|Official Full Name||Rho guanine nucleotide exchange factor (GEF) 25|
|Background||Rho GTPases alternate between an inactive GDP-bound state and an active GTP-bound state, and GEFs facilitate GDP/GTP;exchange. This gene encodes a guanine nucleotide exchange factor (GEF) which interacts with Rho GTPases involved in;contraction of vascular smooth muscles, regulation of responses to angiotensin II and lens cell differentiation.;Multiple transcript variants encoding different isoforms have been found for this gene.|
|Synonyms||ARHGEF25; Rho guanine nucleotide exchange factor (GEF) 25; rho guanine nucleotide exchange factor 25; GEFT; p63RhoGEF; RAC/CDC42 exchange factor; Rac/Cdc42/Rho exchange factor GEFT; RhoA/RAC/CDC42 exchange factor; RhoA/Rac/Cdc42 guanine nucleotide exchange factor GEFT; guanine nucleotide exchange factor GEFT|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
ARHGEF25 involved in several pathways and played different roles in them. We selected most pathways ARHGEF25 participated on our site, such as G alpha (q) signalling events, GPCR downstream signaling, Gastrin-CREB signalling pathway via PKC and MAPK, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARHGEF25 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|G alpha (q) signalling events||TRIO; GCGB; PROKR2; CHRM3; LPAR2A; NMU; CCK; OXTRL; TAC1; OPN4.1|
|GPCR downstream signaling||OPN1MW2; ADCYAP1R1; TAAR1; OR56A1; RXFP2B; CRH; NPFF; PNOC; GAL; RHOGA|
|Gastrin-CREB signalling pathway via PKC and MAPK||ANXA1C; QRFPR; LPAR5A; PMCH; FFAR3; DGKG; GPR65; ANXA1; NPSR1; EDN2|
|Regulation of CDC42 activity||DOCK6; BCAR3; SPATA13; DNMBP; ITSN2; DOCK9; RALBP1; ARHGAP1; DOCK10; ARHGEF25|
|Regulation of RAC1 activity||ARHGEF25; DOCK6; RAP1GDS1; SPATA13; CHN2; CHN1; DEF6; RALBP1; ARHGAP17; EPS8|
|Regulation of RhoA activity||ABR; FARP1; OBSCN; ARHGEF28; DLC1; ECT2; MCF2L; ARHGEF15; AKAP13; MYO9B|
|Signal Transduction||USP15; SOUL4; NTS; OR4D2; ASH2L; CCNT2A; CXCL11.8; F11R.2; INTU; PDK2|
|Signaling by GPCR||RGS17; TAC3; OR56A1; OXER1; OPN4B; ADM2; PYYA; OR52J3; RGS6; ACKR4|
ARHGEF25 has several biochemical functions, for example, Rho guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ARHGEF25 itself. We selected most functions ARHGEF25 had, and list some proteins which have the same functions with ARHGEF25. You can find most of the proteins on our site.
|Rho guanyl-nucleotide exchange factor activity||VAV3; ARHGEF17; ITSN2B; PLEKHG5; ARHGEF19; OBSCN; ARHGEF33; C9orf100; ARHGEF1B; ARHGEF3L|
ARHGEF25 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARHGEF25 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARHGEF25.