appl1
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  • Official Full Name
  • adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
  • Background
  • APPL1 (adaptor protein containing PH domain, PTB domain and leucine zipper motif 1) mediates adiponectin signaling in various types of cells. APPL1 is also thought to have a role in insulin signaling.
  • Synonyms
  • APPL1; adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1; DCC-interacting protein 13-alpha; APPL; dip13-alpha; AKT2 interactor; signaling adaptor protein DIP13alpha; adapter protein containing PH domain, PTB domain an
Cat.#:APPL1-16HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human APPL1 Protein, MYC/DDK-tagged
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Cat.#:APPL1-7563HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human APPL1 Protein, His-tagged
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Cat.#:APPL1-26345THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human APPL1, His-tagged
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Cat.#:APPL1-725HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human APPL1 protein, GST-tagged
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Cat.#:APPL1-9774HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human APPL1, GST-tagged
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Cat.#:APPL-724HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human APPL protein, GST-tagged
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Cat.#:APPL1-1814MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse APPL1 Protein
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Cat.#:APPL1-6802ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish APPL1
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Cat.#:APPL1-1001HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human APPL1, His-tagged
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Cat.#:APPL1-8772HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human APPL1 293 Cell Lysate
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Involved Pathway

APPL1 involved in several pathways and played different roles in them. We selected most pathways APPL1 participated on our site, such as Pathways in cancer, Colorectal cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with APPL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Pathways in cancer
ITGAV; F2RL3; AXIN2; WNT8B; RUNX1; RASGRP3; CCDC6; CUL2; MSH6; MITF
Colorectal cancer
RAC2; BIRC5; MAPK3; PIK3R2; KRAS; PIK3R1; MAPK10; TCF7L2; PIK3R3; RHOA

Protein Function

APPL1 has several biochemical functions, for example, identical protein binding, protein binding, protein kinase B binding. Some of the functions are cooperated with other proteins, some of the functions could acted by APPL1 itself. We selected most functions APPL1 had, and list some proteins which have the same functions with APPL1. You can find most of the proteins on our site.
Function
Related Protein
Function identical protein binding
Related Protein ATXN10; MLL1; MCM10; SDF4; ESYT2; APP; TTR; KCNJ10; NQO1; ITGB3
Function protein binding
Related Protein RBM12B; ARHGEF4; PRPF40A; ZMAT3; IL28RA; FGF2; ANGPTL4; STAM2; POLE3; CCDC110
Function protein kinase B binding
Related Protein APPL1; CDC37; TRAF6; PDE3B; PINK1; CCDC88A; RARA; ANKRD2; BCL10; BAD

Interacting Protein

APPL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APPL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of APPL1.
APPL2; RAB5A