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ARHGEF25

  • Official Full Name

    Rho guanine nucleotide exchange factor (GEF) 25

  • Overview

    Rho GTPases alternate between an inactive GDP-bound state and an active GTP-bound state, and GEFs facilitate GDP/GTP;exchange. This gene encodes a guanine nucleotide exchange factor (GEF) which interacts with Rho GTPases involved in;contraction of vascular smooth muscles, regulation of responses to angiotensin II and lens cell differentiation.;Multiple transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    ARHGEF25; Rho guanine nucleotide exchange factor (GEF) 25; rho guanine nucleotide exchange factor 25; GEFT; p63RhoGEF; RAC/CDC42 exchange factor; Rac/Cdc42/Rho exchange factor GEFT; RhoA/RAC/CDC42 exchange factor; RhoA/Rac/Cdc42 guanine nucleotide exchange factor GEFT; guanine nucleotide exchange factor GEFT;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • HEK293
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ARHGEF25-975H Recombinant Human ARHGEF25 Mammalian Cell His
Human ARHGEF25-5962HCL Recombinant Human GEFT 293 Cell Lysate HEK293 N/A
Human ARHGEF25-2497H Recombinant Human ARHGEF25 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human ARHGEF25-2497H-B Recombinant Human ARHGEF25 Protein Pre-coupled Magnetic Beads HEK293
Mouse ARHGEF25-1896M Recombinant Mouse ARHGEF25 Protein Mammalian Cell His
Mouse ARHGEF25-696M-B Recombinant Mouse ARHGEF25 Protein Pre-coupled Magnetic Beads HEK293
Mouse ARHGEF25-696M Recombinant Mouse ARHGEF25 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat ARHGEF25-771R Recombinant Rat ARHGEF25 Protein Mammalian Cell His
Rat ARHGEF25-427R-B Recombinant Rat ARHGEF25 Protein Pre-coupled Magnetic Beads HEK293
Rat ARHGEF25-427R Recombinant Rat ARHGEF25 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein

ARHGEF25 involved in several pathways and played different roles in them. We selected most pathways ARHGEF25 participated on our site, such as G alpha (q) signalling events, GPCR downstream signaling, Gastrin-CREB signalling pathway via PKC and MAPK, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARHGEF25 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
G alpha (q) signalling eventsPROK2;CYSLTR1;HCRT;GPR4;OXTRL;TRPC6A;PRKCHB;QRFPR;PROKR1A
GPCR downstream signalingRGS19;NMBA;RGS17;DRD5;OR56A1;VIP2;CRH;RGS21;RGS20
Gastrin-CREB signalling pathway via PKC and MAPKTAC3;OPN4.1;GPRC6A;PMCH;GPR65;GPR4;ANXA1C;PROK1;GPR68
Regulation of CDC42 activityITSN2;ARHGEF25;DOCK6;MCF2L;SPATA13;DOCK9;DOCK10;ARHGAP17;DNMBP
Regulation of RAC1 activityDEF6;ABR;RAP1GDS1;EPS8;ARHGAP1;PREX2;DOCK6;ARHGAP9;RALBP1
Regulation of RhoA activityMYO9B;ARHGEF25;PLEKHG6;AKAP13;FARP1;ARHGAP4;ARHGEF10L;ECT2;OBSCN
Signal TransductionFGFBP3;RGS4;RAMP3;PYYA;LEO1;SKIB;TMED5;CALML4;PRICKLE1B
Signaling by GPCRINSL5;ARHGEF3;ACKR4;PENK;GHRH;OPN1LW1;ARHGEF25;GPR31;PROKR1A

ARHGEF25 has several biochemical functions, for example, Rho guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ARHGEF25 itself. We selected most functions ARHGEF25 had, and list some proteins which have the same functions with ARHGEF25. You can find most of the proteins on our site.

Function Related Protein
Rho guanyl-nucleotide exchange factor activityARHGEF37;ITSN2B;AKAP13;PLEKHG6;VAV3B;ARHGEF7;TRIO;ARHGEF7A;FGD1

ARHGEF25 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARHGEF25 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARHGEF25.

  • Q&As
  • Reviews

Q&As (20)

Ask a question
Are there any animal models available for studying ARHGEF25? 03/27/2023

At present, there is limited information on animal models specific to ARHGEF25. However, general RhoGEF knockout or overexpression mouse models may provide insights into the function and regulation of ARHGEF25.

Is ARHGEF25 conserved across different species? 01/26/2023

ARHGEF25 shows a certain degree of conservation across different species, indicating its importance in cellular processes. Conserved regions within the protein provide insights into its functional domains and potential roles in various organisms.

Are there any known mutations in the ARHGEF25 gene associated with diseases? 11/17/2022

While there have been reported genetic variants in the ARHGEF25 gene, currently there is limited information regarding disease-associated mutations. Further studies are needed to determine the potential link between specific ARHGEF25 mutations and disease phenotypes.

Can ARHGEF25 be used as a biomarker for disease diagnosis or prognosis? 09/07/2022

ARHGEF25 has shown promise as a potential biomarker in certain cancers. High expression levels of ARHGEF25 have been associated with poor prognosis in colorectal cancer, gastric cancer, and breast cancer. However, additional research is needed to validate its potential as a diagnostic or prognostic biomarker in clinical settings.

Is ARHGEF25 involved in any other cellular processes besides cell migration? 08/15/2022

Yes, besides cell migration, ARHGEF25 has also been implicated in other cellular processes such as cell adhesion, cell proliferation, and actin cytoskeleton organization.

What are some specific diseases or conditions in which ARHGEF25 has been implicated? 02/12/2021

While the role of ARHGEF25 in certain diseases is still being investigated, it has been implicated in cancer progression and metastasis. Studies have shown that increased expression of ARHGEF25 is associated with poor prognosis in various cancers, including colorectal cancer, gastric cancer, and breast cancer. Additionally, ARHGEF25 has been linked to neurological disorders such as Alzheimer's disease, where it may play a role in neuronal dysfunction and synaptic plasticity.

How is ARHGEF25 involved in cell migration? 12/21/2020

ARHGEF25 promotes cell migration by activating Rac1, a protein involved in cytoskeletal rearrangement and formation of lamellipodia, which are required for cell movement.

Can ARHGEF25 be used as a diagnostic or prognostic marker? 08/24/2020

Currently, there is insufficient evidence to consider ARHGEF25 as a diagnostic or prognostic marker. However, ongoing research may uncover its potential utility in clinical applications in the future.

Are there any known genetic variations in the ARHGEF25 gene? 03/30/2020

Yes, there have been reported genetic variants in the ARHGEF25 gene in certain populations. These variations can potentially affect the protein's function and may be associated with disease susceptibility or altered cellular processes.

Can small molecules or drugs target ARHGEF25? 02/16/2020

As of now, there are no specific small molecule inhibitors or drugs known to target ARHGEF25. However, further investigation into its regulatory mechanisms may reveal potential therapeutic strategies in the future.

Are there any known natural compounds or dietary factors that modulate ARHGEF25 expression or activity? 04/24/2019

Currently, there is limited information regarding natural compounds or dietary factors that directly modulate ARHGEF25 expression or activity. Further research is needed to explore this aspect and identify potential natural modulators of ARHGEF25.

How can studying ARHGEF25 contribute to our understanding of diseases beyond cancer? 08/22/2018

Broadening our knowledge of ARHGEF25 can help in understanding its potential involvement in other diseases, such as neurological disorders, cardiovascular conditions, or immune-related disorders. Exploring its functions and interactions may shed light on novel therapeutic targets and pathways in these diseases.

Does ARHGEF25 interact with other proteins? 07/19/2018

Yes, ARHGEF25 can interact with various signaling molecules and effector proteins. For example, it has been shown to interact with p21-activated kinase (PAK), an important downstream effector of Rac1 signaling.

Can ARHGEF25 be used as a therapeutic target in combination with other drugs? 06/30/2018

Combining targeted therapies that inhibit ARHGEF25-associated pathways with existing drugs could potentially enhance their efficacy in treating certain diseases. However, more research is needed to identify specific therapeutic targets and evaluate the feasibility of combination therapies involving ARHGEF25.

Are there any ongoing clinical trials targeting ARHGEF25? 12/12/2017

As of now, there are no registered clinical trials specifically targeting ARHGEF25. However, given its involvement in cancer progression and metastasis, future studies may explore potential therapeutic strategies targeting ARHGEF25 or its related signaling pathways.

What signaling pathways are involved in the regulation of ARHGEF25? 08/20/2017

The regulation of ARHGEF25 can be influenced by several signaling pathways. For example, the Wnt/β-catenin signaling pathway has been shown to upregulate ARHGEF25 expression in certain cancer cell lines. Additionally, the MAPK/ERK pathway has also been implicated in the regulation of ARHGEF25 in cancer cells.

Does ARHGEF25 play a role in neuronal development? 07/28/2017

There is limited information on the role of ARHGEF25 in neuronal development. Most research on ARHGEF25 has focused on its involvement in cancer and cellular processes related to Rac1 signaling.

Are there any known inhibitors or activators of ARHGEF25? 12/09/2016

Currently, there are no specific inhibitors or activators of ARHGEF25. However, understanding its regulatory mechanisms and interactions might provide avenues for developing modulators of ARHGEF25 activity in the future.

How is ARHGEF25 expression regulated during development? 10/02/2016

The specific regulation of ARHGEF25 expression during development is not well understood. However, studies have shown that ARHGEF25 is expressed in various tissues during embryogenesis, suggesting its potential involvement in tissue morphogenesis and cellular differentiation.

Are there any diseases associated with ARHGEF25 mutations? 06/24/2016

Currently, there is limited information on ARHGEF25 mutations and associated diseases. Further research is needed to fully understand the implications of ARHGEF25 mutations in human health.

Customer Reviews (8)

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Reviews
06/22/2022

    Their responsiveness to inquiries and willingness to address concerns contribute to a smooth and productive research experience.

    04/09/2022

      Whether it is regarding experimental design, optimization of protocols, or troubleshooting issues, their expertise and prompt customer service help researchers overcome challenges efficiently.

      12/10/2021

        This reliable and punctual supply enables me to proceed with my experiments without unnecessary delays, ensuring an efficient research process.

        12/06/2021

          Securing a protein of exceptional quality is crucial to meet the demands of my experiments, and I am confident that the ARHGEF25 protein offered by the manufacturer will fulfill my requirements.

          08/03/2021

            heir responsiveness to inquiries and willingness to address concerns contribute to a smooth and productive research experience.

            04/03/2019

              the ARHGEF25 protein, combined with the manufacturer's outstanding technical support and commitment to delivering high-quality products, presents an excellent opportunity for my research.

              12/19/2016

                They provide comprehensive technical assistance and guidance throughout the entire research process.

                05/16/2016

                  Whether it's troubleshooting guidance, experimental design suggestions, or elucidating optimal storage conditions, their expertise can significantly accelerate the progress of my trials.

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