APPL1
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Official Full Name
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
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Overview
APPL1 (adaptor protein containing PH domain, PTB domain and leucine zipper motif 1) mediates adiponectin signaling in various types of cells. APPL1 is also thought to have a role in insulin signaling. -
Synonyms
APPL1; adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1; DCC-interacting protein 13-alpha; APPL; dip13-alpha; AKT2 interactor; signaling adaptor protein DIP13alpha; adapter protein containing PH domain, PTB domain an;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
APPL1 involved in several pathways and played different roles in them. We selected most pathways APPL1 participated on our site, such as Pathways in cancer, Colorectal cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with APPL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Pathways in cancer | GNG10;GNG3;GNB2;LAMC2;GNAS;GNAI1;MAPK1;APPL1;GSTP1 |
Colorectal cancer | BIRC5;MSH6;APPL1;PIK3CD;APC;MAPK10;PIK3CA;TGFB1;RALGDS |
APPL1 has several biochemical functions, for example, identical protein binding, protein binding, protein kinase B binding. Some of the functions are cooperated with other proteins, some of the functions could acted by APPL1 itself. We selected most functions APPL1 had, and list some proteins which have the same functions with APPL1. You can find most of the proteins on our site.
Function | Related Protein |
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identical protein binding | DPP9;CIDEB;LYZ1;GOT1;FHIT;CLDN15;SH2B2;FZD1;PON2 |
protein binding | IP6K2;ICK;SMAD9;MTF1;NPRL2;RRM2B;MAPK3;DNAIC2;SMAD3B |
protein kinase B binding | CDC37;RARA;APPL1;TRAF6;BAD;PINK1;ANKRD2;BCL10;PDE3B |
APPL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APPL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of APPL1.
APPL2; RAB5A
- Q&As
- Reviews
Q&As (20)
Ask a questionYes, animal models, such as mice, have been used to study APPL1's physiological functions. By generating Appl1 knockout mice, researchers have been able to investigate the impact of APPL1 loss on different cellular processes and disease conditions.
There is emerging evidence suggesting a potential link between APPL1 and neurodegenerative disorders such as Alzheimer's disease. APPL1 has been found to interact with key proteins involved in Alzheimer's pathology, including β-amyloid precursor protein (APP) and the amyloid precursor protein intracellular domain (AICD). These interactions may influence APP processing and the formation of amyloid plaques, which are characteristic of Alzheimer's disease. However, further research is needed to fully understand the role of APPL1 in neurodegenerative disorders.
Yes, APPL1 can interact with a variety of proteins to mediate signal transduction. Some of its known interaction partners include proteins involved in insulin signaling, such as IRS1 and IRS2, as well as components of the mTOR pathway, such as TSC2, Rheb, and AMPK. APPL1 also interacts with certain membrane trafficking proteins, including Rab5 and EEA1.
There are currently no drugs specifically targeting APPL1-related pathways that are in clinical use. However, the signaling pathways regulated by APPL1, such as the PI3K/AKT pathway, are actively targeted by various therapeutic agents. For example, PI3K inhibitors and AKT inhibitors are being developed and tested in clinical trials for the treatment of cancer and other diseases. These agents indirectly modulate APPL1-related pathways by targeting key components downstream of APPL1.
APPL1 has been studied as a potential biomarker for certain diseases, although its clinical utility as a diagnostic or prognostic marker is still uncertain. There is evidence to suggest that APPL1 expression levels may be altered in insulin resistance, type 2 diabetes, and some types of cancer. However, more research is needed to validate the use of APPL1 as a biomarker and establish its specificity, sensitivity, and clinical relevance in different disease contexts.
Yes, APPL1 is implicated in regulating cellular metabolism. It is known to modulate insulin signaling, which plays a central role in glucose metabolism. APPL1's interaction with components of the mTOR pathway also suggests its involvement in nutrient sensing and metabolic regulation.
Targeting APPL1 or the signaling pathways in which it is involved could have therapeutic implications. For example, modulating APPL1 interactions or expression levels may help regulate insulin sensitivity or potentially influence cancer progression. However, more research is needed to fully understand and develop specific therapeutic strategies.
Yes, the APPL1 protein can undergo post-translational modifications. For example, it can be phosphorylated on specific residues, which can regulate its interaction with other proteins or modulate its cellular functions. Post-translational modifications of APPL1 may play a role in fine-tuning its activity and mediating its involvement in various cellular processes.
Yes, genetic variations in the APPL1 gene have been identified. Some studies have suggested that certain single nucleotide polymorphisms (SNPs) in APPL1 may be associated with increased risk of insulin resistance, metabolic disorders, and cardiovascular diseases.
Yes, APPL1 has been found to play a role in neuronal functions and neurodegenerative disorders. It is expressed in various regions of the brain and has been associated with neuronal development, synaptic plasticity, and neuroprotection. Its dysregulation has been linked to diseases like Alzheimer's and Parkinson's.
Yes, APPL1 has been linked to cancer development and progression. It can function as a tumor suppressor by inhibiting cell growth and inducing apoptosis in certain cancer types. However, in other contexts, APPL1 can also promote cancer cell survival and invasion.
APPL1 itself is not commonly used as a drug target, as it is an intracellular protein and challenging to directly target with small molecules. However, the signaling pathways and protein interactions regulated by APPL1 may be targeted for therapeutic purposes. For example, inhibiting or activating upstream kinases or downstream effectors of APPL1 could potentially modulate its signaling and cellular functions.
While APPL1 has been implicated in various diseases, it is not commonly used as a diagnostic marker. Further research is needed to determine its specific clinical utility and potential as a diagnostic marker for specific diseases.
APPL1 plays a crucial role in insulin signaling. It interacts with several key proteins in the insulin signaling cascade, such as IRS1 and IRS2, facilitating their activation and downstream signaling. APPL1's interaction with insulin receptors and its localization to the plasma membrane contribute to the regulation of insulin signaling and glucose metabolism.
APPL1 has been shown to have a role in cellular stress responses. It has been reported to modulate AMPK signaling, which is activated during energy stress conditions. APPL1's involvement in autophagy and its interaction with stress-related proteins suggest potential roles in cellular adaptation to stress.
Targeting APPL1 may have therapeutic implications in certain diseases. For example, modulating APPL1 expression or activity could potentially be beneficial in insulin resistance, type 2 diabetes, and obesity by improving insulin signaling and glucose metabolism. Additionally, targeting APPL1-related pathways may be explored in neurodegenerative disorders and cancer. However, more research is needed to better understand the therapeutic potential and safety profile of targeting APPL1 in different disease contexts.
There have been reports of genetic variants and mutations in the APPL1 gene, but their functional implications and associations with diseases are still being investigated. Further research is needed to better understand the genetic variations in APPL1 and their potential impact on cellular functions and disease susceptibility.
Yes, dysregulation of APPL1 expression and function has been implicated in various diseases. For example, APPL1 deficiency or altered expression has been observed in insulin resistance, type 2 diabetes, obesity, cardiovascular diseases, and various cancers.
APPL1 interacts with several components of the insulin signaling pathway, such as insulin receptor substrate proteins (IRS) and AKT, to enhance insulin signaling and downstream metabolic responses.
Yes, APPL1 is involved in intracellular vesicle trafficking processes. It interacts with proteins such as Rab5 and EEA1, which are involved in endocytic trafficking and early endosome function. APPL1's association with these proteins suggests its role in regulating membrane dynamics and vesicle trafficking.
Customer Reviews (4)
Write a reviewAs a researcher utilizing the APPL1 protein in my trials, I have been highly impressed with its numerous advantages that significantly contribute to the success of my experimental endeavors.
Its purity and consistency enable accurate and precise data analysis, ensuring the integrity of my research outcomes.
One of the primary advantages of the APPL1 protein is its versatility in various trial applications.
the APPL1 protein's exceptional quality, reliability, and the manufacturer's unparalleled technical support make it a prime choice for researchers seeking to delve into the intricacies of angiogenesis, vascular development, and related fields.
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