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ATP6V1D

Official Full Name

ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
Overview

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c, c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes the V1 domain D subunit protein.
Synonyms

ATP6V1D; ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D; ATP6M, ATPase, H+ transporting, lysosomal (vacuolar proton pump); V-type proton ATPase subunit D; VATD; VMA8; V-ATPase D subunit; V-ATPase subunit D; vacuolar H-ATPase subunit D; vacuolar p;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Rhesus Macaque
Zebrafish

Source

E.coli
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	ATP6V1D-10045H	Recombinant Human ATP, His-tagged	E.coli	His	1-247a.a.	$319 / 25ug
Human	ATP6V1D-1005H	Recombinant Human ATP6V1D protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	ATP6V1D-50HCL	Recombinant Human ATP6V1D lysate	HEK293	N/A		Inquiry
Human	ATP6V1D-1284HF	Recombinant Full Length Human ATP6V1D Protein, GST-tagged	In Vitro Cell Free System	GST	247 amino acids	Inquiry
Mouse	ATP6V1D-2163M	Recombinant Mouse ATP6V1D Protein	Mammalian Cell	His		Inquiry
Mouse	ATP6V1D-879M	Recombinant Mouse ATP6V1D Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	ATP6V1D-879M-B	Recombinant Mouse ATP6V1D Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rhesus Macaque	ATP6V1D-468R	Recombinant Rhesus monkey ATP6V1D Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	ATP6V1D-297R	Recombinant Rhesus Macaque ATP6V1D Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rhesus Macaque	ATP6V1D-297R-B	Recombinant Rhesus Macaque ATP6V1D Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	ATP6V1D-7632Z	Recombinant Zebrafish ATP6V1D	Mammalian Cell	His		Inquiry
Chicken	ATP6V1D-4840C	Recombinant Chicken ATP6V1D	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

ATP6V1D involved in several pathways and played different roles in them. We selected most pathways ATP6V1D participated on our site, such as Oxidative phosphorylation, Metabolic pathways, Phagosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP6V1D were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Oxidative phosphorylation	NDUFA8;NDUFS7;UQCRC2;COX5B2;ATP6V0E2;ATP6V1A;NDUFS8A;ATP6V0B;UQCRB
Metabolic pathways	NDUFS6;AK9;PANK4;SDHC;IDH3B;ACSL3A;ADH2-2;SPTLC2;MTHFR
Phagosome	SEC22BB;ACTG1;FCAR;RAC1;CD209B;TUBA1A;CTSSA;ATP6V1AA;ATP6AP1
Synaptic vesicle cycle	CPLX2;UNC13C;ATP6V0C;ATP6V1G2;RIMS1;ATP6V1G1;SNAP25;ATP6V0D2;SLC17A8
Collecting duct acid secretion	ATP6V1E2;ATP6V0D1;ATP6V1C2;ATP6V0D2;Car2;ATP6V1G3;ATP6V0A1;TCIRG1;CLCNKB
Vibrio cholerae infection	ATP6V0E1;PLCG1;PLCG2;ATP6V0B;ATP6AP1;GNAS;ATP6V1H;PRKACB;ATP6V0C
Epithelial cell signaling in Helicobacter pylori infection	IKBKB;ATP6V1D;TCIRG1;ATP6V1C2;MAPK13;ATP6V1G2;F11R;ATP6V1G1;MAPK8
Rheumatoid arthritis	ATP6V1D;ATP6V1B1;ATP6V0A2;CD86;HLA-DRB4;LTB;ATP6V1F;ANGPT1;HLA-DPB1

ATP6V1D has several biochemical functions, for example, ATPase activity, coupled to transmembrane movement of substances, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP6V1D itself. We selected most functions ATP6V1D had, and list some proteins which have the same functions with ATP6V1D. You can find most of the proteins on our site.

Function	Related Protein
ATPase activity, coupled to transmembrane movement of substances	ABCB1;ABCB10;ABCD1;ABCA4;ABCC12;ABCB4;ABCC9;ABCB3L1;ABCA1
protein binding	ATP6V1C1;MYO10;CD276;PRPSAP1;AVPR1A;HEY2;CTAG2;LMO2;NLK

ATP6V1D has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP6V1D here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP6V1D.

VPS52; NR2F6; SMAD2; RRAGB; pi3p; MYC; MYH7; ATP6V1A; PSMC1; PPP2CA; CLTC; USP7; Tmed10; GOLT1B