aldh7a1
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  • Official Full Name
  • aldehyde dehydrogenase 7 family, member A1
  • Background
  • The protein encoded by this gene is a member of subfamily 7 in the aldehyde dehydrogenase gene family. These enzymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. This particular member has homology to a previously described protein from the green garden pea, the 26g pea turgor protein. It is also involved in lysine catabolism that is known to occur in the mitochondrial matrix. Recent reports show that this protein is found both in the cytosol and the mitochondria, and the two forms likely arise from the use of alternative translation initiation sites. An additional variant encoding a different isoform has also been found for this gene. Mutations in this gene are associated with pyridoxine-dependent epilepsy. Several related pseudogenes have also been identified.
  • Synonyms
  • ALDH7A1; aldehyde dehydrogenase 7 family, member A1; ATQ1; alpha-aminoadipic semialdehyde dehydrogenase; 26g turgor protein homolog; alpha AASA dehydrogenase; alpha aminoadipic semialdehyde dehydrogenase; antiquitin 1; delta1 piperideine 6 carboxylate dehydrogenease; EPD; P6c dehydrogenase; PDE; Aldehyde dehydrogenase 7 A1; Antiquitin; antiquitin-1; OTTHUMP00000159189; OTTHUMP00000242046; alpha-AASA dehydrogenase; betaine aldehyde dehydrogenase; delta1-piperideine-6-carboxylate dehydrogenase
Cat.#:ALDH7A1-452HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ALDH7A1 Protein, GST-tagged
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Cat.#:ALDH7A1-868HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ALDH7A1, His tagged
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Cat.#:Aldh7a1-1358MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Aldh7a1 protein, His-tagged
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Cat.#:ALDH7A1-1533MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ALDH7A1 Protein
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Cat.#:Aldh7a1-1359RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Aldh7a1 protein, His-tagged
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Cat.#:ALDH7A1-623RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat ALDH7A1 Protein
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Cat.#:ALDH7A1-11996ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish ALDH7A1
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Cat.#:ALDH7A1-8915HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human ALDH7A1 293 Cell Lysate
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Involved Pathway

ALDH7A1 involved in several pathways and played different roles in them. We selected most pathways ALDH7A1 participated on our site, such as Glycolysis / Gluconeogenesis, Ascorbate and aldarate metabolism, Fatty acid degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALDH7A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Glycolysis / Gluconeogenesis
ENO1; ALDH2; PGM1; FBP1; LDHC; ACSS2; G6PC; AKR1A1A; ACSS2L; PDHA1
Ascorbate and aldarate metabolism
UGT1A9; UGT2A3; ALDH2.2; UGT1A6A; MIOX; UGT1AB; UGT2A1; ALDH2.1; UGT5G1; UGT1A4
Fatty acid degradation
ADH2-1; ADH1C; ALDH3A2A; HADHAA; ACADL; ACSL1A; ACSBG1; ALDH9A1B; ACSL1; CYP4A11
Glycine, serine and threonine metabolism
SHMT1; TDH; GCAT; SRR; BHMT; AGXT; AGXT2; DAO1; MAOB; PGAM1B
Valine, leucine and isoleucine degradation
OXCT2A; HMGCS2; PCCA; HIBADHB; BCAT2; ACAT2; BCKDHB; HSD17B10; ACAA1A; PCCB
Lysine biosynthesis
ALDH7A1; AADAT
Lysine degradation
SETD8A; EHMT1A; SUV39H2; NSD1; ALDH2; ALDH7A1; ALDH3A2A; CAMKMT; AGPHD1; SETD2
Arginine and proline metabolism
AGMAT; ALDH9A1B; ALDH9A1; SAT2; ALDH2; P4HA1; NOS1; P4HA3; AOC1; DHDPSL
Histidine metabolism
ALDH1B1; ABP1; ALDH7A1; CNDP2; HNMT; ALDH1A3; ALDH3A2; FTCD; AOC1; ALDH3A2A
Tryptophan metabolism
TDO2; ALDH9A1; AANAT2; TDO2A; CMTM2A; ALDH9A1B; HAAO; ALDH7A1; OGDHL; TPH1
beta-Alanine metabolism
CNDP2; DPYDB; AOC3; ACADM; ALDH2; ALDH7A1; ALDH2.2; SMOX; HADHA; ALDH9A1B
Glycerolipid metabolism
LPIN2; GLYCTK; DGKAA; PNPLA2; GPAM; DGAT1A; AKR1B1; STIL; PNLIPRP3; glpK
Pyruvate metabolism
LDHBA; SLC16A8; HAGHL; PCK2; LDHD; ACYP1; LDHAL6B; GRHPR; hchA; ALDH3A2A
Metabolic pathways
POLR2F; POLR2H; LYCAT; GALNT3; PGLS; POLR3H; HPRT1; GATC; AFMID; AMPD3B
Biosynthesis of amino acids
PKLR; ENO1A; CS; ENO3; BCAT1; PYCRL; TPI1B; PRPS1L1; TAT; TKT

Protein Function

ALDH7A1 has several biochemical functions, for example, L-aminoadipate-semialdehyde dehydrogenase activity, aldehyde dehydrogenase (NAD) activity, betaine-aldehyde dehydrogenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ALDH7A1 itself. We selected most functions ALDH7A1 had, and list some proteins which have the same functions with ALDH7A1. You can find most of the proteins on our site.
Function
Related Protein
Function L-aminoadipate-semialdehyde dehydrogenase activity
Related Protein ALDH7A1
Function aldehyde dehydrogenase (NAD) activity
Related Protein ALDH8A1; ALDH9A1A.1; ALDH5A1; ALDH4A1; ALDH3A2A; ALDH1B1; ALDH3B2; ALDH3A1; ALDH9A1; ALDH2
Function betaine-aldehyde dehydrogenase activity
Related Protein ALDH7A1
Function protein binding
Related Protein ICAM3; RGP1; ATP4B; CHTOP; VEPH1; HIP1; RLTPR; CUL4A; TRIM40; RALGAPA1

Interacting Protein

ALDH7A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALDH7A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ALDH7A1.
EPS8; DDA1; UBA5; RECQL5; Rc3h2; Rc3h1