arap1
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  • Official Full Name
  • ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
  • Background
  • The protein encoded by this gene contains SAM, ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology (PH) domains. In vitro, this protein displays RHO-GAP and phosphatidylinositol (3,4,5) trisphosphate (PIP3)-dependent ARF-GAP activity. The encoded protein associates with the Golgi, and the ARF-GAP activity mediates changes in the Golgi and the formation of filopodia. It is thought to regulate the cell-specific trafficking of a receptor protein involved in apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • ARAP1; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1; centaurin, delta 2 , CENTD2; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1; ANK repeat and PH domain-containing protein 1; mKIAA0782; 2410002L19Rik; ARAP 1; ARAP1_HUMAN; Arf GAPRho GAP ankyrin repeat and pleckstrin homology domains containing protein 1; Arf GAP Rho GAP ankyrin repeat and pleckstrin homology domain containing protein 1; Arf-GAP with Rho-GAP domain; CENT D2; Centaurin delta 2; Centaurin delta2; Centaurin-delta-2; CENTD 2; CENTD2; Cnt d2; Cnt-d2; Cntd2; KIAA0782; MGC176140; OTTHUMP00000211458; OTTHUMP00000211459; OTTHUMP00000211460; OTTHUMP00000211461; OTTHUMP00000211462; OTTHUMP00000211463; centaurin, delta 2; ARF-GAP, RHO-GAP, anky
Cat.#:ARAP1-26993THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ARAP1, His-tagged
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Cat.#:ARAP1-32HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ARAP1 protein, GST-tagged
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Cat.#:ARAP1-1832MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ARAP1 Protein
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Cat.#:ARAP1-337HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human ARAP1 cell lysate
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Involved Pathway

ARAP1 involved in several pathways and played different roles in them. We selected most pathways ARAP1 participated on our site, such as Endocytosis, Regulation of RhoA activity, Rho GTPase cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARAP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Endocytosis
ARPC5LA; ADRB2A; SNX6; RNF41; HRAS; RAB7A; WIPF1A; RAB5AA; TFR1A; CAPZA3
Regulation of RhoA activity
PLEKHG6; ARHGEF10; ARHGEF18; ARHGEF15; ARAP1; ARHGAP9; MCF2L; FARP1; ABR; ARHGEF25
Rho GTPase cycle
STARD8; ARHGAP4A; FGD4; ARHGEF18A; GDI2; ARHGAP23; ARHGAP17; GMIP; FGD2; ARHGEF16
Signal Transduction
TLE3B; OXGR1; KREMEN1; RAB6A; WIF1; PENK; ARHGAP28; TNKS; GREM2; RLBP1A
Signaling by Rho GTPases
ARHGAP12; FAM13A; DLC1; ARHGAP1; GDI1; PLEKHG2; DCLRE1B; RHOT1; NOXO1; ARHGAP36

Protein Function

ARAP1 has several biochemical functions, for example, GTPase activator activity, metal ion binding, phosphatidylinositol-3,4,5-trisphosphate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARAP1 itself. We selected most functions ARAP1 had, and list some proteins which have the same functions with ARAP1. You can find most of the proteins on our site.
Function
Related Protein
Function GTPase activator activity
Related Protein ARHGAP35; RANGAP1B; TBC1D20; DLC1; RIC8A; TBC1D19; TBC1D22B; RASAL3; RGS5; RIC8B
Function metal ion binding
Related Protein CYP2K16; TYRP1B; KDM8; ADARB2; CHN1; GNA14; CYP2C70; TROVE2; CCC2; KDM6BB
Function phosphatidylinositol-3,4,5-trisphosphate binding
Related Protein PARD3; ARAP1; AKT1; OGT; FAM21C; GBF1; BTK; CYTH3; INPPL1; ASAP1
Function protein binding
Related Protein HSPA1L; PSMC4; RAB6A; OAZ3; PTPN11A; ZBTB4; TGFB1; TRAF2; IGF2; PDLIM4
Function type 1 angiotensin receptor binding
Related Protein BDKRB2; GNG3; GNA13A; ARAP1; GNA13; TYK2; GNB1; AGT; JAK2; ARRB2

Interacting Protein

ARAP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARAP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARAP1.
TNFRSF10A; XRCC6; p27958-pro_0000037576; TNFRSF10B; ARPC3; ARIH2; FGFR3; TAB1; pi3p; VCAM1; GRB2; SNW1; UBASH3B