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AKAP9

  • Official Full Name

    A kinase (PRKA) anchor protein (yotiao) 9

  • Overview

    The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternate splicing of this gene results in at least two isoforms that localize to the centrosome and the Golgi apparatus, and interact with numerous signaling proteins from multiple signal transduction pathways. These signaling proteins include type II protein kinase A, serine/threonine kinase protein kinase N, protein phosphatase 1, protein phosphatase 2a, protein kinase C-epsilon and phosphodiesterase 4D3.
  • Synonyms

    AKAP9; A kinase (PRKA) anchor protein (yotiao) 9; A-kinase anchor protein 9; A kinase anchor protein; 350kDa; A kinase anchoring protein 450; AKAP9 BRAF fusion protein; AKAP120 like protein; AKAP350; AKAP450; centrosome and golgi localized protein; CG NAP; HYPERION; KIAA0803; kinase N associated protein; MU RMS 40.16A; PPP1R45; PRKA9; protein kinase A anchoring protein 9; protein phosphatase 1; regulatory subunit 45; YOTIAO; protein yotiao; protein hyperion; AKAP 120-like protein; AKAP9-BRAF fusion protein; kinase N-associated protein; A-kinase anchor protein 350 kDa; A-kinase anchor protein 450 kDa; protein phosphatase 1, regulatory subunit 45; centrosome- and Golgi-localized PKN-associated protein; AKAP-9; CG-NAP; MU-RMS-40.16A;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human AKAP9-26527TH Recombinant Human AKAP9, His-tagged E.coli His
Human AKAP9-405H Recombinant Human AKAP9 Protein, GST-tagged Wheat Germ GST
Chicken AKAP9-7119C Recombinant Chicken AKAP9 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

AKAP9 involved in several pathways and played different roles in them. We selected most pathways AKAP9 participated on our site, such as ARMS-mediated activation, Activation of NMDA receptor upon glutamate binding and postsynaptic events, Anchoring of the basal body to the plasma membrane, which may be useful for your reference. Also, other proteins which involved in the same pathway with AKAP9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ARMS-mediated activationNRG4;FGFR1B;NTF7;PSME3;KLB;CNKSR1;RASGRP1;FGF10B;SPRED2
Activation of NMDA receptor upon glutamate binding and postsynaptic eventsADCY3;NEFLB;CREB1;PDPK1A;ADCY8;SLC14A2;DLG4;CREB1B;AKAP9
Anchoring of the basal body to the plasma membraneACTR1A;CSNK1E;DCTN1A;CEP152;TMEM67;CLASP1A;CEP57;PCM1;FBF1
Assembly of the primary ciliumCEP290;CCT3;CP110;B9D2;KIF3C;DYNLL2B;DYNC1I2;CCT4;ARF4
Axon guidanceEPHA4;COL6A2;PAK3;SIAH2;ROBO3;CSNK2A1;LAMTOR2;FRS2A;RAC3
CREB phosphorylation through the activation of CaMKIINEFLB;DLG4;CREB1B;AKAP9;NETO2;SLC14A2
CREB phosphorylation through the activation of RasNEFLB;DLG4;SLC14A2;PDPK1A;AKAP9
Cell CycleORC4;CHEK1;ESPL1;BRCC3;GADD45A;RAD9A;STAG2;RNF168;NUP35

AKAP9 has several biochemical functions, for example, ion channel binding, potassium channel regulator activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AKAP9 itself. We selected most functions AKAP9 had, and list some proteins which have the same functions with AKAP9. You can find most of the proteins on our site.

Function Related Protein
ion channel bindingABCC9;RYR2;TRAPPC2;PKD2;PACS1;FKBP1B;CALM;KCNH5;CALM3
potassium channel regulator activityANK2;KCNE1;KCNMB4;KCNIP3;KCNIP2;PRKCZ;KCNMB3;DRD4;KCNIP4
protein bindingSQSTM1;CEP57;SOX30;ZBTB26;KATNBL1;RFX5;ITGB3;PLK3;SIT1
protein complex scaffoldKLHL17;HOMER1;AKAP1;SLC9A3R2;WWC3;MAP2K2;CAV1;SMARCD1;GNB2L1
protein kinase A regulatory subunit bindingACBD3;PJA2;AKAP9;EZR;RYR2;AKAP7;ARFGEF2;C2orf88;AKAP5
receptor bindingHAMP;CX3CL1;CRTAM;PCSK1N;APOF;TRIM24;MATK;LTA;LAMA1

AKAP9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AKAP9 here. Most of them are supplied by our site. Hope this information will be useful for your research of AKAP9.

GOLGA2; KDM1A; p29991-pro_0000037946; ORF; PSTPIP1; ELF3; SMYD2; ACTR3B; PUF60; TULP3; TDP2; C1orf94; pbuO; q81mm5_bacan; ybgA

  • Q&As
  • Reviews

Q&As (17)

Ask a question
What are the known functions of AKAP9 in the heart? 05/03/2023

AKAP9 plays essential roles in cardiac development and function. It is involved in the assembly and organization of the contractile machinery in cardiomyocytes, regulation of calcium signaling, modulation of cardiac gene expression, and maintenance of proper cardiac structure. Mutations in AKAP9 have been associated with dilated cardiomyopathy and other heart-related disorders.

Does AKAP9 have any role in neurodevelopment? 04/01/2023

Yes, AKAP9 has been implicated in neurodevelopment and neuronal function. It is expressed in the developing brain and is involved in neuronal migration, axon guidance, and synapse formation. Mutations in AKAP9 have been linked to intellectual disability and neurodevelopmental disorders.

Does AKAP9 protein have any role in cell motility? 03/02/2023

Yes, AKAP9 has been implicated in cell motility and migration. It interacts with components of the cytoskeleton, such as microtubules and myosin, to regulate cell shape, adhesion, and movement. The precise mechanisms through which AKAP9 modulates cell motility are still being investigated.

Are there any diseases associated with AKAP9 protein mutations? 01/13/2022

Mutations in the AKAP9 gene have been linked to various genetic disorders, such as long QT syndrome, dilated cardiomyopathy, intellectual disability, and other developmental and neurological conditions.

How is the expression of AKAP9 regulated? 12/12/2021

The expression of AKAP9 can be regulated at the transcriptional level by various factors, including transcription factors, epigenetic modifications, and signaling pathways. Additionally, post-translational modifications, such as phosphorylation, can also modulate the activity and localization of AKAP9 protein.

Is AKAP9 protein involved in cancer? 12/05/2021

AKAP9 protein has been implicated in certain types of cancer. For example, alterations in AKAP9 expression have been observed in ovarian, colorectal, and breast cancer, suggesting its potential involvement in tumorigenesis. However, more research is needed to fully understand its role in cancer development and progression.

Can AKAP9 be used as a therapeutic target for cardiovascular diseases? 05/05/2021

Given its involvement in cardiac function and disease, AKAP9 is a potential therapeutic target for cardiovascular disorders. However, developing specific interventions that can effectively modulate AKAP9 activity or interactions while maintaining overall cellular homeostasis remains a significant challenge and requires further research.

Are there any drugs or compounds that target AKAP9? 12/07/2020

Currently, there are no known drugs or compounds specifically targeting AKAP9. However, research efforts are ongoing to identify small molecules or peptides that can selectively modulate the activity or interactions of AKAP9 for potential therapeutic applications.

What are the known functional domains of AKAP9 protein? 07/11/2020

AKAP9 protein contains several functional domains, including spectrin repeats, ankyrin repeats, and a kinase-binding domain (KBD). These domains enable AKAP9 to interact with different signaling molecules and facilitate its diverse functions.

Can AKAP9 protein be used as a biomarker? 04/07/2020

AKAP9 has been proposed as a potential biomarker in certain diseases, such as heart failure. Increased AKAP9 expression has been associated with poor prognosis in heart failure patients. However, further studies are needed to validate its potential as a biomarker in different clinical settings.

What are the known interactions of AKAP9 protein? 01/31/2020

AKAP9 protein interacts with numerous proteins, including protein kinase A (PKA), protein kinase C (PKC), protein phosphatase 2B (PP2B), microtubules, myosin, and various transcription factors.

Are there any animal models for studying AKAP9-related diseases? 12/10/2019

Yes, animal models, such as mice, have been used to study the impact of AKAP9 mutations or knockout on disease phenotypes. These models can help researchers understand the underlying mechanisms, evaluate therapeutic interventions, and assess the consequences of AKAP9 dysfunction in vivo.

How is AKAP9 protein being studied in the context of cancer research? 01/30/2017

AKAP9 is being investigated in cancer research to understand its potential roles in tumorigenesis, metastasis, and response to therapy. Alterations in AKAP9 expression and function have been associated with various cancers, and further studies aim to elucidate the underlying mechanisms and explore its therapeutic implications in cancer treatment.

Can AKAP9 mutations result in embryonic lethality? 01/06/2017

Yes, studies have reported that certain AKAP9 mutations can lead to embryonic lethality in animal models. These mutations can disrupt critical developmental processes, such as heart development or neuronal migration, resulting in severe developmental defects and embryo death.

Can AKAP9 be targeted for therapeutic purposes? 11/19/2016

Due to its crucial role in cellular signaling and its association with certain diseases, AKAP9 has the potential to be a therapeutic target. However, specific drugs or interventions targeting AKAP9 have not yet been developed, and further research is needed to explore this possibility.

How can studying AKAP9 protein contribute to understanding cellular signaling? 09/03/2016

Studying AKAP9 protein can provide insights into the spatial and temporal organization of cellular signaling networks. AKAP9 acts as a scaffold protein, bringing together different signaling molecules and enzymes to facilitate their interactions and regulate downstream signaling events. Understanding the specific interactions and functions of AKAP9 can contribute to elucidating the complexity and dynamics of cellular signaling pathways.

What are the physiological roles of AKAP9 protein? 06/09/2016

AKAP9 is involved in multiple cellular processes, including regulation of cell division and mitotic spindle assembly, cell migration and adhesion, calcium signaling, cAMP-PKA signaling, and gene transcription.

Customer Reviews (4)

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Reviews
07/19/2020

    The AKAP9 protein demonstrates an exceptional level of quality that surpasses expectations, making it the perfect fit for my experimental requirements.

    07/31/2018

      With their unwavering guidance and expertise, I am assured that I will receive the necessary support to overcome any hurdles, enabling seamless progress in my research.

      04/13/2018

        The AKAP9 protein's remarkable attributes ensure that it will not only meet but exceed my experimental needs.

        03/16/2018

          With its superior purity and consistent performance, this protein guarantees reliable and accurate results, aligning impeccably with my research objectives.

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