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ARHGAP4

  • Official Full Name

    Rho GTPase activating protein 4

  • Overview

    This gene encodes a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins belonging to the RAS superfamily. The protein encoded by the orthologous gene in rat is localized to the Golgi complex and can redistribute to microtubules. The rat protein stimulates the activity of some Rho GTPases in vitro. Genomic deletions of this gene and a neighboring gene have been found in patients with nephrogenic diabetes insipidus. Multiple transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    ARHGAP4; Rho GTPase activating protein 4; rho GTPase-activating protein 4; ARHGAP 4; C1; KIAA0131; OTTHUMP00000026004; p115; RGC 1; RGC1; Rho GAP hematopoietic protein C1; Rho type GTPase activating protein 4; RhoGAP 4; RhoGAP4; OTTHUMP00000026003; OTTHUMP00000063090; OTTHUMP00000196209; OTTHUMP00000198723; Rho-GAP hematopoietic protein C1; rho-type GTPase-activating protein 4; SrGAP4;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ARHGAP4-9827H Recombinant Human ARHGAP4, GST-tagged E.coli GST 714-986a.a.
Human ARHGAP4-770H Recombinant Human ARHGAP4 protein, GST-tagged Wheat Germ GST
Human ARHGAP4-26278TH Recombinant Human ARHGAP4, His-tagged E.coli His
Human ARHGAP4-113HCL Recombinant Human ARHGAP4 cell lysate N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ARHGAP4 Related Articles

ARHGAP4 involved in several pathways and played different roles in them. We selected most pathways ARHGAP4 participated on our site, such as Cell death signalling via NRAGE, NRIF and NADE, G alpha (12/13) signalling events, GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARHGAP4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cell death signalling via NRAGE, NRIF and NADEMCF2L;KALRN;CASP2;ARHGAP4;FGD4;ARHGEF1A;FGD2;ITSN1;ITGB3BP
G alpha (12/13) signalling eventsARHGEF1B;TIAM2;FGD2;KALRNB;ARHGEF17;RHOGA;TRIO;ARHGEF18A;ITSN1
GPCR downstream signalingCALCRL;ARHGEF25;ADRA2A;RHOL;CRHR2;RAMP2;DRD2;DCLRE1B;CHRM5
NRAGE signals death through JNKNET1;ARHGEF18;FGD4A;ARHGEF17;ARHGEF16;TIAM2;ECT2;ARHGAP4;ABR
Regulation of RhoA activityMYO9B;ARHGEF18;ARHGAP9;ARHGEF10L;NET1;FARP1;MCF2L;ARHGEF28;ARHGEF10
Rho GTPase cycleDLC1;TAGAP1;ARHGAP44;RHOF;DEPDC1B;NET1;ARHGAP29;ARHGAP9;ARHGEF16
Signal TransductionIRBP;STRAP;PRLH;HHAT;OPN4B;OPHN1;ARHGAP17B;ABI1B;SHB
Signaling by GPCRGPRC6A;RAMP2;VIP2;OXER1;OR52B4;EDNRAB;NPB;PYY;OPN4A

ARHGAP4 has several biochemical functions, for example, GTPase activator activity, Rac GTPase binding, SH3/SH2 adaptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ARHGAP4 itself. We selected most functions ARHGAP4 had, and list some proteins which have the same functions with ARHGAP4. You can find most of the proteins on our site.

Function Related Protein
GTPase activator activityASAP1;CHN2;TBC1D13;AXIN2;RGS3;FAM13B1;ARHGAP20;ADAP2;RAP1GAP2B
Rac GTPase bindingRALBP1;DOCK7;OCRL;PAK6;ARHGAP4A;FLNA;SRGAP1;ARHGAP4;SRGAP2
SH3/SH2 adaptor activitySTAM;NCK2;SKAP1;SOCS2;SH2B2;SKAP2;GRB7;CHN1;STAP1
protein bindingGCA;FANCB;STAU1;INTS3;NLGN4Y;ARHGAP5;PLAUR;COX17;STAR

ARHGAP4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARHGAP4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARHGAP4.

FASLG; ftsZ; rdgC; 15-deoxy-delta(12,14

Jarius, S; Scharf, M; et al. Antibodies to the inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) in cerebellar ataxia. Journal of Neuroinflammation 11:-(2014).
Abolghait, SK; Iida, T; et al. Recombinant AexU effector protein of Aeromonas veronii bv. sobria disrupts the actin cytoskeleton by downregulation of Rac1 and induces direct cytotoxicity to beta 4-integrin expressing cell lines. MICROBIAL PATHOGENESIS 51:454-465(2011).
  • Q&As
  • Reviews

Q&As (20)

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What are the potential therapeutic implications of targeting ARHGAP4? 03/27/2023

Targeting ARHGAP4 could have therapeutic implications, especially in diseases where Rho GTPase signaling is dysregulated. Modulating ARHGAP4 activity or expression can potentially affect cellular processes such as cancer cell invasion, migration, and neuronal development. Therefore, the development of ARHGAP4-targeted therapies holds promise in certain pathological conditions.

Are there any known downstream targets or effectors of ARHGAP4? 03/11/2023

ARHGAP4 functions as a Rho GTPase activating protein (GAP), primarily targeting members of the Rho family, including RhoA, Rac1, and Cdc42. By catalyzing the hydrolysis of GTP to GDP, ARHGAP4 negatively regulates the activity of these GTPases. This, in turn, can modulate downstream effectors and signaling pathways involved in cytoskeletal dynamics, cell migration, adhesion, and other cellular processes.

Are there any known mutations or genetic variations in ARHGAP4 associated with human diseases? 12/19/2022

While there is limited information available regarding mutations or genetic variations specifically in ARHGAP4, alterations in Rho GTPase signaling pathways have been implicated in various human diseases, including cancer, neurological disorders, and cardiovascular diseases. Dysregulation of ARHGAP4 or its target Rho GTPases may contribute to disease progression, but further studies are needed to determine the specific genetic variations or mutations in ARHGAP4 associated with these conditions.

Are there any specific domains or motifs present in ARHGAP4? 07/26/2022

Yes, ARHGAP4 contains several conserved domains, including a central RhoGAP domain responsible for its GTPase-activating activity. It also possesses a pleckstrin homology (PH) domain and a proline-rich region that may contribute to its protein-protein interactions and regulation.

How is ARHGAP4 regulated at the transcriptional or post-translational level? 02/10/2022

The regulation of ARHGAP4 at the transcriptional or post-translational level is not well understood. It is possible that ARHGAP4 expression may be regulated by various transcription factors or signaling pathways, but specific mechanisms have yet to be identified. Post-translational modifications, such as phosphorylation or ubiquitination, could also potentially regulate ARHGAP4 activity or stability, but further research is needed to elucidate these processes.

Are there any known animal models or knockout studies for ARHGAP4? 12/20/2021

Currently, there are no specific animal models or knockout studies for ARHGAP4 available. Generating animal models or using knockout approaches could provide valuable insights into the physiological functions of ARHGAP4 and its contributions to developmental processes or disease conditions.

Are there any animal models or knockout studies for ARHGAP4? 09/24/2019

Animal models and knockout studies for ARHGAP4 have been utilized to investigate its physiological and pathological roles. Mice with ARHGAP4 gene knockout have been generated, providing valuable insights into its relevance in development and disease. These models contribute to understanding the consequences of ARHGAP4 deficiency and its impact on various biological processes.

Is ARHGAP4 involved in neuronal development or synaptic plasticity? 05/21/2019

Yes, ARHGAP4 has been implicated in neuronal development and synaptic plasticity. Rho GTPases are known to play crucial roles in neuronal processes, including axon guidance, dendritic spine formation, and synaptic plasticity. As an upstream regulator of Rho GTPases, ARHGAP4 can influence these processes, although the specific mechanisms are not fully elucidated.

Can ARHGAP4 interact with other proteins to form complexes or signaling networks? 11/12/2018

Yes, ARHGAP4 can interact with other proteins to form complexes or be part of signaling networks. These interactions help regulate its activity and participate in specific cellular functions. Characterizing these protein-protein interactions is essential to understand the broader functional roles of ARHGAP4.

How does ARHGAP4 regulate Rho GTPases? 09/18/2018

ARHGAP4 acts as a GTPase-activating protein (GAP) for Rho GTPases. It stimulates the hydrolysis of GTP (guanosine triphosphate) to GDP (guanosine diphosphate) on Rho GTPases, consequently inactivating them. This helps regulate the dynamic activities of Rho GTPases and controls cellular processes.

Does ARHGAP4 have any role in cell adhesion or junction dynamics? 09/06/2018

Yes, ARHGAP4 has been implicated in regulating cell adhesion and junction dynamics. Through its modulation of Rho GTPases, ARHGAP4 can participate in the regulation of actin cytoskeleton dynamics, which is involved in cell adhesion and formation of cell-cell junctions. Dysregulation of ARHGAP4 may disrupt these processes and contribute to altered cell adhesion and junction dynamics.

Are there any genetic variations or mutations associated with ARHGAP4? 03/07/2018

Yes, genetic variations and mutations in the ARHGAP4 gene have been reported. Some mutations may lead to altered protein function or expression levels, thereby contributing to the development of certain diseases or disorders.

Are there any known interacting proteins or binding partners of ARHGAP4? 12/11/2017

Several proteins have been identified as interacting partners of ARHGAP4, including members of the Rho GTPase family, such as RhoA and Rac1. ARHGAP4 can also interact with other proteins involved in cytoskeletal regulation, cell adhesion, and signaling pathways, such as p190RhoGAP, p115RhoGEF, and p120-catenin. These interactions suggest that ARHGAP4 can function in complex regulatory networks and participate in multiple cellular processes.

Are there any specific cellular processes associated with ARHGAP4? 12/05/2017

Yes, ARHGAP4 has been implicated in several cellular processes, such as cell migration, cell polarity, and axon guidance. It is also involved in regulating the actin cytoskeleton, which is essential for various cellular functions.

Is there any research on the role of ARHGAP4 in neurodegenerative diseases? 10/19/2017

While the direct involvement of ARHGAP4 in neurodegenerative diseases is not well-established, studies have implicated aberrant Rho GTPase signaling in neurodegenerative processes. Given ARHGAP4's role in regulating Rho GTPases, it is an area of research interest to explore its potential contribution to neurodegeneration and identify any therapeutic opportunities.

Are there any known interacting partners of ARHGAP4? 07/24/2017

Yes, ARHGAP4 interacts with several proteins. For example, it has been shown to interact with the E3 ubiquitin ligase Nedd4-2, which controls the degradation and stability of ARHGAP4. It has also been reported to interact with other Rho GTPases, effector proteins, and scaffold proteins involved in regulating cellular processes.

Are there any known inhibitors or activators of ARHGAP4? 10/20/2016

At present, there are no specific inhibitors or activators identified for ARHGAP4. However, since ARHGAP4 acts as a negative regulator of Rho GTPases, modulating the activity or expression of these GTPases indirectly affects the function of ARHGAP4. Therefore, compounds targeting Rho GTPase signaling pathways could indirectly influence ARHGAP4 activity.

Does ARHGAP4 play a role in immune cell function? 08/07/2016

There is limited information available regarding the role of ARHGAP4 in immune cell function. However, since ARHGAP4 is expressed in immune cells, it is likely to play a role in regulating immune cell processes such as migration, adhesion, and signaling. Further studies are needed to determine the specific contributions of ARHGAP4 to immune cell function and immune-related diseases.

Is ARHGAP4 expressed in all cell types? 05/12/2016

ARHGAP4 is widely expressed in various cell types and tissues throughout the body. Its expression can vary depending on the developmental stage and tissue context.

Can ARHGAP4 be regulated by cellular signals or stimuli? 03/11/2016

Yes, ARHGAP4 can be regulated by various cellular signals and stimuli. For example, growth factors, cytokines, and extracellular matrix components can influence its expression and activity. Additionally, cellular stress, such as oxidative stress or DNA damage, can also affect ARHGAP4 regulation.

Customer Reviews (10)

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Reviews
07/05/2021

    The protein bands detected were exceptionally distinct, enabling easy interpretation and accurate analysis of protein expression patterns.

    06/16/2021

      To summarize, the ARHGAP4 protein is a highly recommended asset for various research endeavors, including ELISA, protein electron microscopy structure analysis, and Western blotting.

      12/26/2020

        This reliable supply chain management assures that I have uninterrupted access to the protein, allowing me to plan and conduct my experiments without concern for availability issues.

        02/14/2019

          With their assistance, I am confident in overcoming challenges, producing robust results, and advancing our understanding of ARHGAP4 protein and its biological significance.

          01/06/2019

            This level of sensitivity and specificity has streamlined my research and allowed for precise protein characterization.

            01/05/2019

              They ensure a reliable and consistent supply of ARHGAP4 protein, minimizing any potential disruptions in my experimental workflow.

              01/28/2018

                Whether it involves experimental design, protocol optimization, or data analysis, their expertise can help me navigate through complexities, saving valuable time and resources.

                01/22/2017

                  They ensure a reliable and consistent supply of ARHGAP4 protein, minimizing any potential disruptions in my experimental workflow.

                  05/08/2016

                    Its exceptional performance, coupled with its ability to generate clear and precise protein bands, make it an indispensable tool in achieving accurate and reliable results.

                    04/05/2016

                      The ARHGAP4 protein exhibits a high degree of specificity in various assays, ensuring accurate and reliable results.

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