ARNTL
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Official Full Name
aryl hydrocarbon receptor nuclear translocator-like -
Overview
ARNTL-CLOCK heterodimers activate E-box element (5-CACGTG-3) transcription of a number of proteins of the circadian clock. This transcription is inhibited in a feedback loop by PER, and also by CRY proteins. -
Synonyms
ARNTL;aryl hydrocarbon receptor nuclear translocator-like;aryl hydrocarbon receptor nuclear translocator-like protein 1;ARNT like protein 1 brain and muscle;Arntl;Aryl hydrocarbon receptor nuclear translocator like;Aryl hydrocarbon receptor nuclear translocator like protein 1;Aryl hydrocarbon receptor nuclear translocator-like protein 1;Basic helix loop helix PAS orphan MOP3;Basic helix loop helix PAS protein MOP3;Basic-helix-loop-helix-PAS protein MOP3;bHLH PAS protein JAP3;bHLH-PAS protein JAP3;bHLHe5;BMAL 1;BMAL1;BMAL1c;Brain and muscle ARNT like 1;Brain and muscle ARNT-like 1;CG8727 PA;Class E basic helix-loop-helix protein 5;cycle;JAP 3;JAP3;Member of PAS protein 3;Member of PAS superfamily 3;MOP 3;MOP3;PAS domain-containing protein 3;PASD 3;PASD3;TIC;bHLH-PAS protein JAP3;member of PAS protein 3;member of PAS superfamily 3;brain and muscle ARNT-li;TIC;JAP3;MOP3;BMAL1;PASD3;BMAL1c;bHLHe5
Recombinant Proteins
- Human
- Chicken
- Rhesus macaque
- Rat
- Mouse
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- T7
- GST
- Non
- DDK
- Myc
- Avi
- Fc
Involved Pathway
ARNTL involved in several pathways and played different roles in them. We selected most pathways ARNTL participated on our site, such as Circadian rhythm,Dopaminergic synapse,Herpes simplex infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARNTL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Dopaminergic synapse | KCNJ5,DRD1A,GNG3,GNAO1,CALM2,GNG2,SCN1A,MAPK12,CREB3L3,PPP1CA |
| Circadian rhythm | NPAS2,PER3,CLOCK,PRKAG1,SKP1,CRY2,PRKAB2,RORC,CUL1,BTRC |
| Herpes simplex infection | IFNPHI1,EEF1D,PER1A,DDX58,STAT1B,PTPN11B,IRF3,HLA-G,TAP1,TBPL1 |
Protein Function
ARNTL has several biochemical functions, for example, DNA binding,E-box binding,Hsp90 protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARNTL itself. We selected most functions ARNTL had, and list some proteins which have the same functions with ARNTL. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein dimerization activity | SREBF2,MEF2CB,MESPBA,PTF1A,ASCL1A,MYCH,MYCL1,SMG1,MEF2B,SIM1A |
| repressing transcription factor binding | HDAC1,NOC2L,CBX5,HHEX,SKI,MAGEA2,HMGB1,HDAC7,CTNNB1,EIF4E |
| DNA binding | EZH2,CDK9,ZNF511,LMX1BB,MEF2CB,PCGF2,ZFPM2,PHOX2BA,FOXM1,SMG6 |
| core promoter binding | MYBBP1A,SAFB,INSM1A,KDM3A,E2F3,ELK1,MYOD1,SFPQ,CLOCK,HDAC6 |
| transcription regulatory region sequence-specific DNA binding | KDM3A,CRY2,NR5A2,HIF1AL,BTBD8,NFKB1,NR5A1A,ARNTL1A,NFE2L1A,ATF3 |
| sequence-specific DNA binding | RXRAA,POU3F3B,TFCP2,BSX,GZF1,BHLHE22,HOXB6A,ZFP191,RX1,FOXA3 |
| transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding | FOSL1A,DDN,RBPJA,RBPJL,FOSB,SREBF1,ATF3,IRF7,FOS,FOSL1 |
| Hsp90 protein binding | CSNK2A1,STUB1,PPEF2,EIF2AK3,ERBB2,RPS3,PACRG,UNC45B,UNC45A,NASP |
| E-box binding | BHLHE40,TCF21,GATA3,NEUROD2,ASCL1,MYOG,LMO2,SREBF2,TFAP4,AHR |
Interacting Protein
ARNTL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARNTL here. Most of them are supplied by our site. Hope this information will be useful for your research of ARNTL.
HIF1A;CLOCK;EPAS1;DYRK1B
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