ARHGEF6 Protein, Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6

ARHGEF6

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ARHGEF6

Official Full Name Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
Background Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein is activated by PI3-kinase. Mutations in this gene can cause X-chromosomal non-specific mental retardation.
Synonyms ARHGEF6; Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6; mental retardation, X linked 46 , MRX46; rho guanine nucleotide exchange factor 6; alpha PIX; alphaPIX; Cool 2; Cool2; KIAA0006; PAK interacting exchange factor; alpha; Rac/Cdc42 guanine exchange factor (GEF) 6; Mental retardation, X linked 46; MRX46; PAK interacting exchange factor alpha; PIXA; Rac/cdc42 guanine nucleotide exchange factor 6; PAK-interacting exchange factor alpha; PAK-interacting exchange factor, alpha; Cool-2; alpha-PIX
    • Species :
    • Chicken
    • Human
    • Rat
    • Rhesus Macaque
    • Source :
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ARHGEF6-119HCL Recombinant Human ARHGEF6 cell lysate N/A
    Human ARHGEF6-789H Recombinant Human ARHGEF6 protein, GST-tagged Wheat Germ GST
    Rat ARHGEF6-773R Recombinant Rat ARHGEF6 Protein Mammalian Cell His
    Rhesus Macaque ARHGEF6-395R Recombinant Rhesus monkey ARHGEF6 Protein, His-tagged Mammalian Cell His
    Chicken ARHGEF6-1573C Recombinant Chicken ARHGEF6 Mammalian Cell His

    ARHGEF6 involved in several pathways and played different roles in them. We selected most pathways ARHGEF6 participated on our site, such as Regulation of actin cytoskeleton, Pancreatic cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARHGEF6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Regulation of actin cytoskeleton PDGFC; ITGB3; MYL9A; MAPK1; RHOA; FGF12; LIMK1A; PFN1; FGFR1A; PFN3
    Pancreatic cancer BRCA2; PIK3CD; RELA; PIK3CA; PIK3R5; PIK3CB; RALB; CASP9; RAD51; AKT2

    ARHGEF6 has several biochemical functions, for example, GTPase activator activity, Rho guanyl-nucleotide exchange factor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARHGEF6 itself. We selected most functions ARHGEF6 had, and list some proteins which have the same functions with ARHGEF6. You can find most of the proteins on our site.

    Function Related Protein
    GTPase activator activity TBC1D3; ARHGAP40; BNIP2; RASAL3; CDC42EP4A; TBC1D17; TBC1D24; RIC8B; FAM13B1; RGS14
    Rho guanyl-nucleotide exchange factor activity RASGRF2; FGD; ARHGEF7A; FGD4A; DOCK9; ARHGEF9B; NET1; ITSN1; ARHGEF39; PLEKHG5
    protein binding CSK; SEC22B; EFCAB4A; STON2; RAD50; FAM9B; ARHGEF3; TRIM16; TMEM182; BAG2

    ARHGEF6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARHGEF6 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARHGEF6.

    PAK1; NAA10; PAK2; SH2D1A; CDC42; MDM2; ADAM15; nef; TMEM108; GPRASP2; SH3GL3; ZNF580; q9wmx2-pro_0000037548; GIT1; ARRB2

    Estrach, S; Schmidt, S; et al. The human Rho-GEF trio and its target GTPase RhoG are involved in the NGF pathway, leading to neurite outgrowth. CURRENT BIOLOGY 12:307-312(2002).

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