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AKTIP

  • Official Full Name

    AKT interacting protein

  • Overview

    The mouse homolog of this gene produces fused toes and thymic hyperplasia in heterozygous mutant animals while homozygous mutants die in early development. This gene may play a role in apoptosis as these morphological abnormalities are caused by altered patterns of programmed cell death. The protein encoded by this gene is similar to the ubiquitin ligase domain of other ubiquitin-conjugating enzymes but lacks the conserved cysteine residue that enables those enzymes to conjugate ubiquitin to the target protein. This protein interacts directly with serine/threonine kinase protein kinase B (PKB)/Akt and modulates PKB activity by enhancing the phosphorylation of PKBs regulatory sites. Alternative splicing results in two transcript variants encoding the same protein.
  • Synonyms

    AKTIP; AKT interacting protein; FTS, fused toes (mouse) homolog , fused toes homolog (mouse); AKT-interacting protein; FLJ13258; AKTIP_HUMAN; FT 1; FT1; Fused toes homolog; Fused toes protein homolog; OTTHUMP00000164256; FTS;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • SUMO
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human AKTIP-9543H Recombinant Human AKTIP, His-tagged E.coli His 1-292a.a.
Human AKTIP-8926HCL Recombinant Human AKTIP 293 Cell Lysate HEK293 N/A
Human AKTIP-4535H Recombinant Human AKTIP Protein, GST-tagged Wheat Germ GST
Human AKTIP-4783H Recombinant Human AKTIP protein, His-SUMO-tagged E.coli His-SUMO 1-292aa
Human AKTIP-5125HF Recombinant Full Length Human AKTIP Protein, GST-tagged In Vitro Cell Free System GST 292 amino acids
Mouse AKTIP-1511M Recombinant Mouse AKTIP Protein Mammalian Cell His
Mouse Aktip-1587M Recombinant Mouse Aktip Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse AKTIP-445M-B Recombinant Mouse AKTIP Protein Pre-coupled Magnetic Beads HEK293
Mouse AKTIP-445M Recombinant Mouse AKTIP Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat AKTIP-608R Recombinant Rat AKTIP Protein Mammalian Cell His
Rat AKTIP-264R Recombinant Rat AKTIP Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat AKTIP-264R-B Recombinant Rat AKTIP Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey AKTIP-291C Recombinant Cynomolgus AKTIP Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey AKTIP-41C-B Recombinant Cynomolgus Monkey AKTIP Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey AKTIP-41C Recombinant Cynomolgus Monkey AKTIP Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish AKTIP-10457Z Recombinant Zebrafish AKTIP Mammalian Cell His
Chicken AKTIP-1273C Recombinant Chicken AKTIP Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • AKTIP Related Articles

AKTIP involved in several pathways and played different roles in them. We selected most pathways AKTIP participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with AKTIP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

AKTIP has several biochemical functions, for example, protein binding, ubiquitin protein ligase activity, ubiquitin protein ligase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AKTIP itself. We selected most functions AKTIP had, and list some proteins which have the same functions with AKTIP. You can find most of the proteins on our site.

Function Related Protein
protein bindingATG101;RIC8A;LPP;WWTR1;SGK1;IVL;POP5;XPO5;SART1
ubiquitin protein ligase activityFANCF;RABGEF1;RNF19B;C18orf25;PARK2;UBR1;RNF220;ASB4;MED10
ubiquitin protein ligase bindingYWHAE;RELA;PRR5L;RALB;Fzd4;RB1;TUBA1B;SNX9;BAG4
NOT ubiquitin-like protein transferase activity

AKTIP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AKTIP here. Most of them are supplied by our site. Hope this information will be useful for your research of AKTIP.

HOOK1; HOOK2; 4504555; HDLBP; DCTN1; PDS5A; TIMM50; RASGRF2; MAP3K7; ASS1; NEB; RPA1; ACTN2; TRIM23

Lv, SZ; Dai, CX; et al. Cell Surface Protein C23 Affects EGF-EGFR Induced Activation of ERK and PI3K-AKT Pathways. JOURNAL OF MOLECULAR NEUROSCIENCE 55:519-524(2015).
Chaudhary, P; Thamake, SI; et al. Inhibition of triple-negative and Herceptin-resistant breast cancer cell proliferation and migration by Annexin A2 antibodies. BRITISH JOURNAL OF CANCER 111:2328-2341(2014).
  • Q&As
  • Reviews

Q&As (12)

Ask a question
What are the structural features of AKTIP protein? 05/28/2022

The structural features of AKTIP protein have not been extensively characterized. AKTIP contains multiple domains, including an N-terminal pleckstrin homology (PH) domain and a C-terminal coiled-coil domain. The PH domain is known to interact with phospholipids, suggesting a potential role for AKTIP in membrane association. The coiled-coil domain may be involved in protein-protein interactions and the formation of protein complexes.

Are there any known genetic variations or mutations in the AKTIP gene? 09/30/2020

Information on genetic variations or mutations in the AKTIP gene is limited. However, genetic variations in AKTIP could potentially exist and contribute to the development of specific diseases. Further research and genetic studies are necessary to investigate potential genetic variations or mutations in the AKTIP gene and their associations with diseases or phenotypic traits.

Are there any inhibitors or activators known for AKTIP protein? 12/18/2019

Currently, there have been no specific inhibitors or activators developed for AKTIP protein. However, targeting AKT, the protein that interacts with AKTIP, has been the focus of drug development in various diseases. Small molecule inhibitors of AKT kinase activity, such as MK-2206 and AZD5363, have been developed and are being evaluated in clinical trials. It's possible that targeting AKT could indirectly affect AKTIP function, but direct modulation of AKTIP itself will require further research and development.

What are the potential therapeutic implications of targeting AKTIP protein? 12/07/2019

Targeting AKTIP protein or its interaction with AKT could have therapeutic implications in diseases where dysregulation of AKT signaling is involved. Modulating AKTIP's function could potentially impact AKT activity and cellular processes regulated by AKT, such as cell growth, survival, and metabolism. However, further research is needed to fully understand the therapeutic potential and feasibility of targeting AKTIP for intervention or drug development.

Is AKTIP involved in any signaling pathways other than AKT? 11/02/2019

AKTIP primarily interacts with and regulates AKT signaling. However, some studies suggest that AKTIP may also interact with other signaling molecules and pathways. For instance, AKTIP has been found to interact with phosphoinositide 3-kinase (PI3K) and contribute to PI3K-dependent signaling. Additionally, AKTIP has been reported to interact with Src kinase and play a role in Src-mediated signaling. Further investigation is needed to determine the extent of AKTIP's involvement in other signaling pathways.

Is AKTIP protein expressed in all tissues? 05/26/2019

The expression of AKTIP protein is not well-documented in all tissues. However, studies have reported its expression in various tissues, including the heart, brain, liver, kidney, muscle, and immune cells. Different tissues may have different expression levels of AKTIP, and its expression may be regulated in a tissue-specific manner.

What are the known interactions of AKTIP protein? 05/11/2019

AKTIP interacts with several proteins involved in AKT signaling and other cellular processes. Some of the known interactions include binding to AKT isoforms (AKT1, AKT2, AKT3) and modulating their activity and localization. AKTIP also interacts with other signaling molecules such as PI3K (phosphoinositide 3-kinase) and PHLPP (PH domain and leucine-rich repeat protein phosphatase), which regulate AKT activity.

Is there any disease association linked to AKTIP protein? 03/24/2019

There is limited available information on disease associations specifically linked to AKTIP protein. However, dysregulation of AKT signaling has been implicated in various diseases, such as cancer, diabetes, and neurodegenerative disorders. Since AKTIP is involved in the regulation of AKT signaling, further research is needed to explore if any abnormalities or mutations in AKTIP are associated with specific diseases.

Are there any known post-translational modifications of AKTIP protein? 09/22/2018

Current knowledge about post-translational modifications of AKTIP protein is limited. However, like many other proteins, it is possible that AKTIP undergoes post-translational modifications such as phosphorylation, acetylation, ubiquitination, or methylation. These modifications can potentially regulate AKTIP's function and interaction with other proteins, but further research is needed to fully understand the post-translational modifications of AKTIP.

Have there been any studies on the regulation of AKTIP expression? 03/22/2018

Limited studies have investigated the regulation of AKTIP expression. One study found that the transcription factor EGR1 can bind to the promoter region of AKTIP and regulate its expression in certain cancer cells. Another study suggested a role for the microRNA miR-29a in downregulating AKTIP expression in ovarian cancer cells. More research is necessary to fully understand the mechanisms and factors involved in the regulation of AKTIP expression.

Are there any known diseases or disorders associated with AKTIP protein? 12/19/2017

Currently, there are no specific diseases or disorders that have been directly linked to AKTIP protein. However, dysregulation of AKT signaling has been implicated in various diseases, including cancer, cardiovascular diseases, neurodegenerative diseases, and metabolic disorders. Since AKTIP interacts with AKT and regulates its activity, it is possible that alterations in AKTIP expression or function could indirectly contribute to the development or progression of these diseases. Further research is needed to explore any potential disease associations with AKTIP.

Are there any known functional roles of AKTIP protein beyond AKT signaling? 02/09/2017

The primary known functional role of AKTIP protein is its interaction with and regulation of AKT signaling. However, there is evidence suggesting that AKTIP might have additional functional roles. For example, studies have shown that AKTIP is involved in the regulation of cell migration, invasion, and apoptosis. Further research is needed to elucidate the precise mechanisms and additional functional roles of AKTIP.

Customer Reviews (4)

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Reviews
02/07/2021

    The AKTIP protein stands as a remarkable solution that exemplifies exceptional quality and meets all my experimental requirements.

    06/02/2020

      I am confident that the AKTIP protein will unlock vital insights into cellular processes, propelling my scientific investigations to new heights.

      07/31/2016

        Its impressive purity and functional characteristics make it an ideal choice for my research endeavors, ensuring reliable and impactful results.

        05/25/2016

          An additional advantage of selecting the AKTIP protein is the outstanding technical support offered by its manufacturer.

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