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ARHGEF16

  • Official Full Name

    Rho guanine nucleotide exchange factor (GEF) 16

  • Overview

    Although the specific function of this protein is not known yet, it is thought to be involved in protein-protein and protein-lipid interactions.
  • Synonyms

    ARHGEF16; Rho guanine nucleotide exchange factor (GEF) 16; rho guanine nucleotide exchange factor 16; GEF16; NBR; putative neuroblastoma protein; ARHGEF 16; Rho guanine exchange factor (GEF) 16; ephexin-4;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
  • T7
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ARHGEF16-2984H Recombinant Human ARHGEF16, T7-tagged E.coli T7
Human ARHGEF16-782H Recombinant Human ARHGEF16 protein, GST-tagged Wheat Germ GST
Human ARHGEF16-117HCL Recombinant Human ARHGEF16 cell lysate N/A
Human ARHGEF16-1226HF Recombinant Full Length Human ARHGEF16 Protein, GST-tagged In Vitro Cell Free System GST 421 amino acids
Human ARHGEF16-2696H Recombinant Human ARHGEF16 Protein, His-tagged E.coli His
Mouse ARHGEF16-1891M Recombinant Mouse ARHGEF16 Protein Mammalian Cell His
Mouse ARHGEF16-692M-B Recombinant Mouse ARHGEF16 Protein Pre-coupled Magnetic Beads HEK293
Mouse ARHGEF16-692M Recombinant Mouse ARHGEF16 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish ARHGEF16-6671Z Recombinant Zebrafish ARHGEF16 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

ARHGEF16 involved in several pathways and played different roles in them. We selected most pathways ARHGEF16 participated on our site, such as Cell death signalling via NRAGE, NRIF and NADE, G alpha (12/13) signalling events, GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARHGEF16 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cell death signalling via NRAGE, NRIF and NADEARHGAP4A;MCF2L;ITSN1;ARHGEF16;TIAM2;NET1;AATF;TRIO;DCLRE1B
G alpha (12/13) signalling eventsADRA1D;ECT2;ARHGEF3;DCLRE1B;AKAP13;ARHGAP4;TIAM2;KALRNB;FGD2
GPCR downstream signalingFGD4;GHRH;PYYA;CNR2;PROKR2;PNOC;ADORA1;CXCL11.8;SCT
NRAGE signals death through JNKARHGEF17;ARHGEF18;ARHGEF1A;ARHGAP4A;FGD4A;NET1;ABR;ARHGAP4;ARHGEF3
Rho GTPase cycleAKAP13;ARHGAP18;ARHGEF1A;RHOU;ARHGAP15;ECT2;DEPDC7;FAM13B1;GMIP
Signal TransductionGPR161;RGS1;FSTL1;ARHGAP4A;RYK;PDK2;RGS9BP;CDON;RGS21
Signaling by GPCRCXCL11.8;GAL;RGS18;NPB;CRHB;ZFPM2B;CCRL2;PLEKHG2;GPR55A
Signaling by Rho GTPasesLIN7B;ARHGAP1;OPHN1;RTKN;DLC1;ARHGAP31;ARHGAP17;ROPN1;ARHGAP24

ARHGEF16 has several biochemical functions, for example, PDZ domain binding, Rho GTPase binding, Rho guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ARHGEF16 itself. We selected most functions ARHGEF16 had, and list some proteins which have the same functions with ARHGEF16. You can find most of the proteins on our site.

Function Related Protein
PDZ domain bindingNSF;CXXC4;ACCN3;Apba1;F11R;SRR;NKD1;SLC22A5;ATP2B3A
Rho GTPase bindingARHGEF16;FMNL2;LRRK2;RHOH;KIF3B;ANTXR2A;DOCK10;FLNA;AKAP13
Rho guanyl-nucleotide exchange factor activityFGD4A;ARHGEF12;AKAP13;ARHGEF3;OBSCN;ITSN1;PLEKHG7;ARHGEF39;ARHGEF16
protein bindingGSTO2;STK38L;TXNL4B;UBAP2L;PSMD5;GNB3;DNMT1;TMEM182;CYLD
receptor tyrosine kinase bindingTP53;DOCK4;PITPNM3;SOCS5;PTPN1;GNB2L1;SHC4;PLCG1;CPNE3

ARHGEF16 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARHGEF16 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARHGEF16.

TFG; MAPK1IP1L; TFG; SFN; YWHAG; YWHAZ

  • Q&As
  • Reviews

Q&As (15)

Ask a question
Is ARHGEF16 associated with any diseases? 12/14/2022

Yes, dysregulation of ARHGEF16 has been implicated in various diseases, including cancer. Overexpression of ARHGEF16 has been observed in several cancer types, and it is associated with increased cell proliferation, invasion, and metastasis.

Are there any specific inhibitors or activators of ARHGEF16? 06/28/2022

Currently, there are no specific inhibitors or activators that exclusively target ARHGEF16. However, compounds targeting the RhoA GTPase, which is regulated by ARHGEF16, can indirectly affect its function. Additionally, manipulating the expression or activity of upstream regulators of ARHGEF16, such as small GTPase activating proteins (GAPs) or guanine nucleotide exchange factors (GEFs), may modulate ARHGEF16-mediated signaling.

What are the potential therapeutic implications of targeting ARHGEF16? 11/15/2021

Targeting ARHGEF16 holds promise for therapeutic interventions in various diseases. Since ARHGEF16 is involved in cell division and cytokinesis, it may be a target for cancer treatment, as inhibiting its activity could potentially prevent tumor growth and metastasis. In addition, ARHGEF16 has been linked to neurodevelopmental disorders, so targeting it could offer therapeutic approaches for conditions such as intellectual disability and autism spectrum disorders. However, further research is needed to fully understand the therapeutic potential of targeting ARHGEF16.

Can ARHGEF16 be used as a diagnostic marker for any diseases? 04/23/2021

As of now, ARHGEF16 is not routinely used as a diagnostic marker for any specific diseases. However, genetic variations or mutations in ARHGEF16 have been associated with certain neurodevelopmental disorders, and further research may reveal its potential diagnostic value in these conditions. It is important to note that the role of ARHGEF16 as a diagnostic marker would require extensive validation and understanding of its specific disease associations and mechanisms.

Is ARHGEF16 involved in any cellular signaling pathways? 01/27/2021

ARHGEF16 primarily functions as a regulator of RhoA GTPase activity during cell division and cytokinesis. While its direct involvement in other signaling pathways is not well-established, RhoA signaling is known to intersect with a variety of cellular pathways, including those involved in cytoskeletal dynamics, cell migration, and cell polarity.

Are there any known interactions between ARHGEF16 and other proteins? 07/30/2020

ARHGEF16 can interact with multiple proteins, including members of the Rho GTPase family, their regulators, and other proteins involved in cytoskeletal dynamics and cell signaling. For example, ARHGEF16 interacts with RhoA, which it activates by promoting the exchange of GDP for GTP. It can also interact with other Rho GTPases, such as RhoB and RhoC. Additionally, ARHGEF16 may interact with proteins involved in actin dynamics, such as actin-binding proteins and actin cytoskeleton regulators. These protein interactions contribute to the regulation of ARHGEF16 activity and its functions in various cellular processes.

How does ARHGEF16 contribute to cell division? 09/01/2018

ARHGEF16 is involved in the regulation of the RhoA GTPase, which controls actomyosin contractility and formation of the contractile ring during cytokinesis. ARHGEF16 ensures proper formation and constriction of the contractile ring, leading to successful cell division.

Does ARHGEF16 have any known protein interactions? 08/06/2018

ARHGEF16 interacts with several proteins involved in cell division and cytokinesis. One of its well-known binding partners is the RhoA GTPase, which it activates. ARHGEF16 also interacts with other regulators of Rho GTPases, such as Rho GTPase activating proteins (GAPs) and other guanine nucleotide exchange factors (GEFs). Additionally, ARHGEF16 interacts with other cytoskeletal proteins and signaling molecules involved in cell division.

Are there any known drugs or compounds that target ARHGEF16? 08/08/2017

Currently, there are no known drugs or compounds specifically designed to target ARHGEF16. However, research on small molecule inhibitors or modulators of related proteins in the Rho GTPase pathway, which ARHGEF16 is involved in, may indirectly impact the activity of ARHGEF16. Additionally, drug discovery efforts may focus on developing compounds that specifically target the functions of ARHGEF16 in various disease contexts, although such efforts are at an early stage.

Are there any genetic variations or mutations associated with ARHGEF16? 09/21/2016

Yes, studies have identified genetic variations and mutations in the ARHGEF16 gene. Some of these variations have been associated with neurodevelopmental disorders, such as intellectual disability and autism spectrum disorders. These mutations can disrupt the normal function of ARHGEF16 and lead to abnormal cellular processes.

Is ARHGEF16 involved in any signaling pathways? 08/01/2016

ARHGEF16 is primarily involved in the regulation of the Rho GTPase signaling pathway. It acts as a guanine nucleotide exchange factor (GEF) for RhoA, a member of the Rho GTPase family. By catalyzing the exchange of guanosine diphosphate (GDP) for guanosine triphosphate (GTP) on RhoA, ARHGEF16 activates RhoA and triggers downstream signaling events involved in cytoskeletal rearrangements, cell migration, cell division, and cytokinesis. Additionally, ARHGEF16 can interact with other signaling proteins and may be involved in other signaling pathways, although further research is needed to fully understand its broader signaling roles.

Are there any known genetic disorders or syndromes associated with mutations in ARHGEF16? 06/24/2016

Yes, mutations in ARHGEF16 have been associated with a neurodevelopmental disorder known as Bainbridge-Ropers syndrome (BRS). BRS is a rare genetic disorder characterized by developmental delay, intellectual disability, language impairment, and distinct facial features. The mutations in ARHGEF16 that cause BRS are usually de novo, meaning they occur for the first time in an affected individual and are not inherited from their parents. These mutations often affect the function of ARHGEF16, leading to abnormal neuronal development and impairments in cognitive and behavioral functions.

Are there any animal models available to study ARHGEF16? 06/20/2016

Yes, animal models have been developed to study ARHGEF16's function and its role in development and disease. For example, knockout mice lacking ARHGEF16 have been generated to understand its importance during embryonic development and cell division. These animal models provide valuable insights into ARHGEF16's biological roles and potential therapeutic implications.

Can ARHGEF16 be used as a potential therapeutic target? 02/04/2016

The dysregulation of ARHGEF16 in cancer suggests that it may be a potential therapeutic target. However, further research is needed to better understand its mechanisms of action and to develop specific inhibitors or strategies to target ARHGEF16 effectively. Additionally, its role in normal cellular processes and potential side effects of targeting ARHGEF16 need to be thoroughly investigated.

Are there any clinical studies or trials involving ARHGEF16? 01/08/2016

Currently, there are no known clinical studies or trials specifically focused on ARHGEF16. However, research on this gene and its potential therapeutic implications is ongoing. It may take some time before clinical trials involving ARHGEF16-based interventions are developed and conducted.

Customer Reviews (8)

Write a review
Reviews
03/11/2023

    Its versatility allows researchers to explore ARHGEF16 involvement in diverse biological processes and fully uncover its functional role.

    01/19/2021

      They actively engage with the scientific community, staying up-to-date with the latest advancements related to ARHGEF16 protein and sharing this valuable information.

      05/21/2019

        the ARHGEF16 protein's high quality, dependable performance, and comprehensive technical support make it an excellent choice for researchers seeking to investigate angiopoietin-related biology and unravel the complexities of vascular development and pathogenesis.

        11/02/2018

          To summarize, the ARHGEF16 protein provided by the manufacturer is of exceptional quality and perfectly aligns with my experimental requirements.

          09/06/2018

            It can also be employed in various molecular biology techniques, such as Western blotting, immunoprecipitation, or protein-protein interaction studies.

            02/16/2018

              the manufacturer's commitment to scientific collaboration and knowledge sharing greatly enhances my research experience.

              12/15/2016

                This reliable supply chain management guarantees uninterrupted access to the protein, allowing me to plan and conduct my experiments with confidence and without concern for availability issues.

                10/20/2016

                  Whether studying angiopoietin signaling pathways, vascular remodeling, or endothelial cell biology, the ARHGEF16 protein is an invaluable tool for researchers.

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