ARHGEF10L
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Official Full Name
Rho guanine nucleotide exchange factor (GEF) 10-like
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Synonyms
ARHGEF10L;Rho guanine nucleotide exchange factor (GEF) 10-like;25540;ENSG00000074964;GrinchGEF;RP11-473A10.1;1p36.13;FLJ10521, KIAA1626;rho guanine nucleotide exchange factor 10-like protein;rho guanine nucleotide exchange factor 10-like protein;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- Mammalian cells
- Flag
- His
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- Involved Pathway
- Protein Function
- Interacting Protein
ARHGEF10L involved in several pathways and played different roles in them. We selected most pathways ARHGEF10L participated on our site, such as Regulation of RhoA activity, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARHGEF10L were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Regulation of RhoA activity | PLEKHG6;AKAP13;ARHGEF10;ARHGEF25;MYO9B;MCF2L;ECT2;DEF6;ABR |
ARHGEF10L has several biochemical functions, for example, Rho guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ARHGEF10L itself. We selected most functions ARHGEF10L had, and list some proteins which have the same functions with ARHGEF10L. You can find most of the proteins on our site.
Function | Related Protein |
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Rho guanyl-nucleotide exchange factor activity | NET1;C9orf100;PLEKHG3;FGD5;PLEKHG5;ARHGEF10;ARHGEF18A;ITSN2;PLEKHG4 |
ARHGEF10L has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARHGEF10L here. Most of them are supplied by our site. Hope this information will be useful for your research of ARHGEF10L.
ANXA9; NR4A1; DRAP1; ul07_ebvg; SCN2A; pi3p
- Q&As
- Reviews
Q&As (12)
Ask a questionCurrently, there is limited information regarding disease-associated mutations in the ARHGEF10L gene. More research is needed to determine if mutations in ARHGEF10L contribute to any specific disorders or diseases.
ARHGEF10L contains several known functional domains and motifs. It harbors an N-terminal coiled-coil domain, which is involved in protein-protein interactions, as well as a Dbl homology (DH) domain and a pleckstrin homology (PH) domain. The DH domain is responsible for the guanine nucleotide exchange factor (GEF) activity of ARHGEF10L, activating Rho GTPases by catalyzing the exchange of GDP for GTP. The PH domain is often involved in membrane targeting and binding phosphoinositides. Additionally, ARHGEF10L contains a C-terminal proline-rich domain that might also participate in protein-protein interactions.
The specific interactors and binding partners of ARHGEF10L have not been extensively characterized. However, it is anticipated that ARHGEF10L might interact with Rho GTPases, as well as other proteins involved in cellular processes regulated by Rho GTPases, such as actin cytoskeleton remodeling and cell adhesion. Further studies are needed to identify and validate the interactors of ARHGEF10L.
Currently, there are no documented knockout or knockdown studies specifically targeting ARHGEF10L. The functional characterization of ARHGEF10L and its physiological role would benefit from further studies using knockout or knockdown models.
ARHGEF10L exhibits conservation across various species, including mammals, birds, reptiles, amphibians, and fish. Comparative sequence analysis reveals a significant degree of conservation within the functional domains, suggesting an important evolutionary role. This conservation indicates that ARHGEF10L likely plays a conserved function in cellular processes across different species.
The specific signaling pathways in which ARHGEF10L participates are not well characterized. However, as a Rho GEF, it is likely involved in signaling pathways that regulate cytoskeletal dynamics, such as those mediated by Rho GTPases. Further research is needed to elucidate the precise signaling mechanisms in which ARHGEF10L is involved.
The cellular localization of ARHGEF10L is not extensively studied. However, it is predicted to have a cytoplasmic localization based on its protein structure and function as a Rho GEF. Further experimental investigation is required to determine its precise cellular localization.
The specific interactions and regulators of ARHGEF10L are still being investigated. However, it is likely that ARHGEF10L interacts with Rho GTPases and other downstream effectors to regulate cellular processes. Furthermore, other proteins or signaling molecules may also modulate the activity of ARHGEF10L, but more research is needed to determine the full extent of its interactors and regulators.
As of now, there is limited information linking ARHGEF10L directly to cancer or other diseases. However, given its association with Rho GTPases, which are implicated in cell migration, invasion, and proliferation, it is plausible that dysregulation of ARHGEF10L could contribute to disease progression. More research is required to investigate whether ARHGEF10L alterations play a role in disease development.
Currently, there is limited information regarding alternative splice isoforms of ARHGEF10L. Further genomic and transcriptomic studies are needed to determine if ARHGEF10L has any alternative splicing variants.
Currently, there are no well-documented functional studies specifically investigating ARHGEF10L in cellular or animal models. This lack of comprehensive functional research underscores the need for further studies to elucidate the biological functions and mechanisms of ARHGEF10L in both physiological and pathological conditions.
ARHGEF10L has several known orthologs and paralogs. Orthologs of ARHGEF10L can be found in different species, including ARHGEF10 in humans and Arhgef10 in mice, which share significant sequence similarity. Paralogs of ARHGEF10L, which are related genes arising from gene duplication events within a genome, include other Rho GEFs such as ARHGEF10B and ARHGEF10L2. These paralogs might have similar or distinct functions compared to ARHGEF10L, warranting further investigation.
Customer Reviews (8)
Write a reviewThe manufacturer also offers valuable customer support, actively aiding researchers in their experimental journey.
Their technical expertise, product quality, customer support, and supply management collectively contribute to the success and progress of my trials.
This can be advantageous in understanding disease mechanisms and developing novel therapeutics.
Structural biology researchers can leverage its properties to better understand the three-dimensional architecture and conformational changes of proteins, gaining valuable insights into their function and interactions.
They ensure the purity, integrity, and functionality of ARHGEF10L protein through rigorous quality control measures.
ARHGEF10L protein might have biomarker properties, meaning its levels or activity could be indicative of disease progression or treatment response.
Its purity, integrity, and functionality are ensured through stringent quality control measures, which instills confidence in the reliability and accuracy of my research results.
ARHGEF10L protein is highly recommended for various research applications, including ELISA and protein electron microscopy structure analysis.
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