atp1a1
Share
  • Official Full Name
  • ATPase, Na+/K+ transporting, alpha 1 polypeptide
  • Background
  • This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
  • Synonyms
  • ATP1A1; ATPase, Na+/K+ transporting, alpha 1 polypeptide; sodium/potassium-transporting ATPase subunit alpha-1; sodium pump 1; Na+/K+ ATPase 1; Na,K-ATPase alpha-1 subunit; sodium pump subunit alpha-1; Na+, K+ ATPase alpha subunit; Na(+)/K(+) ATPase alpha
Cat.#:ATP1A1-460HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ATP1A1 Protein, His-tagged
+Inquiry
Cat.#:ATP1A1-461RTag:His
Source (Host):E. coliSpecies:Rabbit
Product nameRecombinant Rabbit ATP1A1 Protein, His-tagged
+Inquiry
Cat.#:ATP1A1-10004HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ATP1A1, His-tagged
+Inquiry
Cat.#:ATP1A1-102HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ATP1A1 protein
+Inquiry
Cat.#:ATP1A1-293HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human ATP1A1 protein, MYC/DDK-tagged
+Inquiry
Cat.#:ATP1A1-2113MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ATP1A1 Protein
+Inquiry
Cat.#:ATP1A1-852RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat ATP1A1 Protein
+Inquiry
Cat.#:ATP1A1-446RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey ATP1A1 Protein, His-tagged
+Inquiry
Cat.#:ATP1A1-7070CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ATP1A1
+Inquiry
Cat.#:ATP1A1-8613HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human ATP1A1 293 Cell Lysate
+Inquiry

Involved Pathway

ATP1A1 involved in several pathways and played different roles in them. We selected most pathways ATP1A1 participated on our site, such as cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP1A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
cGMP-PKG signaling pathway
PIK3CA; SLC8A1; CALM3; ATP1A2; NPR2; PDE2A; CALM1; AKT2; INSR; SRF
cAMP signaling pathway
PIK3CA; NPY1R; RAC3; CAMK2G; GLI3; ATP1B4; PLD1; ACOX3; PIK3CB; FSHR
Cardiac muscle contraction
COX8A; ACTC1; MYH15; COX7A2L; ATP1B4; COX6A2; UQCRC2B; CACNB3; ATP1A3B; TPM1
Adrenergic signaling in cardiomyocytes
ADCY6; FXYD2; CACNB4; PLCB4; PRKCA; AGTR1; ATP1A1A.1; MAPK12; PPP2R5B; PPP2R5CB
Insulin secretion
KCNMB4; KCNMB3; GPR119; ADCYAP1; KCNJ11; GNA11; RIMS2; CAMK2B; CREB3L2; GNAS
Thyroid hormone synthesis
ATP1A3; ATP1B3; TTF2; TSHB; IYD; GPX5; TSHR; PLCB1; GPX2; ATP1A1
Thyroid hormone signaling pathway
GATA4; MED30; HIF1A; PIK3R1; PLCD1; PRKCG; PLCB4; NOTCH1; KAT2A; PLCZ1
Aldosterone-regulated sodium reabsorption
KCNJ1; MAPK3; ATP1B2; INS2; SCNN1B; PIK3R3; PIK3CB; ATP1B3; KRAS; IGF1
Endocrine and other factor-regulated calcium reabsorption
KLK1B1; ATP1B3; PRKACB; ATP1A2; KLK1B24; PRKCB; VDR; KLK1B22; KLK1B9; KLK1B3
Proximal tubule bicarbonate reclamation
SLC9A3; Car4; Car2; GLUD1; PCK2; GLS2; FXYD2; ATP1A4; ATP1B4; ATP1B1
Salivary secretion
BEST2; ITPR3; SLC9A1; CAMP; LYZ1; CALM3; CALML3; PRKCA; PRH2; ATP1B1
Gastric acid secretion
PLCB3; Slc4a2; Car2; SSTR2; Adcy4; ATP4B; GNAI3; SST; CAMK2A; GNAI1
Pancreatic secretion
PRKCA; CLCA2; CLCA4; AMY2A; SLC4A4; PNLIPRP1; ATP1B1; ATP1A2; PLA2G2D; KCNMA1
Carbohydrate digestion and absorption
PIK3R1; G6PC3; GNAT3; SI; ATP1B3; SLC5A1; PIK3CB; AKT2; G6PC2; SLC2A5
Protein digestion and absorption
CPA1; CTRL; CELA3A; COL10A1; SLC9A3; COL15A1; ATP1A2; PRSS1; KCNN4; MME
Bile secretion
ABCB11; SLC5A1; ATP1A3; ABCB4; HMGCR; GNAS; ABCG2; ADCY3; ATP1B4; CFTR
Mineral absorption
FTL; MT1F; S100G; CYBRD1; SLC34A2; SLC8A1; VDR; FTH1; TF; HEPH

Protein Function

ATP1A1 has several biochemical functions, for example, ADP binding, ATP binding, ankyrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP1A1 itself. We selected most functions ATP1A1 had, and list some proteins which have the same functions with ATP1A1. You can find most of the proteins on our site.
Function
Related Protein
Function ADP binding
Related Protein ADCK3; ACTA1; ME1; CYB5R3; PRPS1; PRPS2; MIEF1; PRKAG2; GLUD2; MYH9
Function ATP binding
Related Protein UBE2KB; OPLAH; UBE2D2; PBK; UBE2W; CLCN4; PDGFRB; MYH7B; BSK146; STK32A
Function ankyrin binding
Related Protein PTBP3; RHCG; CDH1; KCTD6; PLEC; NRCAM; SCN5A; RHAG; RHBG; SPTBN1
Function chaperone binding
Related Protein HSPD1; TIMM10; USP13; PRNP; ST13; SYVN1; DNAJB4; AHSA1; HES1; TBCC
Function phosphatase activity
Related Protein CDC14AA; PTPN11B; CTDNEP1; PTPN23A; CTDNEP1B; CTDSPLA; CDC14AB; PTPRDB; SACM1L; DUSP23A
Function phosphatidylinositol 3-kinase binding
Related Protein INSRR; TYRO3; PIK3R1; ATP1A1; CALM1; IGF1RB; IRS2; CALM2; IRS1; INSRA
Function potassium ion binding
Related Protein SLC24A5; PKM2; PKM; SLC24A1; ATP1A1; PKMB; HDAC4; PKMA; SLC24A2; KCNJ11
Function protein binding
Related Protein SR140; STX8; FKBP6; JAG1; OSTA; QKI; CHN1; FAM193B; ABCG8; GP5
Function protein domain specific binding
Related Protein MPP5; HMGB2; IL1B; HIST1H4C; LIN7C; STRN4; HIST1H4J; GABRR3; POU2F2; YWHAE1
Function protein kinase binding
Related Protein TP53; CLTC; PDCD10; PRKAG3; TICAM1; EEF1A1; EMP2; PTPN23; RPS19; EPHA1
Function sodium ion binding
Related Protein SLC24A4A; SCN9A; SLC24A1; SLC34A2; SLC24A2; ATP1A1; SLC24A5; PDXK; CAPN3; SLC24A4
Function sodium:potassium-exchanging ATPase activity
Related Protein ATP1A1A.4; ATP1A1A.3; ATP1A1B; ATP1A3B; ATP1A1A.2; ATP1B3; ATP1A2A; ATP12A; ATP1A1A.1; FXYD2
Function contributes_to sodium:potassium-exchanging ATPase activity
Related Protein ATP1B1; ATP1B2; ATP1B3; ATP1A1; ATP1A2
Function steroid hormone binding
Related Protein ESR2B; ATP1A2; ATP1A1; ESR2A; NR3C1; ATP1A3; GPR30

Interacting Protein

ATP1A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP1A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP1A1.
TPT1; ERBB2; GTF2F2; TNFRSF1A; TNFRSF1B; Tpt1; TRADD; SMAD2; NDRG1; SNX6; SNAPIN; EZH2; 15-deoxy-delta(12,14