Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at BIO-Europe Spring|March 18–20, 2024|Booth #34

AKAP6

  • Official Full Name

    A kinase (PRKA) anchor protein 6

  • Overview

    The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of;binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within;the cell. This gene encodes a member of the AKAP family. The encoded protein is highly expressed in various brain;regions and cardiac and skeletal muscle. It is specifically localized to the sarcoplasmic reticulum and nuclear;membrane, and is involved in anchoring PKA to the nuclear membrane or sarcoplasmic reticulum.
  • Synonyms

    AKAP6; A kinase (PRKA) anchor protein 6; A-kinase anchor protein 6; ADAP6; AKAP100; KIAA0311; mAKAP; PRKA6; protein kinase A anchoring protein 6; AKAP-6; AKAP 100; A-kinase anchor protein 100 kDa; protein kinase A-anchoring protein 6; ADAP100; MGC165020;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Rat
  • E.coli
  • HEK293
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human AKAP6-715H Recombinant Human AKAP6 Mammalian Cell His
Human AKAP6-9523H Recombinant Human AKAP6, GST-tagged E.coli GST 1-350a.a.
Human AKAP6-32H Recombinant Human AKAP6 protein, GST-tagged Wheat Germ GST
Human AKAP6-2452H-B Recombinant Human AKAP6 Protein Pre-coupled Magnetic Beads HEK293
Human AKAP6-2452H Recombinant Human AKAP6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat AKAP6-592R Recombinant Rat AKAP6 Protein Mammalian Cell His
Rat AKAP6-248R-B Recombinant Rat AKAP6 Protein Pre-coupled Magnetic Beads HEK293
Rat AKAP6-248R Recombinant Rat AKAP6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein

AKAP6 involved in several pathways and played different roles in them. We selected most pathways AKAP6 participated on our site, such as G Protein Signaling Pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with AKAP6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
G Protein Signaling PathwaysGNG13B;KCNJ3;AKAP1B;GNA13;AKAP7;GNB5B;AKAP5;ARHGEF1A;AKAP13

AKAP6 has several biochemical functions, for example, adenylate cyclase binding, ion channel binding, protein anchor. Some of the functions are cooperated with other proteins, some of the functions could acted by AKAP6 itself. We selected most functions AKAP6 had, and list some proteins which have the same functions with AKAP6. You can find most of the proteins on our site.

Function Related Protein
adenylate cyclase bindingAKAP12;CALM2;AKAP5;CHRNA7;CALM1;AKAP6;CALM3;ADRB2;ADCYAP1R1
ion channel bindingDIAP1;SCN3B;CALM;PHPT1;LYN;ACTN4;CIB1;CHERP;SNTA1
protein anchorSUN1;AKAP6;PDCD6;ALG14;CIB1;NUP153;SUN5;MYH9;SLC4A1
protein bindingTBC1D24;APITD1;WBSCR27;NEDD9;ZNF16;HIPK4;RPL14;FGFBP1;ABCG8
protein complex scaffoldCHCHD3;WWC2;MPP7;AKAP13;WWC3;MAP2K2;MAGI1B;ARRB2;CAPN3
protein kinase A bindingAKAP4;Akap2;RPS3;LRRK2;AKAP14;MYRIP;DACT1;AKAP7;AKAP12
protein kinase A regulatory subunit bindingRYR2;AKAP9;ARFGEF2;AKAP5;PJA2;ARFGEF1;AKAP6;EZR;AKAP7

AKAP6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AKAP6 here. Most of them are supplied by our site. Hope this information will be useful for your research of AKAP6.

  • Q&As
  • Reviews

Q&As (19)

Ask a question
Are there any ongoing clinical trials targeting AKAP6? 12/22/2022

Currently, there are no clinical trials specifically targeting AKAP6. Clinical trials typically focus on testing therapeutic interventions in humans, and as of now, the knowledge about AKAP6's role in neurological disorders is still preliminary.

Where is AKAP6 primarily expressed? 09/03/2022

AKAP6 is expressed primarily in the brain, particularly in the hippocampus and cortex. It is highly enriched in neuronal dendrites, where it plays a role in regulating synaptic signaling and plasticity.

Can AKAP6 be regulated by post-translational modifications? 09/02/2022

Yes, AKAP6 can undergo post-translational modifications, including phosphorylation and palmitoylation. These modifications can regulate its interactions with binding partners and its subcellular localization, thereby modulating its functions.

Is AKAP6 associated with any diseases or pathological conditions? 03/02/2022

AKAP6 has been implicated in several neurological disorders, including schizophrenia, bipolar disorder, and autism spectrum disorders. Dysregulation of AKAP6 may contribute to abnormal synaptic signaling and neuronal circuitry, leading to these diseases. However, the exact mechanisms and causative roles of AKAP6 in these conditions are still being investigated.

What are the functions of AKAP6? 02/20/2022

AKAP6 functions as a scaffold protein that organizes multiple signaling molecules, including PKA, NMDA receptors, and ion channels, to specific subcellular locations. It is involved in the regulation of synaptic plasticity, neuronal excitability, and ion channel activity. AKAP6 has also been implicated in the development and remodeling of neuronal circuitry.

What are the mechanisms by which AKAP6 regulates synaptic plasticity? 12/05/2021

AKAP6 has been shown to regulate synaptic plasticity through its interactions with proteins involved in synaptic signaling. One mechanism is through its interaction with NMDA receptors, where AKAP6 recruits PKA to phosphorylate and modulate the activity of these receptors, influencing synaptic strength and plasticity. AKAP6 can also interact with L-type calcium channels and regulate their localization and activity, further impacting synaptic plasticity.

Does AKAP6 interact with other proteins? 05/11/2021

Yes, AKAP6 interacts with various proteins to fulfill its functions. It directly binds to PKA regulatory subunits and targets PKA to specific subcellular compartments. AKAP6 also interacts with NMDA receptors, L-type calcium channels, and other ion channels, as well as other AKAPs and cytoskeletal proteins.

What are the potential future directions for research on AKAP6? 09/01/2020

Future research on AKAP6 could explore several areas. One direction could be further investigating the molecular mechanisms by which AKAP6 regulates synaptic plasticity, exploring its interactions with different signaling molecules, and deciphering its downstream signaling pathways.

How is AKAP6 involved in neuronal excitability? 06/26/2020

AKAP6 is involved in regulating neuronal excitability through its interactions with ion channels. For example, AKAP6 can interact with L-type calcium channels and modulate their activity, affecting calcium influx and neuronal excitability. AKAP6 can also interact with other ion channels, such as potassium channels, and impact their function. Alterations in AKAP6 expression or function can lead to dysregulation of neuronal excitability.

Is AKAP6 conserved across different species? 01/27/2020

AKAP6 is conserved across different species, including mammals. However, there might be some variations in its structure and functions among different organisms.

Can AKAP6 be a potential therapeutic target for neurological disorders? 03/19/2019

AKAP6 has the potential to be a therapeutic target for neurological disorders. By understanding its functions and interactions with other signaling molecules, it may be possible to develop targeted interventions to modulate AKAP6 activity and restore normal neuronal function. However, more research is needed to fully elucidate the mechanisms and determine the feasibility of targeting AKAP6 for therapeutic purposes.

Are there any animal models or genetic studies investigating the role of AKAP6? 11/09/2018

Yes, there have been animal models and genetic studies investigating the role of AKAP6. Animal models, such as mice, have been used to study the effects of AKAP6 knockout or overexpression on neuronal function and behavior. These studies have provided insights into the molecular and cellular mechanisms by which AKAP6 regulates synaptic plasticity, neuronal excitability, and behavior. Additionally, genetic studies have examined variations in the AKAP6 gene in human populations and explored their association with neurological disorders.

Can AKAP6 be targeted for therapeutic intervention? 06/30/2018

It is possible that AKAP6 could be targeted for therapeutic intervention in the future. As AKAP6 plays a crucial role in regulating synaptic plasticity and neuronal function, modulating its activity or expression may have therapeutic implications for neurological disorders. For example, if AKAP6 is found to be overactive in conditions like schizophrenia, drugs that selectively inhibit AKAP6 function could potentially restore normal synaptic function and alleviate symptoms. However, further research is needed to fully understand the function of AKAP6 in different disorders and to develop safe and effective therapeutic strategies.

Are there any known inhibitors or activators of AKAP6? 06/16/2017

Currently, there are no specific inhibitors or activators of AKAP6 that have been developed for therapeutic use. The modulation of AKAP6 function is mostly studied through genetic or biochemical approaches.

Are there any ongoing clinical trials targeting AKAP6? 02/11/2017

As of now, there are no known ongoing clinical trials specifically targeting AKAP6. However, research on AKAP6 and its role in neurological disorders is an active area of investigation, and it is possible that future clinical trials may explore therapeutic interventions that involve AKAP6 modulation.

Have any studies investigated the role of AKAP6 in neurological disorders? 10/30/2016

While the exact role of AKAP6 in neurological disorders is still being elucidated, some studies have investigated its potential involvement in certain conditions. For example, AKAP6 has been implicated in schizophrenia, a complex psychiatric disorder characterized by disturbances in thinking, perception, and emotions. Genetic studies have identified variations in the AKAP6 gene that may increase the risk of developing schizophrenia. Additionally, animal models have shown that alterations in AKAP6 expression can lead to abnormal behaviors and cognitive deficits reminiscent of schizophrenia-like symptoms.

Is AKAP6 involved in other diseases apart from neurological disorders? 10/02/2016

The majority of research on AKAP6 has focused on its role in neurological disorders. However, AKAP6 has also been implicated in other diseases and conditions. For example, it may play a role in cardiac function and arrhythmias, as it interacts with proteins involved in cardiac signaling. Additionally, AKAP6 has been associated with certain cancers, where it may impact cellular proliferation and survival pathways.

Can AKAP6 be targeted for therapeutic interventions in neurological disorders? 04/15/2015

Targeting AKAP6 for therapeutic interventions in neurological disorders is an area of ongoing research. By understanding its roles in synaptic plasticity and neuronal signaling, it may be possible to develop strategies to modulate AKAP6 function and restore normal neuronal function in diseases. However, more research is needed to fully understand the therapeutic potential of targeting AKAP6.

How is AKAP6 implicated in schizophrenia? 02/15/2015

AKAP6 has been found to be dysregulated in post-mortem brains of individuals with schizophrenia. Variations in the AKAP6 gene have also been associated with the risk of developing schizophrenia. The dysregulation of AKAP6 may contribute to abnormal synaptic signaling and plasticity, which are implicated in the pathophysiology of schizophrenia.

Customer Reviews (4)

Write a review
Reviews
02/24/2019

    Their knowledgeable and dedicated team is readily available to address any concerns or challenges I may encounter along the way.

    08/03/2017

      Their expertise not only guarantees prompt problem-solving but also instills a sense of confidence, knowing that I have a reliable resource to rely on.

      11/11/2015

        Its exceptional quality and the manufacturer's unparalleled technical support offer a seamless and transformative solution to any experimental hurdles I may face.

        09/22/2015

          In light of these remarkable qualities, the AKAP6 protein perfectly aligns with my research needs and aspirations.

          Ask a Question for All AKAP6 Products

          Required fields are marked with *

          My Review for All AKAP6 Products

          Required fields are marked with *

          logo

          FOLLOW US

          Terms and Conditions        Privacy Policy

          Copyright © 2024 Creative BioMart. All Rights Reserved.

          Contact Us

          • /

          Stay Updated on the Latest Bioscience Trends