Recombinant Human ARHGEF6 protein, GST-tagged

• Cat.No.: ARHGEF6-789H
• Product Overview: Human ARHGEF6 full-length ORF ( NP_004831.1, 1 a.a. - 776 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein is activated by PI3-kinase. Mutations in this gene can cause X-chromosomal non-specific mental retardation. [provided by RefSeq, Jul 2008]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 113.9 kDa
• AA Sequence: MNPEEQIVTWLISLGVLESPKKTIC DPEEFLKSSLKNGVVLCKLINRLMP GSVEKFCLDPQTEADCINNINDFLK GCATLQVEIFDPDDLYSGVNFSKVL STLLAVNKATEDQLSERPCGRSSSL SAANTSQTNPQGAVSSTVSGLQRQS KTVEMTENGSHQLIVKARFNFKQTN EDELSVCKGDIIYVTRVEEGGWWEG TLNGRTGWFPSNYVREIKSSERPLS PKAVKGFETAPLTKNYYTVVLQNIL DTEKEYAKELQSLLVTYLRPLQSNN NLSTVEVTSLLGNFEEVCTFQQTLC QALEECSKFPENQHKVGGCLLSLMP HFKSMYLAYCANHPSAVNVLTQHSD ELEQFMENQGASSPGILILTTNLSK PFMRLEKYVTLLQELERHMEDTHPD HQDILKAIVAFKTLMGQCQDLRKRK QLELQILSEPIQAWEGEDIKNLGNV IFMSQVMVQYGACEEKEERYLMLFS NVLIMLSASPRMSGFIYQGKIPIAG TVVTRLDEIEGNDCTFEITGNTVER IVVHCNNNQDFQEWLEQLNRLIRGP ASCSSLSKTSSSSCSAHSSFSSTGQ PRGPLEPPQIIKPWSLSCLRPAPPL RPSAALGYKERMSYILKESSKSPKT MKKFLHKRKTERKPSEEEYVIRKST AALEEDAQILKVIEAYCTSANFQQG HGSSTRKDSIPQVLLPEEEKLIIEE TRSNGQTIMEEKSLVDTVYALKDEV RELKQENKRMKQCLEEELKSRRDLE KLVRRLLKQTDECIRGESSSKTSIL P
• Applications: Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 [ Homo sapiens ]
• Official Symbol: ARHGEF6
• Synonyms: ARHGEF6; Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6; mental retardation, X linked 46 , MRX46; rho guanine nucleotide exchange factor 6; alpha PIX; alphaPIX; Cool 2; Cool2; KIAA0006; PAK interacting exchange factor; alpha; Rac/Cdc42 guanine exchange factor (GEF) 6; PAK-interacting exchange factor alpha; PAK-interacting exchange factor, alpha; rac/Cdc42 guanine nucleotide exchange factor 6; PIXA; COOL2; MRX46; Cool-2; alpha-PIX
• Gene ID: 9459
• mRNA Refseq: NM_004840
• Protein Refseq: NP_004831
• MIM: 300267
• UniProt ID: Q15052