Recombinant Rhesus Macaque ARHGAP5 Protein Pre-coupled Magnetic Beads
Cat.No. : | ARHGAP5-222R-B |
Product Overview : | The Recombnant protein was conjugated to magnetic beads. This ready-to-use, pre-coupled magnetic beads are in uniform particle size and narrow size distribution with large surface area, which is conducive to convenient and fast capture target molecules with high specificity and achieve magnetic separation. This product can be equipped with automation equipment for high-throughput operations. |
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Source : | HEK293 |
Species : | Rhesus Macaque |
Form : | Solution |
Particle size : | ~2 μm |
Beads Surface : | Hydrophilic |
Capacity : | > 200 pmol rabbit IgG/ mg beads |
Applications : | Immunoassay, In vitro diagnostics, cell sorting, Immunoprecipitation/Co-precipitation, Protein/antibody separation and purification. |
Stability : | Stable for at least 6 months from the date of receipt of the product under proper storage and handling conditions. |
Storage : | 2-8℃. Do not to freeze thaw the Beads |
Concentration : | 10mg beads/mL |
Storage Buffer : | PBS buffer |
Gene Name : | ARHGAP5 Rho GTPase activating protein 5 [ Macaca mulatta (Rhesus monkey) ] |
Official Symbol : | ARHGAP5 |
Synonyms : | ARHGAP5; Rho GTPase activating protein 5; rho GTPase-activating protein 5; |
Gene ID : | 100430157 |
mRNA Refseq : | NM_001198663 |
Protein Refseq : | NP_001185592 |
UniProt ID : | F7GRE8 |
Products Types
◆ Recombinant Protein | ||
ARHGAP5-222R | Recombinant Rhesus Macaque ARHGAP5 Protein, His (Fc)-Avi-tagged | +Inquiry |
ARHGAP5-393R | Recombinant Rhesus monkey ARHGAP5 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
ARHGAP5-8737HCL | Recombinant Human ARHGAP5 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (10)
Write a reviewWith their meticulous documentation and support, I am confident that my utilization of ARHGAP5 protein in clinical trials will meet all necessary regulations and guidelines.
the excellent technical support provided by the manufacturer is of immense value to me.
In addition to the remarkable quality of the protein, the manufacturer's support extends beyond the provision of the product itself.
The ability to customize the ARHGAP5 protein variants or modifications offered by the manufacturer is also advantageous, as it allows me to tailor the protein to my specific research objectives.
Manufacturers should ensure the consistency and quality of ARHGAP5 protein products.
Additionally, cost-effectiveness, competitive pricing, and bulk purchase options can also be advantageous for researchers working within limited budgets.
I appreciate the manufacturer's commitment to maintaining exceptional protein quality standards, which ensures reliable and consistent results in my trials.
Its purity, stability, and functionality make it an ideal choice for my research endeavors.
The ARHGAP5 protein offered by the manufacturer exhibits exceptional quality and is precisely tailored to meet my experimental requirements.
A manufacturer that offers customization options can enable the researcher to adhere to their experimental design requirements more effectively.
Q&As (9)
Ask a questionWhile ARHGAP5 mutations have been linked to intellectual disability and developmental delay in some cases, there are no specific diseases or disorders that are primarily associated with ARHGAP5 dysfunction. However, given its role in essential cellular processes like cell migration and adhesion, dysregulation of ARHGAP5 may potentially contribute to various diseases, including cancer, cardiovascular diseases, and neurological disorders. Further research is needed to uncover the specific implications of ARHGAP5 in these conditions.
Yes, mutations and genetic variants in the ARHGAP5 gene have been reported. For example, some studies have identified ARHGAP5 mutations in patients with intellectual disability and developmental delay. Additionally, certain genetic variants in ARHGAP5 have been associated with susceptibility to certain conditions and diseases, such as myocardial infarction and hypertension. However, further research is needed to fully understand the impact of these mutations and variants on ARHGAP5 function and disease development.
ARHGAP5 is involved in cell migration by regulating the activity of Rho GTPases, particularly RhoA, Rac1, and CDC42. These GTPases play key roles in actin cytoskeletal dynamics, which are critical for cell migration. ARHGAP5 functions as a GAP, catalyzing the hydrolysis of GTP bound to these GTPases, thereby converting them from an active GTP-bound state to an inactive GDP-bound state. This inactivation of Rho GTPases ultimately leads to the remodeling of the actin cytoskeleton and the regulation of cell migration.
Yes, ARHGAP5 has been implicated in cancer progression and metastasis. Its regulation of Rho GTPases, particularly RhoA, Rac1, and CDC42, influences key processes involved in cancer metastasis, such as cell migration, invasion, and adhesion. Modulation of ARHGAP5 expression or activity can affect tumor cell behavior and metastatic potential, making it an important factor in cancer biology. However, more research is needed to fully elucidate the specific mechanisms by which ARHGAP5 contributes to cancer progression and to explore its potential as a therapeutic target.
ARHGAP5 is expressed in various tissues and cell types. It is most abundant in tissues with high cellular turnover and active migration processes, such as the brain, lung, kidney, and intestines. However, ARHGAP5 expression levels can vary across different cell types within these tissues. For example, in the brain, ARHGAP5 is mainly expressed in the hippocampus, which is involved in learning and memory. Further studies are needed to better understand the tissue-specific expression and cellular localization of ARHGAP5.
Yes, ARHGAP5 can undergo post-translational modifications, including phosphorylation. Phosphorylation of ARHGAP5 at specific sites can regulate its activity and interactions with other proteins. For example, phosphorylation of ARHGAP5 by protein kinases like PAK1 and Aurora A can modulate its ability to interact with Rho GTPases and regulate their activity. Other post-translational modifications, such as acetylation and ubiquitination, have also been suggested to potentially impact ARHGAP5 function. Understanding the precise role of these modifications is an active area of research.
The expression and function of ARHGAP5 in neuronal development and function have not been extensively studied. However, Rho GTPases, which are regulated by ARHGAP5, are known to play important roles in neuronal processes such as neurite outgrowth, axon guidance, and synapse formation. It is possible that ARHGAP5, as a regulator of Rho GTPase activity, may also contribute to these processes. Further research is needed to determine the specific involvement of ARHGAP5 in neuronal development and function.
Yes, ARHGAP5 interacts with several proteins to modulate its activity and function. For example, ARHGAP5 has been shown to interact with paxillin, a focal adhesion protein involved in cell adhesion and migration. This interaction suggests a role for ARHGAP5 in regulating focal adhesion dynamics. Additionally, ARHGAP5 has been found to interact with other proteins involved in Rho GTPase signaling pathways, including the Rho GTPases themselves, regulatory proteins like Rho guanine nucleotide exchange factors (GEFs), and other GAPs. These protein interactions likely contribute to the precise regulation of ARHGAP5 activity and downstream cellular processes.
Targeting ARHGAP5 for therapeutics is a possibility, considering its involvement in various cellular processes and its potential role in diseases such as cancer. However, further research is needed to fully understand the functions and regulatory mechanisms of ARHGAP5, as well as its specific roles in disease pathogenesis. Developing targeted therapies that selectively modulate ARHGAP5 activity without affecting other essential cellular functions may present a challenge. Nevertheless, exploring the therapeutic potential of ARHGAP5 is an area of interest for future research.
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