aktip
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  • Official Full Name
  • AKT interacting protein
  • Background
  • The mouse homolog of this gene produces fused toes and thymic hyperplasia in heterozygous mutant animals while homozygous mutants die in early development. This gene may play a role in apoptosis as these morphological abnormalities are caused by altered patterns of programmed cell death. The protein encoded by this gene is similar to the ubiquitin ligase domain of other ubiquitin-conjugating enzymes but lacks the conserved cysteine residue that enables those enzymes to conjugate ubiquitin to the target protein. This protein interacts directly with serine/threonine kinase protein kinase B (PKB)/Akt and modulates PKB activity by enhancing the phosphorylation of PKBs regulatory sites. Alternative splicing results in two transcript variants encoding the same protein.
  • Synonyms
  • AKTIP; AKT interacting protein; FTS, fused toes (mouse) homolog , fused toes homolog (mouse); AKT-interacting protein; FLJ13258; AKTIP_HUMAN; FT 1; FT1; Fused toes homolog; Fused toes protein homolog; OTTHUMP00000164256; FTS
Cat.#:AKTIP-4535HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human AKTIP Protein, GST-tagged
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Cat.#:AKTIP-9543HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AKTIP, His-tagged
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Cat.#:AKTIP-1511MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse AKTIP Protein
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Cat.#:AKTIP-608RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat AKTIP Protein
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Cat.#:AKTIP-291CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus AKTIP Protein, His-tagged
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Cat.#:AKTIP-1273CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken AKTIP
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Cat.#:AKTIP-10457ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish AKTIP
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Cat.#:AKTIP-8926HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human AKTIP 293 Cell Lysate
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Protein Function

AKTIP has several biochemical functions, for example, protein binding, ubiquitin protein ligase activity, ubiquitin protein ligase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AKTIP itself. We selected most functions AKTIP had, and list some proteins which have the same functions with AKTIP. You can find most of the proteins on our site.
Function
Related Protein
Function protein binding
Related Protein HP1BP3; LCE3C; CAPG; CUL2; ZBTB43; MMP9; TMEM19; GLS2; NRBF2; ERG
Function ubiquitin protein ligase activity
Related Protein UBE2G1; CBLC; CMTM2A; UBE2G2; ZNRF2; UBE2C; RNF25; UBE3C; UBR2; UBE3A
Function ubiquitin protein ligase binding
Related Protein STUB1; BLZF1; HIF1A; NPLOC4; MDM2; SLC25A5; DAXX; SKI; SNX9; FOXO1
Function NOT ubiquitin-like protein transferase activity
Related Protein AKTIP

Interacting Protein

AKTIP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AKTIP here. Most of them are supplied by our site. Hope this information will be useful for your research of AKTIP.
HOOK1; HOOK2; 4504555; HDLBP; DCTN1; PDS5A; TIMM50; RASGRF2; MAP3K7; ASS1; NEB; RPA1; ACTN2; TRIM23

AKTIP Related Articles

Lv, SZ; Dai, CX; et al. Cell Surface Protein C23 Affects EGF-EGFR Induced Activation of ERK and PI3K-AKT Pathways. JOURNAL OF MOLECULAR NEUROSCIENCE 55:519-524(2015).
Chaudhary, P; Thamake, SI; et al. Inhibition of triple-negative and Herceptin-resistant breast cancer cell proliferation and migration by Annexin A2 antibodies. BRITISH JOURNAL OF CANCER 111:2328-2341(2014).