atp1a1
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  • Official Full Name
  • ATPase, Na+/K+ transporting, alpha 1 polypeptide
  • Background
  • This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
  • Synonyms
  • ATP1A1; ATPase, Na+/K+ transporting, alpha 1 polypeptide; sodium/potassium-transporting ATPase subunit alpha-1; sodium pump 1; Na+/K+ ATPase 1; Na,K-ATPase alpha-1 subunit; sodium pump subunit alpha-1; Na+, K+ ATPase alpha subunit; Na(+)/K(+) ATPase alpha
Cat.#:ATP1A1-460HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ATP1A1 Protein, His-tagged
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Cat.#:ATP1A1-461RTag:His
Source (Host):E. coliSpecies:Rabbit
Product nameRecombinant Rabbit ATP1A1 Protein, His-tagged
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Cat.#:ATP1A1-10004HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ATP1A1, His-tagged
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Cat.#:ATP1A1-102HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ATP1A1 protein
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Cat.#:ATP1A1-293HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human ATP1A1 protein, MYC/DDK-tagged
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Cat.#:ATP1A1-2113MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ATP1A1 Protein
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Cat.#:ATP1A1-852RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat ATP1A1 Protein
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Cat.#:ATP1A1-446RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey ATP1A1 Protein, His-tagged
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Cat.#:ATP1A1-7070CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ATP1A1
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Cat.#:ATP1A1-8613HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human ATP1A1 293 Cell Lysate
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Involved Pathway

ATP1A1 involved in several pathways and played different roles in them. We selected most pathways ATP1A1 participated on our site, such as cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP1A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
cGMP-PKG signaling pathway
KCNJ8; PPP3CC; PPP1R12A; AGTR1A; PIK3R2; PDE5A; ATP2A1; SLC25A5; PLCB2; NFATC2
cAMP signaling pathway
GRIN2A; AMH; RRAS; PDE4B; ATP1B4; CALM1; CREB3L1; GRIA2; HCAR2; MLLT4
Cardiac muscle contraction
ATP1B1B; TPM3; ATP1B2A; COX7C; CACNA1SB; TNNC1A; COX6A2; COX7A2; CACNA1C; CACNG2A
Adrenergic signaling in cardiomyocytes
ADCY1; AKT2L; PPP2R2BB; AKT2; GNAQ; CACNA1SA; PIK3R3; ATP2B3B; CACNG1A; CACNG2A
Insulin secretion
ATP1A1; GNAS; PLCB4; INS1; CAMK2B; RAB3A; CREB5; SLC2A1; GNA11; CAMK2A
Thyroid hormone synthesis
CANX; PRKCG; SLC26A4; TTF2; GPX8; LRP2; ATF4; TSHB; ATP1B3; PRKCA
Thyroid hormone signaling pathway
KAT2B; RCAN1; SRC; ATP1A2; FXYD2; PRKACA; PLCG2; STAT1; GSK3B; ATP1B3
Aldosterone-regulated sodium reabsorption
PIK3R3; ATP1A3; FXYD4; SFN; PIK3CB; PIK3R5; PRKCA; PDPK1; ATP1A1; HSD11B2
Endocrine and other factor-regulated calcium reabsorption
KLK1B26; ATP1B3; PRKACB; ESR1; SLC8A1; RAB11A; ATP1B2; DNM3; GNAQ; KLK1B9
Proximal tubule bicarbonate reclamation
ATP1A1; ATP1A2; AQP1; ATP1B4; SLC9A3; PCK1; ATP1A3; ATP1B2; GLS2; ATP1A4
Salivary secretion
BEST2; CST1; DMBT1; ATP1A1; VAMP2; Slc4a2; CALML5; PLCB3; MUC5B; AMY1B
Gastric acid secretion
CALM2; CAMK2G; GNAQ; KCNJ16; ATP1A3; MYLK; ATP1B1; PRKCG; GAST; ATP1A1
Pancreatic secretion
RAB27B; CTRB1; SLC26A3; ITPR3; Adcy4; CPA2; CA2; PLA2G12A; KCNQ1; RAB11A
Carbohydrate digestion and absorption
PIK3R5; PRKCB; HK2; PLCB2; PIK3R2; SLC2A5; AMY1B; PIK3CB; HKDC1; GNAT3
Protein digestion and absorption
SLC8A2; ATP1A4; PRSS2; SLC9A3; CELA2A; SLC8A1; COL6A6; COL18A1; CPA2; CELA3A
Bile secretion
SLC9A1; SLCO1B3; EPHX1; SLCO1A4; ABCG2; ATP1A4; SCARB1; Adcy4; SLC5A1; ABCB1A
Mineral absorption
Trf; ATP1A4; ATP1A1; SLC5A1; MT1H; SLC34A2; SLC8A1; SLC26A3; S100G; SLC40A1

Protein Function

ATP1A1 has several biochemical functions, for example, ADP binding, ATP binding, ankyrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP1A1 itself. We selected most functions ATP1A1 had, and list some proteins which have the same functions with ATP1A1. You can find most of the proteins on our site.
Function
Related Protein
Function ADP binding
Related Protein TAP1; ERN1; PRKAG2; APAF1; CYB5R3; MYH10; VCP; MYH9; PRPS2; P2RY1
Function ATP binding
Related Protein EPHB4B; LACE1; NAIP6; DYRK3; RAD51; GM711; PRKCQ; KIF6; ACTA2; ATP2B2
Function ankyrin binding
Related Protein SLC4A1; SLC8A1; SPTBN1; FLNC; PLEC; NRCAM; PTBP3; RHBG; CDH1; ATP1A1
Function chaperone binding
Related Protein HES1; BAG5; CXorf41; TSACC; GRPEL2; USP13; SDF2L1; INS1; CALR; ATP1A3
Function phosphatase activity
Related Protein CAR3; DUSP8A; ALP3; PTPRNA; MTMR1B; CA3; ALPI.2; DUSP27; PTPN2B; MINPP1A
Function phosphatidylinositol 3-kinase binding
Related Protein CALM3; HCST; JAK2; LCK; IGF1RA; PIK3R1; IGF1RB; IGF1R; IRS4; INSRA
Function potassium ion binding
Related Protein PKM2; PKM; KCNA4; PKLR; ATP1A1; SLC24A4A; SLC24A2; KCNJ11; HDAC4; PDXK
Function protein binding
Related Protein RPH3AL; RPIA; CNTROB; HBZ; NOV; FOXP4; NTRK1; NOS1; RNF165; SETMAR
Function protein domain specific binding
Related Protein CASP2; TBL1X; ARHGEF4; LIN7B; MPP5; HMGB2; VAPA; PHRF1; DYNLL1; IST1
Function protein kinase binding
Related Protein EEF1A1; BCAR1; STAP1; PTK2; SPAG16; Fert2; LIMS1; CCNL1; JAK2; TELO2
Function sodium ion binding
Related Protein ATP1A1; SLC24A5; SLC24A1; CAPN3; SLC34A2; SLC24A4; SLC24A2; PDXK; SLC24A4A; SCN9A
Function sodium:potassium-exchanging ATPase activity
Related Protein ATP1A1A.4; ATP1A3A; ATP1A1A.3; ATP1A3; ATP1A1A.1; ATP1B2; ATP1A1B; ATP1A1; ATP1A1A.2; FXYD2
Function contributes_to sodium:potassium-exchanging ATPase activity
Related Protein ATP1B1; ATP1B2; ATP1A1; ATP1A2; ATP1B3
Function steroid hormone binding
Related Protein ESR2A; ESR2B; ATP1A1; ATP1A2; GPR30; NR3C1; ATP1A3

Interacting Protein

ATP1A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP1A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP1A1.
TPT1; ERBB2; GTF2F2; TNFRSF1A; TNFRSF1B; Tpt1; TRADD; SMAD2; NDRG1; SNX6; SNAPIN; EZH2; 15-deoxy-delta(12,14