atm
Share
  • Official Full Name
  • ataxia telangiectasia mutated
  • Background
  • The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle;checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins,;including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA;repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell;cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability.Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder.
  • Synonyms
  • ATM; ataxia telangiectasia mutated; ATA, ataxia telangiectasia mutated (includes complementation groups A, C and D) , ATC, ATD, ATDC; serine-protein kinase ATM; TEL1; telomere maintenance 1; homolog (S. cerevisiae); TELO1; AT mutated; A-T mutated; TEL1,
Cat.#:ATM-185HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human ATM protein, GST-tagged
+Inquiry
Cat.#:ATM-6852HTag:His|GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ATM protein, His & GST-tagged
+Inquiry
Cat.#:ATM-848HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human ATM
+Inquiry
Cat.#:ATM-953HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ATM protein, GST-tagged
+Inquiry
Cat.#:ATM-9987HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ATM, GST-tagged
+Inquiry
Cat.#:ATM-2094MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ATM Protein
+Inquiry
Cat.#:Atm-6853MTag:His|T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Atm protein, His & T7-tagged
+Inquiry
Cat.#:ATM-3968CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ATM
+Inquiry

Involved Pathway

ATM involved in several pathways and played different roles in them. We selected most pathways ATM participated on our site, such as NF-kappa B signaling pathway, FoxO signaling pathway, Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATM were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
NF-kappa B signaling pathway
NFKBIA; TNF; IL-8; CCL13; Ccl21a; RIPK1; TRADD; Ccl21c; BIRC2; BIRC3
FoxO signaling pathway
SGK1; TGFB1; PLK2B; ATM; TGFB2; MAPK9; NLK1; NLK2; PLK3; GADD45AB
Cell cycle
CENPH; MLF1IP; MAU2; CCNE2; CUL1; KIF2A; BARD1; MASTL; CDKN2D; CLASP1A
p signaling pathway
PTEN; SIAH1A; PTENA; Casp3; IGFBP3; CCNG2; TRP53; BIDA; TP53AIP1; SHISA5
Apoptosis
IRF2A; CFLARA; PLECA; IRF6; IRF4A; BCL2L1; CAPN1; PRKACAB; PRKAR2AB; RNF8
HTLV-I infection
TBP; SFPI1; XPO1; ANAPC2; POLE; POLB; PIK3CG; GPS2; NFATC2; AKT1
Transcriptional misregulation in cancer
TRP53; ETV7; PAX3; IL-8; HIST1H3G; RXRB; NGFR; DOT1L; SSX2; ITGAM
MicroRNAs in cancer
CCNE1; CCNE2; VIM; KIF23; MET; SHC4; HMOX1; TPM1; MCL1; ABCB1A

Protein Function

ATM has several biochemical functions, for example, 1-phosphatidylinositol-3-kinase activity, ATP binding, DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ATM itself. We selected most functions ATM had, and list some proteins which have the same functions with ATM. You can find most of the proteins on our site.
Function
Related Protein
Function 1-phosphatidylinositol-3-kinase activity
Related Protein PIK3CA; PIK3CB; PIK3R3; PIK3C2A; PIK3C2G; PIK3CG; PIK3C2B; ATM; PIK3C3; PIK3CD
Function ATP binding
Related Protein IRAK1; DDX39; MYO1C; TNNI3K; GATC; JAK2A; HSPA1B; ATAD5B; DHX32; NAIP7
Function DNA binding
Related Protein MYC; RARAB; HNRPK; ZNF683; ZFAND3; ZNF238; NR2F1B; HIST1H2B5; APEX2; ZNF8
Function DNA-dependent protein kinase activity
Related Protein HMGA2; XRCC6BP1; ALPK2; PRKDC; ATM
Function histone serine kinase activity
Related Protein AURKB; PRKAA1; AURKA; AURKC; ATM; PRKAA2
Function protein N-terminus binding
Related Protein PEX5; MECP2; RPS21; SNCA; ACTN4; TSC1; BIRC2; KCNIP1; RND2; PHB2
Function protein binding
Related Protein IFT57; MARCH2; FBXO4; TMEM31; FAM72A; C21orf7; FOXJ2; CDK7; ZNF133; STRADB
Function protein complex binding
Related Protein LEPRE1; DRD1; COG2; TULP3; Ctsl; RRAS; KRIT1; CDK5RAP2; TG; FBN1
Function protein dimerization activity
Related Protein TFE3B; HER1; AHR1A; HIF1AL; SREBF1; SRFA; POLR2J; MITFA; HER5; HPS4
Function protein serine/threonine kinase activity
Related Protein SMOK3A; LRRK2; PRKCBA; DAPK2; CDC7; PRKD1; MAP4K4; STK16; CAMK1DA; NEK3

Interacting Protein

ATM has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATM here. Most of them are supplied by our site. Hope this information will be useful for your research of ATM.
TELO2; TERF1; TTI1; NABP2; ATMIN

ATM Related Articles

Zhang, YQ; Jiang, CL; et al. Elevated Aurora B expression contributes to chemoresistance and poor prognosis in breast cancer. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY 8:751-757(2015).
Liu, H; Yang, WF; et al. Nimotuzumab abrogates acquired radioresistance of KYSE-150R esophageal cancer cells by inhibiting EGFR signaling and cellular DNA repair. ONCOTARGETS AND THERAPY 8:509-518(2015).