ARHGAP5
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Official Full Name
Rho GTPase activating protein 5
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Overview
Rho GTPase activating protein 5 negatively regulates RHO GTPases, a family which may mediate cytoskeleton changes by stimulating the hydrolysis of bound GTP. Two transcript variants encoding different isoforms have been found for this gene. -
Synonyms
ARHGAP5; Rho GTPase activating protein 5; GFI2, growth factor independent 2; rho GTPase-activating protein 5; p190 B; p190BRhoGAP; RhoGAP5; ARHGAP 5; p190 RhoGAP; RhoGAP 5; RhoGAP; p105 RhoGAP; OTTHUMP00000244094; OTTHUMP00000244095; OTTHUMP00000244097; OTTHUMP00000244099; growth factor independent 2; p100 RasGAP-associated p105 protein; rho-type GTPase-activating protein 5; GFI2; p190-B;
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | ARHGAP5-8737HCL | Recombinant Human ARHGAP5 293 Cell Lysate | HEK293 | N/A | ||
Rhesus Macaque | ARHGAP5-393R | Recombinant Rhesus monkey ARHGAP5 Protein, His-tagged | Mammalian Cell | His | ||
Rhesus Macaque | ARHGAP5-222R | Recombinant Rhesus Macaque ARHGAP5 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Rhesus Macaque | ARHGAP5-222R-B | Recombinant Rhesus Macaque ARHGAP5 Protein Pre-coupled Magnetic Beads | HEK293 |
- Involved Pathway
- Protein Function
- Interacting Protein
- ARHGAP5 Related Articles
ARHGAP5 involved in several pathways and played different roles in them. We selected most pathways ARHGAP5 participated on our site, such as Focal adhesion, Leukocyte transendothelial migration, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARHGAP5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Focal adhesion | ITGB6;PAK3;MYL12.1;ACTN3A;HRAS;PIK3CB;RAF1A;COL24A1;PIK3R3A |
Leukocyte transendothelial migration | CLDN14;PTK2;ICAM1;CLDN22;MAPK13;MAPK12;ACTN3;MAPK11;VAV2 |
ARHGAP5 has several biochemical functions, for example, GTP binding, GTPase activator activity, GTPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ARHGAP5 itself. We selected most functions ARHGAP5 had, and list some proteins which have the same functions with ARHGAP5. You can find most of the proteins on our site.
Function | Related Protein |
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GTP binding | RAB27B;TUBA8;EHD2B;DNM1B;ERAL1;RAB34;NPR1;EHD1B;TUBB2 |
GTPase activator activity | ARHGAP22;ARFGAP3;TBC1D22B;MURC;EVI5L;ASAP3;ARHGDIB;RGS2;STARD13 |
GTPase activity | RAB1B;GBP1;RAB40C;EIF5;TUBA1L2;EEF1A2;AGAP2;TUBB5;GTPBP2 |
SH2 domain binding | SIT1;SYNGR3;INPPL1;GNB2L1;NLK;SKAP1;DLC1;SQSTM1;DAG1 |
protein binding | APOD;GDI1;MYO7A;HSPB9;MTMR7;CDA;PIP5K1B;RHBDD1;PDE1B |
ARHGAP5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARHGAP5 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARHGAP5.
Rnd3; SMURF2
- Q&As
- Reviews
Q&As (9)
Ask a questionWhile ARHGAP5 mutations have been linked to intellectual disability and developmental delay in some cases, there are no specific diseases or disorders that are primarily associated with ARHGAP5 dysfunction. However, given its role in essential cellular processes like cell migration and adhesion, dysregulation of ARHGAP5 may potentially contribute to various diseases, including cancer, cardiovascular diseases, and neurological disorders. Further research is needed to uncover the specific implications of ARHGAP5 in these conditions.
Yes, mutations and genetic variants in the ARHGAP5 gene have been reported. For example, some studies have identified ARHGAP5 mutations in patients with intellectual disability and developmental delay. Additionally, certain genetic variants in ARHGAP5 have been associated with susceptibility to certain conditions and diseases, such as myocardial infarction and hypertension. However, further research is needed to fully understand the impact of these mutations and variants on ARHGAP5 function and disease development.
ARHGAP5 is involved in cell migration by regulating the activity of Rho GTPases, particularly RhoA, Rac1, and CDC42. These GTPases play key roles in actin cytoskeletal dynamics, which are critical for cell migration. ARHGAP5 functions as a GAP, catalyzing the hydrolysis of GTP bound to these GTPases, thereby converting them from an active GTP-bound state to an inactive GDP-bound state. This inactivation of Rho GTPases ultimately leads to the remodeling of the actin cytoskeleton and the regulation of cell migration.
Yes, ARHGAP5 has been implicated in cancer progression and metastasis. Its regulation of Rho GTPases, particularly RhoA, Rac1, and CDC42, influences key processes involved in cancer metastasis, such as cell migration, invasion, and adhesion. Modulation of ARHGAP5 expression or activity can affect tumor cell behavior and metastatic potential, making it an important factor in cancer biology. However, more research is needed to fully elucidate the specific mechanisms by which ARHGAP5 contributes to cancer progression and to explore its potential as a therapeutic target.
ARHGAP5 is expressed in various tissues and cell types. It is most abundant in tissues with high cellular turnover and active migration processes, such as the brain, lung, kidney, and intestines. However, ARHGAP5 expression levels can vary across different cell types within these tissues. For example, in the brain, ARHGAP5 is mainly expressed in the hippocampus, which is involved in learning and memory. Further studies are needed to better understand the tissue-specific expression and cellular localization of ARHGAP5.
Yes, ARHGAP5 can undergo post-translational modifications, including phosphorylation. Phosphorylation of ARHGAP5 at specific sites can regulate its activity and interactions with other proteins. For example, phosphorylation of ARHGAP5 by protein kinases like PAK1 and Aurora A can modulate its ability to interact with Rho GTPases and regulate their activity. Other post-translational modifications, such as acetylation and ubiquitination, have also been suggested to potentially impact ARHGAP5 function. Understanding the precise role of these modifications is an active area of research.
The expression and function of ARHGAP5 in neuronal development and function have not been extensively studied. However, Rho GTPases, which are regulated by ARHGAP5, are known to play important roles in neuronal processes such as neurite outgrowth, axon guidance, and synapse formation. It is possible that ARHGAP5, as a regulator of Rho GTPase activity, may also contribute to these processes. Further research is needed to determine the specific involvement of ARHGAP5 in neuronal development and function.
Yes, ARHGAP5 interacts with several proteins to modulate its activity and function. For example, ARHGAP5 has been shown to interact with paxillin, a focal adhesion protein involved in cell adhesion and migration. This interaction suggests a role for ARHGAP5 in regulating focal adhesion dynamics. Additionally, ARHGAP5 has been found to interact with other proteins involved in Rho GTPase signaling pathways, including the Rho GTPases themselves, regulatory proteins like Rho guanine nucleotide exchange factors (GEFs), and other GAPs. These protein interactions likely contribute to the precise regulation of ARHGAP5 activity and downstream cellular processes.
Targeting ARHGAP5 for therapeutics is a possibility, considering its involvement in various cellular processes and its potential role in diseases such as cancer. However, further research is needed to fully understand the functions and regulatory mechanisms of ARHGAP5, as well as its specific roles in disease pathogenesis. Developing targeted therapies that selectively modulate ARHGAP5 activity without affecting other essential cellular functions may present a challenge. Nevertheless, exploring the therapeutic potential of ARHGAP5 is an area of interest for future research.
Customer Reviews (10)
Write a reviewWith their meticulous documentation and support, I am confident that my utilization of ARHGAP5 protein in clinical trials will meet all necessary regulations and guidelines.
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I appreciate the manufacturer's commitment to maintaining exceptional protein quality standards, which ensures reliable and consistent results in my trials.
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The ARHGAP5 protein offered by the manufacturer exhibits exceptional quality and is precisely tailored to meet my experimental requirements.
A manufacturer that offers customization options can enable the researcher to adhere to their experimental design requirements more effectively.
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