Active Recombinant Human ATM Protein (Full Length), Flag-tagged

• Cat.No.: ATM-186H
• Product Overview: Recombinant active human FLAG-tagged ATM full length protein was expressed in a mammalian cell line.

Specification

• Description: The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder.
• Source: Mammalian cell line
• Species: Human
• Tag: Flag
• Form: Protein in frozen storage buffer.
• Molecular Mass: 352 kDa
• Storage: 6 months at -70 centigrade.

Gene Information

• Gene Name: ATM ATM serine/threonine kinase [ Homo sapiens (human) ]
• Official Symbol: ATM
• Synonyms: ATM; ATM serine/threonine kinase; AT1; ATA; ATC; ATD; ATE; ATDC; TEL1; TELO1; serine-protein kinase ATM; A-T mutated; AT mutated; TEL1, telomere maintenance 1, homolog; ataxia telangiectasia mutated; serine/threonine kinase ATM; EC 2.7.11.1
• Gene ID: 472
• mRNA Refseq: NM_000051
• Protein Refseq: NP_000042
• MIM: 607585
• UniProt ID: Q13315