ARHGEF25
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Official Full Name
Rho guanine nucleotide exchange factor (GEF) 25
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Overview
Rho GTPases alternate between an inactive GDP-bound state and an active GTP-bound state, and GEFs facilitate GDP/GTP;exchange. This gene encodes a guanine nucleotide exchange factor (GEF) which interacts with Rho GTPases involved in;contraction of vascular smooth muscles, regulation of responses to angiotensin II and lens cell differentiation.;Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
ARHGEF25; Rho guanine nucleotide exchange factor (GEF) 25; rho guanine nucleotide exchange factor 25; GEFT; p63RhoGEF; RAC/CDC42 exchange factor; Rac/Cdc42/Rho exchange factor GEFT; RhoA/RAC/CDC42 exchange factor; RhoA/Rac/Cdc42 guanine nucleotide exchange factor GEFT; guanine nucleotide exchange factor GEFT;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- HEK293
- Mammalian Cell
- His
- His (Fc)
- Avi
- N/A
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Human | ARHGEF25-975H | Recombinant Human ARHGEF25 | Mammalian Cell | His | ||
Human | ARHGEF25-5962HCL | Recombinant Human GEFT 293 Cell Lysate | HEK293 | N/A | ||
Human | ARHGEF25-2497H | Recombinant Human ARHGEF25 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Human | ARHGEF25-2497H-B | Recombinant Human ARHGEF25 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Mouse | ARHGEF25-1896M | Recombinant Mouse ARHGEF25 Protein | Mammalian Cell | His | ||
Mouse | ARHGEF25-696M-B | Recombinant Mouse ARHGEF25 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Mouse | ARHGEF25-696M | Recombinant Mouse ARHGEF25 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Rat | ARHGEF25-771R | Recombinant Rat ARHGEF25 Protein | Mammalian Cell | His | ||
Rat | ARHGEF25-427R-B | Recombinant Rat ARHGEF25 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Rat | ARHGEF25-427R | Recombinant Rat ARHGEF25 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
- Involved Pathway
- Protein Function
- Interacting Protein
ARHGEF25 involved in several pathways and played different roles in them. We selected most pathways ARHGEF25 participated on our site, such as G alpha (q) signalling events, GPCR downstream signaling, Gastrin-CREB signalling pathway via PKC and MAPK, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARHGEF25 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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G alpha (q) signalling events | PROK2;CYSLTR1;HCRT;GPR4;OXTRL;TRPC6A;PRKCHB;QRFPR;PROKR1A |
GPCR downstream signaling | RGS19;NMBA;RGS17;DRD5;OR56A1;VIP2;CRH;RGS21;RGS20 |
Gastrin-CREB signalling pathway via PKC and MAPK | TAC3;OPN4.1;GPRC6A;PMCH;GPR65;GPR4;ANXA1C;PROK1;GPR68 |
Regulation of CDC42 activity | ITSN2;ARHGEF25;DOCK6;MCF2L;SPATA13;DOCK9;DOCK10;ARHGAP17;DNMBP |
Regulation of RAC1 activity | DEF6;ABR;RAP1GDS1;EPS8;ARHGAP1;PREX2;DOCK6;ARHGAP9;RALBP1 |
Regulation of RhoA activity | MYO9B;ARHGEF25;PLEKHG6;AKAP13;FARP1;ARHGAP4;ARHGEF10L;ECT2;OBSCN |
Signal Transduction | FGFBP3;RGS4;RAMP3;PYYA;LEO1;SKIB;TMED5;CALML4;PRICKLE1B |
Signaling by GPCR | INSL5;ARHGEF3;ACKR4;PENK;GHRH;OPN1LW1;ARHGEF25;GPR31;PROKR1A |
ARHGEF25 has several biochemical functions, for example, Rho guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ARHGEF25 itself. We selected most functions ARHGEF25 had, and list some proteins which have the same functions with ARHGEF25. You can find most of the proteins on our site.
Function | Related Protein |
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Rho guanyl-nucleotide exchange factor activity | ARHGEF37;ITSN2B;AKAP13;PLEKHG6;VAV3B;ARHGEF7;TRIO;ARHGEF7A;FGD1 |
ARHGEF25 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARHGEF25 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARHGEF25.
- Q&As
- Reviews
Q&As (20)
Ask a questionAt present, there is limited information on animal models specific to ARHGEF25. However, general RhoGEF knockout or overexpression mouse models may provide insights into the function and regulation of ARHGEF25.
ARHGEF25 shows a certain degree of conservation across different species, indicating its importance in cellular processes. Conserved regions within the protein provide insights into its functional domains and potential roles in various organisms.
While there have been reported genetic variants in the ARHGEF25 gene, currently there is limited information regarding disease-associated mutations. Further studies are needed to determine the potential link between specific ARHGEF25 mutations and disease phenotypes.
ARHGEF25 has shown promise as a potential biomarker in certain cancers. High expression levels of ARHGEF25 have been associated with poor prognosis in colorectal cancer, gastric cancer, and breast cancer. However, additional research is needed to validate its potential as a diagnostic or prognostic biomarker in clinical settings.
Yes, besides cell migration, ARHGEF25 has also been implicated in other cellular processes such as cell adhesion, cell proliferation, and actin cytoskeleton organization.
While the role of ARHGEF25 in certain diseases is still being investigated, it has been implicated in cancer progression and metastasis. Studies have shown that increased expression of ARHGEF25 is associated with poor prognosis in various cancers, including colorectal cancer, gastric cancer, and breast cancer. Additionally, ARHGEF25 has been linked to neurological disorders such as Alzheimer's disease, where it may play a role in neuronal dysfunction and synaptic plasticity.
ARHGEF25 promotes cell migration by activating Rac1, a protein involved in cytoskeletal rearrangement and formation of lamellipodia, which are required for cell movement.
Currently, there is insufficient evidence to consider ARHGEF25 as a diagnostic or prognostic marker. However, ongoing research may uncover its potential utility in clinical applications in the future.
Yes, there have been reported genetic variants in the ARHGEF25 gene in certain populations. These variations can potentially affect the protein's function and may be associated with disease susceptibility or altered cellular processes.
As of now, there are no specific small molecule inhibitors or drugs known to target ARHGEF25. However, further investigation into its regulatory mechanisms may reveal potential therapeutic strategies in the future.
Currently, there is limited information regarding natural compounds or dietary factors that directly modulate ARHGEF25 expression or activity. Further research is needed to explore this aspect and identify potential natural modulators of ARHGEF25.
Broadening our knowledge of ARHGEF25 can help in understanding its potential involvement in other diseases, such as neurological disorders, cardiovascular conditions, or immune-related disorders. Exploring its functions and interactions may shed light on novel therapeutic targets and pathways in these diseases.
Yes, ARHGEF25 can interact with various signaling molecules and effector proteins. For example, it has been shown to interact with p21-activated kinase (PAK), an important downstream effector of Rac1 signaling.
Combining targeted therapies that inhibit ARHGEF25-associated pathways with existing drugs could potentially enhance their efficacy in treating certain diseases. However, more research is needed to identify specific therapeutic targets and evaluate the feasibility of combination therapies involving ARHGEF25.
As of now, there are no registered clinical trials specifically targeting ARHGEF25. However, given its involvement in cancer progression and metastasis, future studies may explore potential therapeutic strategies targeting ARHGEF25 or its related signaling pathways.
The regulation of ARHGEF25 can be influenced by several signaling pathways. For example, the Wnt/β-catenin signaling pathway has been shown to upregulate ARHGEF25 expression in certain cancer cell lines. Additionally, the MAPK/ERK pathway has also been implicated in the regulation of ARHGEF25 in cancer cells.
There is limited information on the role of ARHGEF25 in neuronal development. Most research on ARHGEF25 has focused on its involvement in cancer and cellular processes related to Rac1 signaling.
Currently, there are no specific inhibitors or activators of ARHGEF25. However, understanding its regulatory mechanisms and interactions might provide avenues for developing modulators of ARHGEF25 activity in the future.
The specific regulation of ARHGEF25 expression during development is not well understood. However, studies have shown that ARHGEF25 is expressed in various tissues during embryogenesis, suggesting its potential involvement in tissue morphogenesis and cellular differentiation.
Currently, there is limited information on ARHGEF25 mutations and associated diseases. Further research is needed to fully understand the implications of ARHGEF25 mutations in human health.
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