poly(A) RNA binding SSRP1; CDK13; PDAP1; ISG20L2; HDGF; ZCCHC11; FBL; NSA2; MBNL2; RPL13
    protein binding BRMS1; HTATIP2; CUL9; ORC2L; TBC1D16; PGAP2; DHX36; RPS6KA1; COMMD10; SSRP1
    protein complex scaffold SLC9A3R2; MPP7; MAGI3; DISC1; WWC3; ISCU; SLC9A1; WWC2; AKAP13; CAV2
    protein domain specific binding TACC1; CALM1; TRIM11; POU2F2; ZFP521; TWIST2; SCAF1; ARR3; CHMP1A; CENPJ
    protein kinase A regulatory subunit binding PJA2; ACBD3; AKAP7; KCNQ1; AKAP6; PRKACA; AKAP5; RYR2; EZR; AKAP1
    protein kinase binding TRAF2; CAMK2N1; LIPE; DOK7; PTPN6; ITGB2; MAP3K5; GATA4; PPP1R15A; FOXM1
    protein phosphatase 2B binding ATP2B4; BAD; AKAP5; MYOZ2; SOD1; PPP3CB; SLC9A1; AKAP1

    AKAP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AKAP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AKAP1.

    PRKAR2A; PRKACA; Siah2; USP7; DYSF; PRKAR1A; p29991-pro_0000037941; MYCBP; 3',5'-cyclic amp; 2_aha_camp; 8-aha-camp

    Sotgia, F; Whitaker-Menezes, D; et al. Mitochondria "fuel" breast cancer metabolism Fifteen markers of mitochondrial biogenesis label epithelial cancer cells, but are excluded from adjacent stromal cells. CELL CYCLE 11:4390-4401(2012).
    Reinton, N; Collas, P; et al. Localization of a novel human A-kinase-anchoring protein, hAKAP220, during spermatogenesis. DEVELOPMENTAL BIOLOGY 223:194-204(2000).

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