ANKRD12
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Official Full Name
ankyrin repeat domain 12
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Overview
This gene encodes a member of the ankyrin repeats-containing cofactor family. These proteins may inhibit the transcriptional activity of nuclear receptors through the recruitment of histone deacetylases. The encoded protein interacts with p160 coactivators and also represses transcription mediated by the coactivator alteration/deficiency in activation 3 (ADA3). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. -
Synonyms
ANKRD12; ankyrin repeat domain 12; ankyrin repeat domain-containing protein 12; FLJ20053; GAC 1; KIAA0874; ankyrin repeat-containing cofactor 2; ANCO1; GAC-1; ANCO-2; Nbla00144;
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Zebrafish | ANKRD12-10497Z | Recombinant Zebrafish ANKRD12 | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
- ANKRD12 Related Articles
ANKRD12 involved in several pathways and played different roles in them. We selected most pathways ANKRD12 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ANKRD12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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ANKRD12 has several biochemical functions, for example, molecular_function. Some of the functions are cooperated with other proteins, some of the functions could acted by ANKRD12 itself. We selected most functions ANKRD12 had, and list some proteins which have the same functions with ANKRD12. You can find most of the proteins on our site.
Function | Related Protein |
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molecular_function | NLRP4B;GM996;CTXN3;FNIP2;IFRD2;MIEF2;ERC1A;PDDC1;SOWAHCB |
ANKRD12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ANKRD12 here. Most of them are supplied by our site. Hope this information will be useful for your research of ANKRD12.
- Q&As
- Reviews
Q&As (22)
Ask a questionThe post-translational modifications of ANKRD12 have not been extensively characterized. Future research may uncover potential modifications such as phosphorylation or acetylation.
Yes, ANKRD12 contains ankyrin repeat domains as well as a LEM domain, which is involved in nuclear membrane association.
There is limited evidence suggesting a potential role for ANKRD12 in neuronal development and function. Further studies are needed to fully understand the involvement of ANKRD12 in these processes.
Currently, there is limited information regarding the involvement of ANKRD12 in cancer development or progression. However, some studies have reported altered expression of ANKRD12 in certain types of cancer, such as hepatocellular carcinoma and colorectal cancer. Further research is needed to fully understand the relationship between ANKRD12 and cancer.
Yes, ANKRD12 has orthologs in various species, including mice, rats, and zebrafish. Paralogs of ANKRD12 within the same genome have not been extensively studied.
KBG syndrome is the primary condition associated with mutations in the ANKRD12 gene. However, additional research is ongoing, and future studies may uncover other diseases or conditions in which ANKRD12 plays a role.
As of now, there are no known therapeutic interventions specifically targeting ANKRD12. However, further research into its functions and potential involvement in diseases may lead to the development of targeted therapies in the future.
Yes, ANKRD12 is highly conserved across diverse species, indicating its functional importance. The conservation suggests potential conserved roles in cellular processes throughout evolution.
Currently, there are no reported animal models specifically generated to study ANKRD12 function. However, the use of knockout or knockdown models for ANKRD12 in various organisms may provide valuable insights into its physiological roles and potential effects on development or disease.
Recent studies suggest that ANKRD12 is not essential for cell viability, but it may play a role in proper development, particularly in certain tissues or organ systems.
Yes, ANKRD12 can undergo post-translational modifications that may influence its function. For instance, phosphorylation of ANKRD12 by kinases such as PKC and CK2 has been reported to regulate its subcellular localization and interaction with other proteins. However, more research is needed to fully understand the extent and functional consequences of post-translational modifications on ANKRD12.
ANKRD12 has been shown to interact with several proteins and participate in various cellular pathways. Some known interacting proteins include HIRA, CHD7, SET, p300, and RuvBL2. Additionally, ANKRD12 has been implicated in pathways related to chromatin remodeling, cellular senescence, and DNA replication.
es, mutations in the ANKRD12 gene have been associated with a rare genetic disorder called KBG syndrome. Symptoms of KBG syndrome can vary but often include intellectual disability, short stature, dental abnormalities, and distinctive facial features.
Although ANKRD12 has not been extensively studied in the context of neurodevelopmental disorders, mutations in the ANKRD12 gene have been associated with developmental delay and intellectual disability, suggesting its potential involvement in neurodevelopmental processes.
Currently, there are no known specific inhibitors or activators of ANKRD12. Future research may identify compounds or molecules that modulate its activity.
Current research suggests that ANKRD12 is not directly involved in signal transduction pathways. However, it may have indirect effects on gene expression and cellular processes through its interaction with other proteins.
Yes, ANKRD12 has been shown to interact with transcriptional co-regulatory factors and may participate in the regulation of gene expression. However, the specific mechanisms by which ANKRD12 modulates transcriptional activity require further investigation.
Functional studies of ANKRD12 can be conducted using techniques like gene knockdown or overexpression, protein-protein interaction assays, ChIP-seq, RNA-seq, and immunofluorescence microscopy.
ANKRD12 has been shown to interact with various proteins involved in chromatin remodeling, transcriptional regulation, and nuclear envelope organization. Examples include LEM domain-containing proteins and transcriptional co-regulatory factors.
ANKRD12 has been implicated in diverse molecular functions, such as protein-protein interaction, chromatin remodeling, transcriptional regulation, DNA replication, and nuclear envelope organization.
ANKRD12 is implicated in diverse biological processes, such as chromatin organization, DNA replication, transcriptional regulation, and nuclear envelope assembly.
ANKRD12 has been reported to be expressed during embryonic development in various tissues and organs. Its expression pattern suggests potential roles in processes such as organogenesis and tissue maturation.
Customer Reviews (5)
Write a reviewthe protein's high quality ensures accurate and reliable results, enabling precise analysis and interpretation of experimental data.
The ANKRD12 protein offers several advantageous features that make it an ideal choice for researchers conducting trials.
The manufacturer of the ANKRD12 protein plays a crucial role in supporting researchers during their trials.
the ANKRD12 protein demonstrates exceptional stability, allowing for prolonged storage and usage without compromising its integrity.
By choosing the ANKRD12 protein and partnering with the manufacturer, researchers can confidently conduct their trials, achieve reliable results, and contribute to groundbreaking discoveries.
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