Brain natriuretic peptide (BNP), now known as B-type natriuretic peptide (also BNP) or GC-B, is a 32 amino acid polypeptide secreted by the ventricles of the heart in response to excessive stretching of heart muscle cells (cardiomyocytes). BNP is named as such because it was originally identified in extracts of porcine brain, although in humans it is produced mainly in the cardiac ventricles. BNP is co-secreted along with a 76 amino acid N-terminal fragment (NT-pro BNP) which is biologically inactive. BNP binds to and activates the atrial natriuretic factor receptors NPRA, and to a lesser extent NPRB, in a fashion similar to atrial natriuretic peptide (ANP) but with 10-fold lower affinity. The biological half-life of BNP, however, is twice as long as that of ANP, and that of NT-proBNP is even longer, making these peptides better targets than ANP for diagnostic blood testing.
BNP involved in several pathways and played different roles in them. We selected most pathways BNP participated on our site, such as cGMP-PKG signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with BNP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
BNP has several biochemical functions, for example, hormone activity. Some of the functions are cooperated with other proteins, some of the functions could acted by BNP itself. We selected most functions BNP had, and list some proteins which have the same functions with BNP. You can find most of the proteins on our site.
Function hormone activity
Related Protein UTS2A; INSB; LEP; INHBE; CCK; IGF2A; UCN2; PRL3C1; INSL5A; IAPP
BNP Related Articles
Derosa, G; Romano, D; et al. The effects of canrenone on inflammatory markers in patients with metabolic syndrome. ANNALS OF MEDICINE 47:47-52(2015).
Wang, Y; Wu, JJ; et al. Magnetic microparticle-based SELEX process for the identification of highly specific aptamers of heart marker--brain natriuretic peptide. MICROCHIMICA ACTA 182:331-339(2015).