Recombinant Mouse ARHGEF25 Protein
Cat.No. : | ARHGEF25-1896M |
Product Overview : | Recombinant Mouse ARHGEF25 full length or partial length protein was expressed. |
- Specification
- Gene Information
- Related Products
Source : | Mammalian Cells |
Species : | Mouse |
Tag : | His |
Form : | Liquid or lyophilized powder |
Endotoxin : | < 1.0 EU per μg of the protein as determined by the LAL method. |
Purity : | >80% |
Notes : | This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications. |
Storage : | Store it at +4 ºC for short term. For long term storage, store it at -20 ºC~-80 ºC. |
Storage Buffer : | PBS buffer |
Gene Name : | Arhgef25 Rho guanine nucleotide exchange factor (GEF) 25 [ Mus musculus ] |
Official Symbol : | ARHGEF25 |
Gene ID : | 52666 |
mRNA Refseq : | NM_001166413.1 |
Protein Refseq : | NP_001159885.1 |
MIM : | |
UniProt ID : | Q9CWR0 |
Products Types
◆ Recombinant Protein | ||
ARHGEF25-2497H | Recombinant Human ARHGEF25 Protein, His (Fc)-Avi-tagged | +Inquiry |
ARHGEF25-696M | Recombinant Mouse ARHGEF25 Protein, His (Fc)-Avi-tagged | +Inquiry |
ARHGEF25-427R | Recombinant Rat ARHGEF25 Protein, His (Fc)-Avi-tagged | +Inquiry |
ARHGEF25-771R | Recombinant Rat ARHGEF25 Protein | +Inquiry |
ARHGEF25-975H | Recombinant Human ARHGEF25 | +Inquiry |
◆ Lysates | ||
ARHGEF25-5962HCL | Recombinant Human GEFT 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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- Q&As
- Reviews
Q&As (20)
Ask a questionAt present, there is limited information on animal models specific to ARHGEF25. However, general RhoGEF knockout or overexpression mouse models may provide insights into the function and regulation of ARHGEF25.
ARHGEF25 shows a certain degree of conservation across different species, indicating its importance in cellular processes. Conserved regions within the protein provide insights into its functional domains and potential roles in various organisms.
While there have been reported genetic variants in the ARHGEF25 gene, currently there is limited information regarding disease-associated mutations. Further studies are needed to determine the potential link between specific ARHGEF25 mutations and disease phenotypes.
ARHGEF25 has shown promise as a potential biomarker in certain cancers. High expression levels of ARHGEF25 have been associated with poor prognosis in colorectal cancer, gastric cancer, and breast cancer. However, additional research is needed to validate its potential as a diagnostic or prognostic biomarker in clinical settings.
Yes, besides cell migration, ARHGEF25 has also been implicated in other cellular processes such as cell adhesion, cell proliferation, and actin cytoskeleton organization.
While the role of ARHGEF25 in certain diseases is still being investigated, it has been implicated in cancer progression and metastasis. Studies have shown that increased expression of ARHGEF25 is associated with poor prognosis in various cancers, including colorectal cancer, gastric cancer, and breast cancer. Additionally, ARHGEF25 has been linked to neurological disorders such as Alzheimer's disease, where it may play a role in neuronal dysfunction and synaptic plasticity.
ARHGEF25 promotes cell migration by activating Rac1, a protein involved in cytoskeletal rearrangement and formation of lamellipodia, which are required for cell movement.
Currently, there is insufficient evidence to consider ARHGEF25 as a diagnostic or prognostic marker. However, ongoing research may uncover its potential utility in clinical applications in the future.
Yes, there have been reported genetic variants in the ARHGEF25 gene in certain populations. These variations can potentially affect the protein's function and may be associated with disease susceptibility or altered cellular processes.
As of now, there are no specific small molecule inhibitors or drugs known to target ARHGEF25. However, further investigation into its regulatory mechanisms may reveal potential therapeutic strategies in the future.
Currently, there is limited information regarding natural compounds or dietary factors that directly modulate ARHGEF25 expression or activity. Further research is needed to explore this aspect and identify potential natural modulators of ARHGEF25.
Broadening our knowledge of ARHGEF25 can help in understanding its potential involvement in other diseases, such as neurological disorders, cardiovascular conditions, or immune-related disorders. Exploring its functions and interactions may shed light on novel therapeutic targets and pathways in these diseases.
Yes, ARHGEF25 can interact with various signaling molecules and effector proteins. For example, it has been shown to interact with p21-activated kinase (PAK), an important downstream effector of Rac1 signaling.
Combining targeted therapies that inhibit ARHGEF25-associated pathways with existing drugs could potentially enhance their efficacy in treating certain diseases. However, more research is needed to identify specific therapeutic targets and evaluate the feasibility of combination therapies involving ARHGEF25.
As of now, there are no registered clinical trials specifically targeting ARHGEF25. However, given its involvement in cancer progression and metastasis, future studies may explore potential therapeutic strategies targeting ARHGEF25 or its related signaling pathways.
The regulation of ARHGEF25 can be influenced by several signaling pathways. For example, the Wnt/β-catenin signaling pathway has been shown to upregulate ARHGEF25 expression in certain cancer cell lines. Additionally, the MAPK/ERK pathway has also been implicated in the regulation of ARHGEF25 in cancer cells.
There is limited information on the role of ARHGEF25 in neuronal development. Most research on ARHGEF25 has focused on its involvement in cancer and cellular processes related to Rac1 signaling.
Currently, there are no specific inhibitors or activators of ARHGEF25. However, understanding its regulatory mechanisms and interactions might provide avenues for developing modulators of ARHGEF25 activity in the future.
The specific regulation of ARHGEF25 expression during development is not well understood. However, studies have shown that ARHGEF25 is expressed in various tissues during embryogenesis, suggesting its potential involvement in tissue morphogenesis and cellular differentiation.
Currently, there is limited information on ARHGEF25 mutations and associated diseases. Further research is needed to fully understand the implications of ARHGEF25 mutations in human health.
Customer Reviews (8)
Write a reviewTheir responsiveness to inquiries and willingness to address concerns contribute to a smooth and productive research experience.
Whether it is regarding experimental design, optimization of protocols, or troubleshooting issues, their expertise and prompt customer service help researchers overcome challenges efficiently.
This reliable and punctual supply enables me to proceed with my experiments without unnecessary delays, ensuring an efficient research process.
Securing a protein of exceptional quality is crucial to meet the demands of my experiments, and I am confident that the ARHGEF25 protein offered by the manufacturer will fulfill my requirements.
heir responsiveness to inquiries and willingness to address concerns contribute to a smooth and productive research experience.
the ARHGEF25 protein, combined with the manufacturer's outstanding technical support and commitment to delivering high-quality products, presents an excellent opportunity for my research.
They provide comprehensive technical assistance and guidance throughout the entire research process.
Whether it's troubleshooting guidance, experimental design suggestions, or elucidating optimal storage conditions, their expertise can significantly accelerate the progress of my trials.
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