ALDH9A1 Protein, aldehyde dehydrogenase 9 family, member A1


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Official Full Name aldehyde dehydrogenase 9 family, member A1
Background This protein belongs to the aldehyde dehydrogenase family of proteins. It has a high activity for oxidation of gamma-aminobutyraldehyde and other amino aldehydes. The enzyme catalyzes the dehydrogenation of gamma-aminobutyraldehyde to gamma-aminobutyric acid (GABA). This isozyme is a tetramer of identical 54-kD subunits.
Synonyms ALDH9A1; aldehyde dehydrogenase 9 family, member A1; ALDH4, ALDH7, ALDH9; 4-trimethylaminobutyraldehyde dehydrogenase; E3; 4 trimethylaminobutyraldehyde dehydrogenase; AL9A1_HUMAN; aldehyde dehydrogenase (NAD+); Aldehyde dehydrogenase 9A1; Aldehyde dehydrogenase E3 isozyme; Aldehyde dehydrogenase family 9 member A1; ALDH4; ALDH7; ALDH9; Gamma aminobutyraldehyde dehydrogenase; Gamma-aminobutyraldehyde dehydrogenase; R aminobutyraldehyde dehydrogenase; R-aminobutyraldehyde dehydrogenase; TMABADH; OTTHUMP00000032604
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ALDH9A1-454H Recombinant Human ALDH9A1 Protein, GST-tagged Wheat Germ GST
    Human ALDH9A1-61HCL Recombinant Human ALDH9A1 cell lysate N/A
    Mouse Aldh9a1-1360M Recombinant Mouse Aldh9a1 protein, His & T7-tagged E.coli His/T7
    Rat ALDH9A1-624R Recombinant Rat ALDH9A1 Protein Mammalian Cell His

    ALDH9A1 involved in several pathways and played different roles in them. We selected most pathways ALDH9A1 participated on our site, such as Glycolysis / Gluconeogenesis, Ascorbate and aldarate metabolism, Fatty acid degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALDH9A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Glycolysis / Gluconeogenesis PFKL; PKM; PKMB; G6PCA.2; ENO2; AKR1A1; PFKM; GAPDH; ADH2-2; GPI1
    Ascorbate and aldarate metabolism UGT1A6A; GULO; UGT1A4; UGT2B7; ALDH2.1; UGT1AB; UGT2A2; ALDH9A1B; UGT2A3; UGT5G1
    Fatty acid degradation ADH5; ALDH3A2A; CPT1C; ACADS; ALDH3A2; ADH2-1; ACSL1; CYP4A14; CYP4A11; GCDHA
    Valine, leucine and isoleucine degradation ALDH3A2A; ACADS; ALDH3A2; BCAT2; AOX3; HMGCS1; PCCB; ACADSB; AOX2P; OXCT1A
    Lysine degradation GCDH; SUV420H2; OGDHL; SETDB1; BBOX1; ALDH9A1B; EHMT1A; KMT2E; OGDHA; EHMT2
    Arginine and proline metabolism DAO.2; P4HA3; L3HYPDH; PRODH; P4HA1A; CKB; AGMAT; CKBB; SAT2; ALDH2.1
    Histidine metabolism ASPA; ALDH3A2; ALDH3B1; ALDH9A1; ALDH1A3; ALDH2.1; AMDHD1; ALDH9A1B; FTCD; HAL
    Tryptophan metabolism CCBL1; AANAT; INMT; ALDH2.2; HADHAA; CCBL2; AOX4; OGDH; MAOB; IL4I1
    beta-Alanine metabolism DPYDB; ALDH2.2; ALDH3A1; ALDH2.1; HADHA; CNDP2; CARNS1; SMS; GAD1B; ALDH9A1A.1
    Glycerolipid metabolism GLA; MBOAT2; AKR1B1; LPL; TAE1; AKR1B1L; PPAP2C; AKR1A1B; ALDH3A2; PNPLA2
    Pyruvate metabolism ACACA; SLC16A1; PDPR; LDHAL6A; FH1; PKMA; ALDH1B1; LDHD; PKLR; LDHB
    Metabolic pathways UGT1A4; RGN; GGPS1; Atp5g2; ALPI.1; GPIB; GATC; PTGDSB; SPTLC2; DLAT

    ALDH9A1 has several biochemical functions, for example, 1-pyrroline dehydrogenase activity, 3-chloroallyl aldehyde dehydrogenase activity, 4-trimethylammoniobutyraldehyde dehydrogenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ALDH9A1 itself. We selected most functions ALDH9A1 had, and list some proteins which have the same functions with ALDH9A1. You can find most of the proteins on our site.

    Function Related Protein
    1-pyrroline dehydrogenase activity ALDH9A1
    3-chloroallyl aldehyde dehydrogenase activity ALDH9A1; ALDH3B2; ALDH1A1; ALDH3A2A; ALDH3B1; ALDH3A2; ALDH3A1; ALDH2.1; Aldh1a7; ALDH3A2B
    4-trimethylammoniobutyraldehyde dehydrogenase activity ALDH9A1; ALDH9A1B; ALDH9A1A.1
    aldehyde dehydrogenase (NAD) activity Aldh1a7; ALDH5A1; ALDH8A1; ALDH1L1; ALDH3A2; ALDH1L2; ALDH9A1A.1; ALDH9A1B; ALDH9A1; ALDH16A1
    aminobutyraldehyde dehydrogenase activity ALDH9A1A.1; ALDH9A1B; ALDH9A1

    ALDH9A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALDH9A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ALDH9A1.

    HLA-B; USP46; TNIP3; DDA1; flgH1; GABARAPL1

    Yang, Y; Zhou, W; et al. NEK2 mediates ALDH1A1-dependent drug resistance in multiple myeloma. ONCOTARGET 5:11986-11997(2014).
    Li, XS; Xu, Q; et al. ALDH1A1 overexpression is associated with the progression and prognosis in gastric cancer. BMC CANCER 14:-(2014).

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