atp1a1
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  • Official Full Name
  • ATPase, Na+/K+ transporting, alpha 1 polypeptide
  • Background
  • This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
  • Synonyms
  • ATP1A1; ATPase, Na+/K+ transporting, alpha 1 polypeptide; sodium/potassium-transporting ATPase subunit alpha-1; sodium pump 1; Na+/K+ ATPase 1; Na,K-ATPase alpha-1 subunit; sodium pump subunit alpha-1; Na+, K+ ATPase alpha subunit; Na(+)/K(+) ATPase alpha
Cat.#:ATP1A1-460HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ATP1A1 Protein, His-tagged
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Cat.#:ATP1A1-461RTag:His
Source (Host):E. coliSpecies:Rabbit
Product nameRecombinant Rabbit ATP1A1 Protein, His-tagged
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Cat.#:ATP1A1-10004HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ATP1A1, His-tagged
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Cat.#:ATP1A1-102HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ATP1A1 protein
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Cat.#:ATP1A1-293HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human ATP1A1 protein, MYC/DDK-tagged
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Cat.#:ATP1A1-2113MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ATP1A1 Protein
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Cat.#:ATP1A1-852RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat ATP1A1 Protein
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Cat.#:ATP1A1-446RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey ATP1A1 Protein, His-tagged
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Cat.#:ATP1A1-7070CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ATP1A1
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Cat.#:ATP1A1-8613HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human ATP1A1 293 Cell Lysate
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Involved Pathway

ATP1A1 involved in several pathways and played different roles in them. We selected most pathways ATP1A1 participated on our site, such as cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP1A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
cGMP-PKG signaling pathway
FXYD2; MEF2D; GTF2I; NPPB; PDE3A; MYLK4; AGTR1A; SRF; MEF2A; IRS2
cAMP signaling pathway
HCAR2; HTR4; GNAS; NFKB1; PIK3CA; GPR81; GABBR1; AMH; PDE4C; GRIA4
Cardiac muscle contraction
TPMA; ATP1A2A; CACNB3; MYL2; COX8A; ATP1A1; CACNB2; ATP1B3B; COX6A2; COX7A3
Adrenergic signaling in cardiomyocytes
SCN1B; Adcy4; SCN1BA; MAPK14; SCN4BA; PPP1CB; PPP2R5EA; PPP2R5D; ATF4; GNA11A
Insulin secretion
KCNJ11; PRKCA; KCNMB3; ADCYAP1; SLC2A2; FXYD2; INS; PRKCG; ATP1B1; PLCB3
Thyroid hormone synthesis
CREB3L1; CREB5; ATP1B4; DUOX2; CREB3L3; PRKCG; HSP90B1; ATF4; ITPR1; ITPR3
Thyroid hormone signaling pathway
ATP1B4; TBC1D4; RXRA; RAF1; SLC16A10; PDPK1; THRB; ACTB; SLC2A1; SLC9A1
Aldosterone-regulated sodium reabsorption
SFN; IRS1; ATP1B3; PIK3R2; PRKCG; SGK1; PRKCB; ATP1A3; SCNN1G; PIK3CA
Endocrine and other factor-regulated calcium reabsorption
ESR1; PLCB1; ATP1A1; ATP1B3; PRKCA; PRKACA; KLK1B9; DNM3; GNAS; RAB11A
Proximal tubule bicarbonate reclamation
PCK2; GLUD1; FXYD2; AQP1; ATP1B4; Car4; ATP1A2; SLC4A4; GLUD2; GLS
Salivary secretion
ATP2B4; ATP1A4; CD38; PLCB1; PRH2; NOS1; PRKCG; CST3; Adcy4; PRKCB
Gastric acid secretion
SSTR2; CALML5; CALM1; PRKCB; PRKACB; GAST; KCNK10; PRKCG; ATP1B2; ATP1A3
Pancreatic secretion
PLA2G5; CPA2; PLA2G12A; CPB1; PLCB4; ATP2A3; PLCB1; CELA2A; PRKCA; LOC780933
Carbohydrate digestion and absorption
AKT2; PIK3CD; SLC37A4; ATP1A3; PIK3R1; G6PC; AKT1; ATP1A4; TAS1R3; ATP1A2
Protein digestion and absorption
CPA2; DPP4; CELA2A; ELN; CPB2; COL7A1; SLC8A1; KCNQ1; ATP1A1; CPA1
Bile secretion
SLC22A7; HMGCR; SCARB1; ATP1A2; ATP1B1; SLCO1A2; Adcy4; SULT2A1; PRKACB; SLC27A5
Mineral absorption
SLC26A9; ATP2B1; MT1M; MT1A; ATP1B3; ATP1B4; CLCN2; SLC5A1; ATP1A1; ATP1A2

Protein Function

ATP1A1 has several biochemical functions, for example, ADP binding, ATP binding, ankyrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP1A1 itself. We selected most functions ATP1A1 had, and list some proteins which have the same functions with ATP1A1. You can find most of the proteins on our site.
Function
Related Protein
Function ADP binding
Related Protein MYO7A; ADCK3; P2RY1; GLUD2; ABCG1; ATP1A1; ERN1; MYH10; PRKAG2; GCLC
Function ATP binding
Related Protein AKT3A; DAPK1; CPS1; DAPK2A; CLCN7; PPP1CA; CLCN4-2; P2RX4; DCLK1A; UBE2G2
Function ankyrin binding
Related Protein SPTBN1; ATP1A1; SLC4A1; RHCG; KCTD6; FLNC; KCNJ11; SCN5A; CDH1; KCNQ2
Function chaperone binding
Related Protein CDC37L1; CALR; DNAJA2; BAG5; BIRC5; DNAJB1; RNF207; PACRG; H2-KE2; BAG1
Function phosphatase activity
Related Protein CTDSPLA; DUSP13A; DUSP19B; ATP1A1; MINPP1B; DUSP8A; CTDNEP1; PTPN2B; MTMR7B; PTPRDB
Function phosphatidylinositol 3-kinase binding
Related Protein PDGFRB; INSRR; CORO1A; FLT3; INSR; DAB1; IRS2; JAK2; HCST; TYRO3
Function potassium ion binding
Related Protein HDAC4; SLC24A4; ATP1A1; KCNJ11; PKMB; SLC24A4A; SLC24A1; PKM2; PDXK; SLC24A5
Function protein binding
Related Protein CCDC43; COG2; TIMM10; PPP2R2B; SLC30A2; PTK7; H3F3A; NUP54; ATP6V1E2; SAV1
Function protein domain specific binding
Related Protein YWHAQA; HGS; HIST2H4; SERPINB1A; CRB3; HIST1H4D; UNC13A; YWHAE2; CSNK2B; ZNF521
Function protein kinase binding
Related Protein CCNT2B; GRIN2A; TICAM1; PTPN1; GPRC5B; TBL2; PARN; NPR1; ZFP36; TCF7L2
Function sodium ion binding
Related Protein SLC24A4A; CAPN3; SLC24A5; SCN9A; PDXK; SLC24A2; SLC24A4; ATP1A1; SLC34A2; SLC24A1
Function sodium:potassium-exchanging ATPase activity
Related Protein ATP1A1B; ATP1A2A; ATP4A; FXYD2; ATP1A2; ATP1B3; ATP1A3B; ATP1A1; ATP1A1A.5; ATP1A3
Function contributes_to sodium:potassium-exchanging ATPase activity
Related Protein ATP1A1; ATP1B3; ATP1B1; ATP1A2; ATP1B2
Function steroid hormone binding
Related Protein ATP1A2; NR3C1; ATP1A1; ESR2A; GPR30; ATP1A3; ESR2B

Interacting Protein

ATP1A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP1A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP1A1.
TPT1; ERBB2; GTF2F2; TNFRSF1A; TNFRSF1B; Tpt1; TRADD; SMAD2; NDRG1; SNX6; SNAPIN; EZH2; 15-deoxy-delta(12,14