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ENPP2

  • Official Full Name

    ectonucleotide pyrophosphatase/phosphodiesterase 2

  • Overview

    The protein encoded by this gene functions as both a phosphodiesterase, which cleaves phosphodiester bonds at the 5 end of oligonucleotides, and a phospholipase, which catalyzes production of lysophosphatidic acid (LPA) in extracellular fluids. LPA evokes growth factor-like responses including stimulation of cell proliferation and chemotaxis. This gene product stimulates the motility of tumor cells and has angiogenic properties, and its expression is upregulated in several kinds of carcinomas. The gene product is secreted and further processed to make the biologically active form. Several alternatively spliced transcript variants encoding different isoforms have been identified.
  • Synonyms

    ENPP2; ectonucleotide pyrophosphatase/phosphodiesterase 2; PDNP2; ectonucleotide pyrophosphatase/phosphodiesterase family member 2; ATX; autotaxin; PD IALPHA; ATX X; ATX-X; Autotaxin t; E NPP 2; E-NPP 2; ENPP2_HUMAN; Extracellular lysophospholipase D; FLJ26803; LysoPLD; NPP2; PD-IALPHA; Phosphodiesterase I alpha; Phosphodiesterase I/nucleotide pyrophosphatase 2; Plasma lysophospholipase D; autotaxin-t; OTTHUMP00000228158; OTTHUMP00000228159; OTTHUMP00000228161; OTTHUMP00000228162; phosphodiesterase I/nucleotide py;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • Human Cell
  • Insect cell
  • Insect Cells
  • Mammalian Cell
  • Mammalian cells
  • Sf9 Insect Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ENPP2-3123H Active Recombinant Human ENPP2, His-tagged HEK293 His
Human ENPP2-6998H Recombinant Human ENPP2, GST-tagged Sf9 Insect Cell GST 36 aa-end
Human ENPP2-570H Recombinant Human ENPP2 protein(Asp49-Ile863), His-tagged HEK293 N-His Asp49-Ile863
Human ENPP2-566H Recombinant Human ENPP2, His-tagged Sf9 Insect Cell His
Human ENPP2-1556HCL Recombinant Human ENPP2 cell lysate Human Cell N/A
Human ENPP2-076H Recombinant Human ENPP2 Protein, His-tagged Insect cell His 36-863
Human ENPP2-567H Active Recombinant Human ENPP2 Protein, His-tagged Mammalian cells His
Human ENPP2-63H Recombinant Human ENPP2 protein, His-tagged HEK293 His Asp49-Ile863
Human ENPP2-013H Recombinant Human ENPP2 Protein, His-tagged Insect Cells His
Human ENPP2-794H Recombinant Human ENPP2 Protein HEK293 863
Human ENPP2-2857H Recombinant Human ENPP2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human ENPP2-3410H Recombinant Human ENPP2 protein, His-tagged E.coli His 30-383 aa
Human ENPP2-03H Active Recombinant Human ENPP2 protein, His-tagged HEK293 His Asp49-Ile863
Human ENPP2-795H Recombinant Human ENPP2 Protein HEK293 794
Human ENPP2-2857H-B Recombinant Human ENPP2 Protein Pre-coupled Magnetic Beads HEK293
Human ENPP2-2667H Recombinant Human ENPP2 Protein (Ser637-Ile863), N-His tagged E.coli N-His Ser637-Ile863
Human ENPP2-2668H Recombinant Human ENPP2 Protein (Ser637-Ile905), His tagged E.coli His Ser637-Ile905
Human ENPP2-552H Recombinant Human ENPP2 Protein, His-tagged E.coli His Arg637~Lys905
Mouse Enpp2-1189M Recombinant Mouse Enpp2, His tagged Human Cell His
Mouse ENPP2-1939MCL Recombinant Mouse ENPP2 cell lysate Human Cell N/A
Mouse Enpp2-1190M Active Recombinant Mouse Enpp2 Protein, His-tagged Mammalian cells His
Mouse Enpp2-2797M Recombinant Mouse Enpp2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Enpp2-2797M-B Recombinant Mouse Enpp2 Protein Pre-coupled Magnetic Beads HEK293
Rat ENPP2-2104R Recombinant Rat ENPP2 Protein Mammalian Cell His
Rat ENPP2-1761R-B Recombinant Rat ENPP2 Protein Pre-coupled Magnetic Beads HEK293
Rat Enpp2-553R Recombinant Rat Enpp2 Protein, His-tagged E.coli His Thr54~Trp254
Rat ENPP2-1761R Recombinant Rat ENPP2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey ENPP2-1209C Active Recombinant Cynomolgus ENPP2 Protein, His-tagged HEK293 His
Zebrafish ENPP2-10881Z Recombinant Zebrafish ENPP2 Mammalian Cell His
Chicken ENPP2-4205C Recombinant Chicken ENPP2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ENPP2 Related Research Area

ENPP2 involved in several pathways and played different roles in them. We selected most pathways ENPP2 participated on our site, such as Ether lipid metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ENPP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Ether lipid metabolismPAFAH1B1B;PLA2G4D;PLA2G3;PPAP2A;PLA2G2F;PLA2G4AA;PPAP2CB;EPT1;TMEM86B

ENPP2 has several biochemical functions, for example, alkylglycerophosphoethanolamine phosphodiesterase activity, calcium ion binding, hydrolase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ENPP2 itself. We selected most functions ENPP2 had, and list some proteins which have the same functions with ENPP2. You can find most of the proteins on our site.

Function Related Protein
alkylglycerophosphoethanolamine phosphodiesterase activity
calcium ion bindingACTN3B;PROCA;PCDH2G7;FAT4;PPP3R2;KCNIP3A;CABP7;CPS1;APCS
hydrolase activityELA3L;ATP1A1A.2;USP43;DDX39AA;ATAD1B;USP12A;GPN3;TMPPE;PRSS52
lysophospholipase activityPLA2G15;PLA2G4F;PLB1;ASPG;Cel;LYPLA1;ENPP2;PLA2G4AA;PLA2G4A
nucleic acid bindingZBTB8B;ZSCAN4D;HELQ;CPSF1;DRL;GLI2B;TARDBPL;ZNF843;SP3A
nucleotide diphosphatase activityENPP2;ENPP1
phosphodiesterase I activityENPP2;APEX1;ENPP1;FAN1
polysaccharide bindingCLEC4G;ENDOU;ENPP2;GM106;VTNA;VTNB;TINAG;ENPP1;AGL
scavenger receptor activityCD5L;LOXL3;TMPRSS4;TMPRSS5;SCARA5;PGBD1;LGALS3BPA;CD6;ENDOU
transcription factor bindingBCL10;PDX1;EGR1;ARNT;NAB1;NR0B2A;HEYL;DNAJA3;E2F1
zinc ion bindingTRIM50;P2RX1;LHX5;GTF2H2C_2;ZDHHC18;ADH1B;GATAD1;TAF3;MT2A

ENPP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ENPP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ENPP2.

Dlg4; HSPB1

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