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Recombinant Rat AKAP1 Protein

Cat.No. : AKAP1-587R
Product Overview : Recombinant Rat AKAP1 full length or partial length protein was expressed.
  • Specification
  • Gene Information
  • Related Products
Source : Mammalian Cells
Species : Rat
Tag : His
Form : Liquid or lyophilized powder
Endotoxin : < 1.0 EU per μg of the protein as determined by the LAL method.
Purity : >80%
Notes : This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
Storage : Store it at +4 ºC for short term. For long term storage, store it at -20 ºC~-80 ºC.
Storage Buffer : PBS buffer
Gene Name : Akap1 A kinase (PRKA) anchor protein 1 [ Rattus norvegicus ]
Official Symbol : AKAP1
Gene ID : 114124
mRNA Refseq : NM_053665.1
Protein Refseq : NP_446117.1
MIM :
UniProt ID : O88884

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (19)

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Are there any known binding partners of AKAP1? 05/28/2023

AKAP1 interacts with multiple binding partners, including protein kinase A (PKA), protein kinase C (PKC), protein phosphatase 1 (PP1), collapsin response mediator protein (CRMP), and phospholamban (PLN). These interactions are essential for AKAP1's role in coordinating signaling pathways and regulating various cellular processes.

Is AKAP1 involved in any diseases or pathological conditions? 05/27/2023

Some studies have suggested that dysregulation of AKAP1 could contribute to certain diseases. For example, altered AKAP1 expression has been observed in cardiovascular diseases, cancer, and neurodegenerative disorders. However, the specific roles and mechanisms of AKAP1 in these pathologies are still being investigated, and further research is needed to fully understand the implications of AKAP1 in disease processes.

Does AKAP1 play a role in apoptosis or cell survival? 06/06/2022

AKAP1 has been shown to be involved in both apoptosis (programmed cell death) and cell survival. Its interactions with PKA and PKC can affect cell survival pathways, while its anchoring of PP1 can influence apoptotic processes. However, the precise mechanisms and the context-dependent effects of AKAP1 in apoptosis and cell survival require further investigation.

Does AKAP1 have any role in cancer? 02/26/2022

AKAP1's involvement in cancer is still being studied, but it has been implicated in various types of cancer. Altered AKAP1 expression has been observed in breast cancer, prostate cancer, and leukemia. AKAP1's role in regulating cell cycle progression, cell migration, and protein phosphorylation suggests that its dysregulation could contribute to cancer development and progression.

What are the potential mechanisms by which AKAP1 functions as an oncogene? 05/22/2021

While the majority of studies indicate a tumor suppressor role for AKAP1, some evidence suggests its potential involvement as an oncogene in certain contexts. One possible mechanism is through its influence on cell migration and metastasis. AKAP1 has been shown to interact with components of the actin cytoskeleton and focal adhesion complexes, promoting cell motility and invasive behavior. These characteristics are important for cancer cells to escape the primary tumor and metastasize to distant sites.

How is AKAP1 involved in signal transduction? 08/30/2020

AKAP1 facilitates signal transduction by anchoring protein kinases such as PKA and PKC to specific locations within the cell. This localization enables efficient and localized phosphorylation of target proteins, modulating downstream signaling events.

Can AKAP1 function as a tumor suppressor or oncogene? 03/15/2020

The dualistic nature of AKAP1's involvement in various cellular processes suggests that it may have context-dependent effects in tumorigenesis. Some studies have proposed that AKAP1 functions as a tumor suppressor, while others have suggested its potential role as an oncogene. Further research is needed to fully elucidate its role in cancer development and progression.

How is AKAP1 involved in cell cycle regulation? 12/08/2019

AKAP1 has been shown to interact with cyclin-dependent kinases (CDKs) and cyclins, which are key regulators of the cell cycle. By anchoring these molecules, AKAP1 helps to coordinate their activity and ensure proper progression through the various phases of the cell cycle. Disruption of AKAP1 function can lead to cell cycle abnormalities and dysregulated cell proliferation.

Can AKAP1 be targeted for drug development? 09/06/2019

The precise targeting of AKAP1 for drug development is still an area of active research. Since AKAP1 is involved in various cellular processes and interacts with multiple signaling molecules, it has the potential to serve as a therapeutic target. However, more studies are needed to better understand AKAP1's specific functions and its interactions with other proteins to identify potential drug targets and develop therapeutic strategies.

Are there any genetic mutations or polymorphisms associated with AKAP1? 08/22/2019

Yes, some genetic variations in AKAP1 have been identified. For example, a single nucleotide polymorphism (SNP) in AKAP1 has been associated with an increased risk of chronic lymphocytic leukemia. Additional studies are needed to further elucidate the potential genetic variations and their impact on AKAP1 function and disease susceptibility.

Is AKAP1 involved in cardiac function? 05/20/2018

Yes, AKAP1 has a role in cardiac function and has been found to be highly expressed in the heart. It interacts with various proteins involved in cardiac signaling and contraction, including PKA, protein phosphatase 1 (PP1), and phospholamban (PLN). AKAP1's anchoring of PKA facilitates the phosphorylation of target proteins involved in cardiac excitation-contraction coupling.

What are the potential mechanisms by which AKAP1 functions as a tumor suppressor? 03/17/2018

One potential mechanism through which AKAP1 may function as a tumor suppressor is by regulating cell cycle progression. AKAP1 has been shown to interact with cyclins and CDKs, key regulators of the cell cycle. Its knockdown has been associated with cell cycle arrest, suggesting that it may prevent uncontrolled cell proliferation and tumor growth.

How does AKAP1 contribute to cell migration? 11/18/2017

AKAP1 has been implicated in cell migration, particularly in the context of cancer metastasis. It interacts with components of the actin cytoskeleton and focal adhesion complexes, influencing cell motility and invasive behavior. However, the specific mechanisms through which AKAP1 regulates cell migration require further investigation.

Does AKAP1 have any involvement in cell cycle control? 11/07/2017

Yes, AKAP1 has been shown to play a role in cell cycle control. It interacts with proteins involved in cell cycle progression, such as cyclins and cyclin-dependent kinases (CDKs), and its knockdown has been associated with cell cycle arrest at specific phases.

Are there any known mutations in the AKAP1 gene associated with human diseases? 07/27/2017

Currently, no specific disease-causing mutations in the AKAP1 gene have been documented. However, certain studies have suggested that alterations in AKAP1 expression and function may contribute to various diseases, including cancer, cardiovascular disorders, and neurological disorders. Further research is needed to explore the potential involvement of AKAP1 mutations in disease mechanisms.

Can AKAP1 affect neuronal development? 11/01/2016

Yes, AKAP1 has been implicated in neuronal development and axon guidance. It interacts with signaling molecules involved in neurite outgrowth and axon guidance, such as protein kinase C (PKC) and collapsin response mediator protein (CRMP). AKAP1 localization and its interaction with PKA and other proteins contribute to the spatial and temporal regulation of signaling that is critical for proper neuronal development.

Are there any drugs or experimental compounds known to modulate AKAP1 activity? 08/21/2016

As of now, there are no known drugs or experimental compounds specifically designed to modulate AKAP1 activity. However, researchers are actively exploring the potential of targeting AKAP1 for therapeutic purposes, and future studies may identify compounds that can selectively regulate its function.

What are the functions of AKAP1 in cellular processes? 01/18/2016

AKAP1 plays a role in various cellular processes, including signal transduction, gene regulation, cell cycle control, and cell migration. It acts as a molecular scaffold, anchoring protein kinases and phosphatases to specific subcellular locations, allowing for the coordination of signaling pathways.

Can AKAP1 be targeted for therapeutic purposes? 02/14/2015

The precise targeting of AKAP1 for therapeutic purposes is currently not well-established. However, given its crucial role in regulating PKA signaling and its involvement in various cellular processes, it is possible that modulating AKAP1 or its interactions could have therapeutic potential. Further research is needed to explore and develop strategies to target AKAP1 for therapeutic interventions.

Customer Reviews (4)

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Reviews
05/03/2022

    Its purity and stability ensure reliable and reproducible results.

    12/17/2021

      I am confident that the AKAP1 protein will be a valuable asset for my experiments as it exhibits outstanding quality.

      03/09/2019

        Their expertise and prompt assistance have consistently helped to overcome any hurdles and ensure the success of my research endeavors.

        02/03/2018

          I am highly satisfied with the AKAP1 protein and the support provided, making it an ideal choice for my experimental needs.

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