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Recombinant Human ARNTL protein, GST-tagged

Cat.No. : ARNTL-842H
Product Overview : Human ARNTL full-length ORF ( AAH41129, 1 a.a. - 625 a.a.) recombinant protein with GST-tag at N-terminal.
  • Specification
  • Gene Information
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Description : The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This heterodimer binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 94.49 kDa
AA Sequence : MADQRMDISSTISDFMSPGPTDLLS SSLGTSGVDCNRKRKGSSTDYQESM DTDKDDPHGRLEYTEHQGRIKNARE AHSQIEKRRRDKMNSFIDELASLVP TCNAMSRKLDKLTVLRMAVQHMKTL RGATNPYTEANYKPTFLSDDELKHL ILRAADGFLFVVGCDRGKILFVSES VFKILNYSQNDLIGQSLFDYLHPKD IAKVKEQLSSSDTAPRERLIDAKTG LPVKTDITPGPSRLCSGARRSFFCR MKCNRPSVKVEDKDFPSTCSKKKDR KSFCTIHSTGYLKSWPPTKMGLDED NEPDNEGCNLSCLVAIGRLHSHVVP QPVNGEIRVKSMEYVSRHAIDGKFV FVDQRATAILAYLPQELLGTSCYEY FHQDDIGHLAECHRQVLQTREKITT NCYKFKIKDGSFITLRSRWFSFMNP WTKEVEYIVSTNTVVLANVLEGGDP TFPQLTASPHSMDSMLPSGEGGPKR THPTVPGIPGGTRAGAGKIGRMIAE EIMEIHRIRGSSPSSCGSSPLNITS TPPPDASSPGGKKILNGGTPDIPSS GLLSGQAQENPGYPYSDSSSILGEN PHIGIDMIDNDQGSSSPSNDEAAMA VIMSLLEADAGLGGPVDFSDLPWPL
Applications : Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : ARNTL aryl hydrocarbon receptor nuclear translocator-like [ Homo sapiens ]
Official Symbol : ARNTL
Synonyms : ARNTL; aryl hydrocarbon receptor nuclear translocator-like; aryl hydrocarbon receptor nuclear translocator-like protein 1; bHLHe5; BMAL1; JAP3; MOP3; PASD3; bHLH-PAS protein JAP3; member of PAS protein 3; member of PAS superfamily 3; brain and muscle ARNT-like 1; PAS domain-containing protein 3; ARNT-like protein 1, brain and muscle; basic-helix-loop-helix-PAS orphan MOP3; basic-helix-loop-helix-PAS protein MOP3; class E basic helix-loop-helix protein 5; TIC; BMAL1c; MGC47515;
Gene ID : 406
mRNA Refseq : NM_001030272
Protein Refseq : NP_001025443
MIM : 602550
UniProt ID : O00327

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (23)

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Can the ARNTL protein be targeted for drug development? 06/01/2022

Targeting the ARNTL protein could potentially be a viable approach for drug development to manage circadian rhythm disorders or conditions with disrupted circadian rhythms. By modulating ARNTL's activity or stability, it might be possible to restore normal circadian rhythms and alleviate associated symptoms.

Can environmental factors, such as shift work or jet lag, affect ARNTL expression? 06/03/2021

Yes, environmental factors can disrupt the expression of ARNTL and the overall regulation of circadian rhythms. Shift work, irregular sleep patterns, and rapid time zone changes (jet lag) can all disrupt the synchronization of the circadian clock, potentially affecting ARNTL expression and leading to adverse health consequences.

Are there any animal models available to study ARNTL? 05/08/2021

Yes, animal models, particularly mice, have been widely used to study the function of ARNTL. Knockout mice lacking ARNTL display disrupted circadian rhythms and exhibit physiological and behavioral abnormalities, providing valuable insights into the protein's role.

Are there any genetic disorders associated with mutations in the ARNTL gene? 02/08/2021

Yes, mutations in the ARNTL gene have been linked to familial advanced sleep phase syndrome (FASPS). FASPS causes individuals to experience an earlier onset of sleep and wake times, disrupting their daily sleep-wake cycle. These mutations can affect the normal functioning of the circadian clock regulated by ARNTL.

Are there any known genetic variations in the ARNTL gene that affect its function? 12/13/2020

Yes, there are genetic variations in the ARNTL gene that have been associated with altered circadian rhythms and sleep disorders. For example, mutations or polymorphisms in ARNTL have been linked to familial advanced sleep phase syndrome (FASPS) and delayed sleep phase disorder (DSPD). These variations can affect ARNTL's stability, transcriptional activity, or interaction with other proteins.

Is ARNTL expression influenced by age? 07/27/2020

Yes, studies have suggested that ARNTL expression can be influenced by age. There is evidence indicating age-related changes in the circadian clock system, including alterations in the expression pattern of ARNTL. These age-related changes in ARNTL expression may contribute to age-related sleep and circadian rhythm disturbances.

How does ARNTL regulate the expression of clock genes? 12/16/2019

ARNTL forms a heterodimer with CLOCK protein or NPAS2, and together they bind to E-box regulatory elements in the promoter regions of clock genes. This binding activates the expression of clock genes, which are essential for maintaining circadian rhythms.

Can lifestyle factors, such as sleep patterns and meal timing, affect ARNTL expression? 12/11/2019

Yes, lifestyle factors can affect ARNTL expression. Regular sleep patterns and consistent meal timing have been shown to help maintain normal circadian rhythms and support healthy ARNTL expression. Disruptions in sleep or irregular meal patterns can lead to dysregulation of ARNTL and circadian rhythms.

Can the ARNTL protein interact with other transcription factors? 08/21/2019

Yes, the ARNTL protein can interact with other transcription factors, such as CLOCK, NPAS2, and RORα, to form heterodimers. These interactions are essential for the activation of clock genes and the regulation of circadian rhythms.

Can ARNTL be regulated by non-circadian factors? 06/22/2019

Yes, ARNTL can be regulated by non-circadian factors as well. For example, it can be influenced by hormonal signals, such as glucocorticoids, which play a role in circadian rhythm regulation. Additionally, signaling pathways involved in cellular metabolism and stress response can also affect ARNTL expression and activity.

Are there any ongoing research efforts to study ARNTL? 06/20/2019

Yes, there are ongoing research efforts to further understand the functions and mechanisms of ARNTL. Scientists are investigating its role in various biological processes, exploring its interactions with other proteins, and studying its potential therapeutic implications for circadian rhythm disorders and related conditions.

Is ARNTL involved in the regulation of other biological processes besides circadian rhythms? 06/12/2019

While ARNTL's main function is to regulate circadian rhythms, it has been implicated in other biological processes. Studies suggest that ARNTL may be involved in metabolism, immune system regulation, cell proliferation, and even cancer development. However, further research is needed to fully understand the extent of its involvement in these processes.

Does the ARNTL protein have any roles outside of circadian rhythm regulation? 05/12/2019

While the primary role of the ARNTL protein is in circadian rhythm regulation, emerging research suggests that it may have additional functions. ARNTL has been implicated in metabolism, immune responses, and neuronal plasticity, although further investigations are needed to fully understand these roles.

Does ARNTL expression differ between different tissues and cell types? 02/25/2019

Yes, ARNTL expression can vary between different tissues and cell types. While it is predominantly expressed in the central circadian pacemaker, the SCN, it is also present in peripheral tissues. The expression levels and patterns of ARNTL can differ depending on the tissue or cell type, reflecting the tissue-specific functions and regulation of the circadian clock.

Is ARNTL involved in other biological processes besides circadian rhythms? 07/21/2018

Yes, ARNTL is involved in other biological processes besides circadian rhythms. It plays a role in regulating metabolism, immune response, cell proliferation, and development, among others. The function of ARNTL extends beyond circadian rhythm regulation and involves interactions with various signaling pathways.

Are there any known drugs or compounds that target ARNTL for therapeutic purposes? 01/15/2018

Currently, there are no drugs specifically targeting ARNTL for therapeutic purposes. However, research is ongoing to explore potential pharmacological interventions that can modulate ARNTL's activity or stability for the management of circadian rhythm disorders and related conditions.

Is ARNTL involved in the regulation of reproductive processes? 12/27/2017

Yes, ARNTL is involved in the regulation of reproductive processes. It can influence the activity of the hypothalamic-pituitary-gonadal axis, which controls reproductive hormone release and fertility. Perturbations in ARNTL can affect reproductive hormone secretion and disrupt reproductive processes.

Can ARNTL be targeted for therapeutic interventions? 10/07/2017

ARNTL represents a potential target for therapeutic interventions related to circadian rhythm disorders or conditions influenced by circadian dysregulation. Modulating the activity or expression of ARNTL could potentially restore or normalize circadian rhythms in individuals with sleep disorders or other related conditions.

Which tissues or organs primarily express the ARNTL protein? 08/10/2017

ARNTL is expressed in a wide range of tissues and organs, including the brain, liver, heart, and skeletal muscle. Its expression is particularly prominent in areas of the brain associated with circadian rhythm regulation, such as the suprachiasmatic nucleus (SCN).

How does ARNTL influence the expression of clock genes? 05/09/2017

ARNTL, along with its partner proteins, forms transcriptional complexes that bind to specific DNA sequences called E-boxes in the promoters of clock genes. This binding activates the transcription of clock genes, such as Period (PER) and Cryptochrome (CRY), leading to the production of their respective proteins. These proteins then feed back and inhibit their own transcription, creating a negative feedback loop that regulates the circadian clock.

Are there any known interactions between ARNTL and other proteins involved in circadian rhythm regulation? 04/11/2017

Yes, ARNTL interacts with various proteins involved in circadian rhythm regulation. These include CLOCK, NPAS2, PER (Period), and CRY (Cryptochrome) proteins. These interactions are crucial for the formation of functional complexes that drive the expression of clock genes and the proper functioning of the circadian clock.

Are there any diseases or disorders associated with dysregulation of the ARNTL protein? 05/24/2016

Dysregulation or mutations in ARNTL can contribute to various disorders. Apart from familial advanced sleep phase syndrome (FASPS), disruptions in ARNTL have been associated with sleep disorders, mood disorders, metabolic disorders, and even certain types of cancers. However, the exact mechanisms and contributions of ARNTL dysregulation to these conditions are still being investigated.

Does ARNTL play a role in the regulation of seasonal rhythms? 05/23/2016

Yes, ARNTL has been implicated in the regulation of seasonal rhythms in certain species. It has been observed that ARNTL expression can vary depending on the seasonal changes in day length, enabling animals to adapt their physiological and behavioral processes to the changing seasons.

Customer Reviews (6)

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Reviews
11/20/2022

    The ARNTL protein stands out as a protein of exceptional quality, perfectly suited to meet the experimental needs of researchers.

    04/01/2021

      This cutting-edge technique allows for the visualization and characterization of protein structures at the atomic level, providing insights into their function and potential therapeutic targets.

      01/27/2021

        The knowledgeable and responsive support team offers valuable assistance and expertise, making troubleshooting and problem-solving much more efficient.

        04/21/2020

          Whether utilized in protein-protein interaction studies or enzymatic assays, this protein exhibits robust performance, enabling accurate data generation and analysis.

          09/21/2016

            the ARNTL protein not only fulfills my experimental requirements but is also backed by excellent technical support, which guarantees a smooth and successful research experience.

            02/04/2016

              By using the ARNTL protein in my experiments, I am confident in obtaining accurate and dependable data.

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