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ARHGAP5

  • Official Full Name

    Rho GTPase activating protein 5

  • Overview

    Rho GTPase activating protein 5 negatively regulates RHO GTPases, a family which may mediate cytoskeleton changes by stimulating the hydrolysis of bound GTP. Two transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    ARHGAP5; Rho GTPase activating protein 5; GFI2, growth factor independent 2; rho GTPase-activating protein 5; p190 B; p190BRhoGAP; RhoGAP5; ARHGAP 5; p190 RhoGAP; RhoGAP 5; RhoGAP; p105 RhoGAP; OTTHUMP00000244094; OTTHUMP00000244095; OTTHUMP00000244097; OTTHUMP00000244099; growth factor independent 2; p100 RasGAP-associated p105 protein; rho-type GTPase-activating protein 5; GFI2; p190-B;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ARHGAP5-8737HCL Recombinant Human ARHGAP5 293 Cell Lysate HEK293 N/A
Rhesus Macaque ARHGAP5-393R Recombinant Rhesus monkey ARHGAP5 Protein, His-tagged Mammalian Cell His
Rhesus Macaque ARHGAP5-222R Recombinant Rhesus Macaque ARHGAP5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque ARHGAP5-222R-B Recombinant Rhesus Macaque ARHGAP5 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ARHGAP5 Related Articles

ARHGAP5 involved in several pathways and played different roles in them. We selected most pathways ARHGAP5 participated on our site, such as Focal adhesion, Leukocyte transendothelial migration, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARHGAP5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Focal adhesionITGB6;PAK3;MYL12.1;ACTN3A;HRAS;PIK3CB;RAF1A;COL24A1;PIK3R3A
Leukocyte transendothelial migrationCLDN14;PTK2;ICAM1;CLDN22;MAPK13;MAPK12;ACTN3;MAPK11;VAV2

ARHGAP5 has several biochemical functions, for example, GTP binding, GTPase activator activity, GTPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ARHGAP5 itself. We selected most functions ARHGAP5 had, and list some proteins which have the same functions with ARHGAP5. You can find most of the proteins on our site.

Function Related Protein
GTP bindingRAB27B;TUBA8;EHD2B;DNM1B;ERAL1;RAB34;NPR1;EHD1B;TUBB2
GTPase activator activityARHGAP22;ARFGAP3;TBC1D22B;MURC;EVI5L;ASAP3;ARHGDIB;RGS2;STARD13
GTPase activityRAB1B;GBP1;RAB40C;EIF5;TUBA1L2;EEF1A2;AGAP2;TUBB5;GTPBP2
SH2 domain bindingSIT1;SYNGR3;INPPL1;GNB2L1;NLK;SKAP1;DLC1;SQSTM1;DAG1
protein bindingAPOD;GDI1;MYO7A;HSPB9;MTMR7;CDA;PIP5K1B;RHBDD1;PDE1B

ARHGAP5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARHGAP5 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARHGAP5.

Rnd3; SMURF2

Jarius, S; Scharf, M; et al. Antibodies to the inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) in cerebellar ataxia. Journal of Neuroinflammation 11:-(2014).
Zhang, QP; Zhang, HY; et al. srGAP3 promotes neurite outgrowth of dorsal root ganglion neurons by inactivating RAC1. ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE 7:630-638(2014).
  • Q&As
  • Reviews

Q&As (9)

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Are there any known diseases or disorders associated with ARHGAP5? 03/28/2023

While ARHGAP5 mutations have been linked to intellectual disability and developmental delay in some cases, there are no specific diseases or disorders that are primarily associated with ARHGAP5 dysfunction. However, given its role in essential cellular processes like cell migration and adhesion, dysregulation of ARHGAP5 may potentially contribute to various diseases, including cancer, cardiovascular diseases, and neurological disorders. Further research is needed to uncover the specific implications of ARHGAP5 in these conditions.

Are there any known mutations or genetic variants in the ARHGAP5 gene? 01/04/2022

Yes, mutations and genetic variants in the ARHGAP5 gene have been reported. For example, some studies have identified ARHGAP5 mutations in patients with intellectual disability and developmental delay. Additionally, certain genetic variants in ARHGAP5 have been associated with susceptibility to certain conditions and diseases, such as myocardial infarction and hypertension. However, further research is needed to fully understand the impact of these mutations and variants on ARHGAP5 function and disease development.

How is ARHGAP5 involved in cell migration? 07/09/2021

ARHGAP5 is involved in cell migration by regulating the activity of Rho GTPases, particularly RhoA, Rac1, and CDC42. These GTPases play key roles in actin cytoskeletal dynamics, which are critical for cell migration. ARHGAP5 functions as a GAP, catalyzing the hydrolysis of GTP bound to these GTPases, thereby converting them from an active GTP-bound state to an inactive GDP-bound state. This inactivation of Rho GTPases ultimately leads to the remodeling of the actin cytoskeleton and the regulation of cell migration.

Is ARHGAP5 involved in cancer progression? 08/17/2020

Yes, ARHGAP5 has been implicated in cancer progression and metastasis. Its regulation of Rho GTPases, particularly RhoA, Rac1, and CDC42, influences key processes involved in cancer metastasis, such as cell migration, invasion, and adhesion. Modulation of ARHGAP5 expression or activity can affect tumor cell behavior and metastatic potential, making it an important factor in cancer biology. However, more research is needed to fully elucidate the specific mechanisms by which ARHGAP5 contributes to cancer progression and to explore its potential as a therapeutic target.

In which tissues or organs is ARHGAP5 predominantly expressed? 07/28/2019

ARHGAP5 is expressed in various tissues and cell types. It is most abundant in tissues with high cellular turnover and active migration processes, such as the brain, lung, kidney, and intestines. However, ARHGAP5 expression levels can vary across different cell types within these tissues. For example, in the brain, ARHGAP5 is mainly expressed in the hippocampus, which is involved in learning and memory. Further studies are needed to better understand the tissue-specific expression and cellular localization of ARHGAP5.

Can ARHGAP5 be phosphorylated or post-translationally modified? 03/14/2019

Yes, ARHGAP5 can undergo post-translational modifications, including phosphorylation. Phosphorylation of ARHGAP5 at specific sites can regulate its activity and interactions with other proteins. For example, phosphorylation of ARHGAP5 by protein kinases like PAK1 and Aurora A can modulate its ability to interact with Rho GTPases and regulate their activity. Other post-translational modifications, such as acetylation and ubiquitination, have also been suggested to potentially impact ARHGAP5 function. Understanding the precise role of these modifications is an active area of research.

Does ARHGAP5 have any role in neuronal development or function? 11/25/2018

The expression and function of ARHGAP5 in neuronal development and function have not been extensively studied. However, Rho GTPases, which are regulated by ARHGAP5, are known to play important roles in neuronal processes such as neurite outgrowth, axon guidance, and synapse formation. It is possible that ARHGAP5, as a regulator of Rho GTPase activity, may also contribute to these processes. Further research is needed to determine the specific involvement of ARHGAP5 in neuronal development and function.

Are there any known interacting proteins of ARHGAP5? 02/15/2018

Yes, ARHGAP5 interacts with several proteins to modulate its activity and function. For example, ARHGAP5 has been shown to interact with paxillin, a focal adhesion protein involved in cell adhesion and migration. This interaction suggests a role for ARHGAP5 in regulating focal adhesion dynamics. Additionally, ARHGAP5 has been found to interact with other proteins involved in Rho GTPase signaling pathways, including the Rho GTPases themselves, regulatory proteins like Rho guanine nucleotide exchange factors (GEFs), and other GAPs. These protein interactions likely contribute to the precise regulation of ARHGAP5 activity and downstream cellular processes.

Can ARHGAP5 be targeted for therapeutic interventions? 12/05/2017

Targeting ARHGAP5 for therapeutics is a possibility, considering its involvement in various cellular processes and its potential role in diseases such as cancer. However, further research is needed to fully understand the functions and regulatory mechanisms of ARHGAP5, as well as its specific roles in disease pathogenesis. Developing targeted therapies that selectively modulate ARHGAP5 activity without affecting other essential cellular functions may present a challenge. Nevertheless, exploring the therapeutic potential of ARHGAP5 is an area of interest for future research.

Customer Reviews (10)

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Reviews
12/17/2022

    With their meticulous documentation and support, I am confident that my utilization of ARHGAP5 protein in clinical trials will meet all necessary regulations and guidelines.

    08/24/2022

      the excellent technical support provided by the manufacturer is of immense value to me.

      08/18/2021

        In addition to the remarkable quality of the protein, the manufacturer's support extends beyond the provision of the product itself.

        05/07/2020

          The ability to customize the ARHGAP5 protein variants or modifications offered by the manufacturer is also advantageous, as it allows me to tailor the protein to my specific research objectives.

          03/15/2019

            Manufacturers should ensure the consistency and quality of ARHGAP5 protein products.

            03/07/2018

              Additionally, cost-effectiveness, competitive pricing, and bulk purchase options can also be advantageous for researchers working within limited budgets.

              10/31/2017

                I appreciate the manufacturer's commitment to maintaining exceptional protein quality standards, which ensures reliable and consistent results in my trials.

                08/27/2017

                  Its purity, stability, and functionality make it an ideal choice for my research endeavors.

                  09/17/2016

                    The ARHGAP5 protein offered by the manufacturer exhibits exceptional quality and is precisely tailored to meet my experimental requirements.

                    07/10/2016

                      A manufacturer that offers customization options can enable the researcher to adhere to their experimental design requirements more effectively.

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