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ATP12A

Official Full Name

ATPase, H+/K+ transporting, nongastric, alpha polypeptide
Overview

The protein encoded by this gene belongs to the family of P-type cation transport ATPases. This gene encodes a catalytic subunit of the ouabain-sensitive H+/K+ -ATPase that catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. It is also responsible for potassium absorption in various tissues. Two transcript variants encoding different isoforms have been found for this gene.
Synonyms

ATP12A; ATPase, H+/K+ transporting, nongastric, alpha polypeptide; ATP1AL1, ATPase, Na+/K+ transporting, alpha polypeptide like 1; potassium-transporting ATPase alpha chain 2; ATPase; Na+K+ transporting; alpha 1 polypeptide like; non gastric H(+)/K(+) ATPase alpha subunit; potassium transporting ATPase alpha chain 2; proton pump; sodium/potassium ATPase; alpha polypeptide like; ATP1AL1; ATPase H+/K+ transporting nongastric alpha polypeptide; ATPase Na+K+ transporting alpha-1 polypeptide-like; Hydrogen/potassium-exchanging ATPase 12A; Non-gastric H(+)/K(+) ATPase subunit alpha; Sodium/potassium ATPase alpha polypeptide-like; non-gastric H(+)/K(+) ATPase alpha subunit; ATPase, Na+/K+ transporting, alpha polypeptide-like 1;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Rat

Source

E.coli
HEK293
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	ATP12A-961H	Recombinant Human ATP12A protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	ATP12A-8614HCL	Recombinant Human ATP12A 293 Cell Lysate	HEK293	N/A		Inquiry
Human	ATP12A-263H	Recombinant Human ATP12A Protein, His-tagged	E.coli	N-His	Met1-Pro102	Inquiry
Mouse	ATP12A-2107M	Recombinant Mouse ATP12A Protein	Mammalian Cell	His		Inquiry
Mouse	ATP12A-844M	Recombinant Mouse ATP12A Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	ATP12A-844M-B	Recombinant Mouse ATP12A Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	ATP12A-851R	Recombinant Rat ATP12A Protein	Mammalian Cell	His		Inquiry
Rat	ATP12A-507R	Recombinant Rat ATP12A Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	ATP12A-507R-B	Recombinant Rat ATP12A Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Chicken	ATP12A-2598C	Recombinant Chicken ATP12A	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

ATP12A involved in several pathways and played different roles in them. We selected most pathways ATP12A participated on our site, such as Oxidative phosphorylation, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP12A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Oxidative phosphorylation	NDUFA8;ATP5G1;PPA1B;ATP5F1;MT-ATP6;NDUFS8B;UQCRH;ATP6AP2;NDUFB7

ATP12A has several biochemical functions, for example, ATP binding, hydrogen:potassium-exchanging ATPase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP12A itself. We selected most functions ATP12A had, and list some proteins which have the same functions with ATP12A. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	MYO1A;APAF1;AURKC;AURKA;P2RX2;ATP1A3B;PAPSS2A;HSP90AA1.1;NIM1K
hydrogen:potassium-exchanging ATPase activity	ATP4B;ATP6V1E1B;ATP4A;ATP12A
metal ion binding	TIMM8B;PPARG;ZDHHC16;FBXO30B;LIMK1A;CLIP1;RFK;ADAP2;ZNF671
sodium:potassium-exchanging ATPase activity	ATP1A3A;ATP1A2;ATP1B2;ATP1A2A;ATP1A3;ATP1A3B;ATP1A1A.4;ATP1A4;ATP1B3

ATP12A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP12A here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP12A.

NPY; GNAI3; PPIB; MME