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BRCA2

Official Full Name

breast cancer 2, early onset
Overview

BRCA2 (Breast Cancer 2 susceptibility protein) is a protein that in humans is encoded by the BRCA2 gene. BRCA2 orthologs have been identified in most mammals for which complete genome data are available. BRCA2 belongs to the tumor suppressor gene family and the protein encoded by this gene is involved in the repair of chromosomal damage with an important role in the error-free repair of DNA double strand breaks.
Synonyms

BRCA2; breast cancer 2, early onset; FACD, FANCD, FANCD1, Fanconi anemia, complementation group D1; breast cancer type 2 susceptibility protein; BRCA1/BRCA2 containing complex; subunit 2; BRCC2; FAD; FAD1; fanconi anemia group D1 protein; breast cancer 2;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Rat
Zebrafish

Source

E.coli
HEK293
Insect Cell
Mammalian Cell
Wheat Germ

Tag

His
His (Fc)
Avi
His|GST
His|T7
N/A
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	BRCA2-27673TH	Recombinant Human BRCA2	Wheat Germ	N/A	100 amino acids	Inquiry
Human	BRCA2-6856H	Recombinant Human BRCA2 protein, His & T7-tagged	E.coli	His/T7	Lys2308~His2537 (Accession # P51587)	Inquiry
Human	BRCA2-232H	Recombinant Human BRCA2, His & GST-tagged	Insect Cell	His/GST	Met1-Val314	Inquiry
Human	BRCA2-0792H	Recombinant Human BRCA2 Protein (Lys2308-His2537), N-His tagged	E.coli	N-His	Lys2308-His2537	Inquiry
Mouse	Brca2-6857M	Recombinant Mouse Brca2 protein, His & T7-tagged	E.coli	His/T7	Glu2990~Ala3232 (Accession # P97929)	Inquiry
Mouse	BRCA2-2480M	Recombinant Mouse BRCA2 Protein	Mammalian Cell	His		Inquiry
Mouse	BRCA2-1084M-B	Recombinant Mouse BRCA2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	BRCA2-1084M	Recombinant Mouse BRCA2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	Brca2-6858R	Recombinant Rat Brca2 protein, His & T7-tagged	E.coli	His/T7	Ala2913~Pro3151 (Accession # O35923)	Inquiry
Zebrafish	BRCA2-6156Z	Recombinant Zebrafish BRCA2	Mammalian Cell	His		Inquiry
Chicken	BRCA2-5849C	Recombinant Chicken BRCA2	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
BRCA2 Related Articles

BRCA2 involved in several pathways and played different roles in them. We selected most pathways BRCA2 participated on our site, such as Homologous recombination, Fanconi anemia pathway, Pathways in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with BRCA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Homologous recombination	POLD4;POLD1;POLD2;BRCA2;NBN;RAD51L3;RAD51;XRCC3;RAD51D
Fanconi anemia pathway	DCLRE1A;BLM;BRCA1;POLN;MLH1;ERCC4;RMI1;REV1;REV3L
Pathways in cancer	RUNX1T1;HHIP;PIAS2;WNT5B;STAT5B;Fzd4;LAMA5;RAC1;GNG12
Pancreatic cancer	TGFA;RELA;BRCA2;AKT1;RAD51;BRAF;RALB;TGFBR2;SMAD2

BRCA2 has several biochemical functions, for example, H3 histone acetyltransferase activity, H4 histone acetyltransferase activity, gamma-tubulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BRCA2 itself. We selected most functions BRCA2 had, and list some proteins which have the same functions with BRCA2. You can find most of the proteins on our site.

Function	Related Protein
H3 histone acetyltransferase activity	KAT2A;ELP3;BRCA2
H4 histone acetyltransferase activity	ELP3;NAA50;HAT1;NAA60;NAT15;BRCA2
gamma-tubulin binding	BLOC1S2;RAD51L3;NDRG1;LYN;RAD51D;RAB11FIP5;SPATC1;TUBGCP3;NME2
NOT histone acetyltransferase activity	BRCA2;BAZ1A;EDF1;ARRB1
protease binding	ITGA3;SERPINA1D;INS2;PANX1;CCDC71L;NFRKB;PINK1;SERPINC1;SRI
protein binding	WIBG;FRMPD4;FBXO46;FAM125B;CTLA2B;SCARF1;NCAPH2;DOT1L;TNNI2
single-stranded DNA binding	POLR2G;LUZP4;SSBP3B;NABP2;HNRNPK;ERCC4;SSBP4;PURB;MCM7

BRCA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BRCA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of BRCA2.

RAD51

Le Cigne, A; Menil-Philippot, V; et al. Transient expression of RAD51 in the late G2-phase is required for cell cycle progression in synchronous Physarum cells. GENES TO CELLS 19:755-765(2014).

Ren, X; Yan, T; et al. Nanosheet Au/Co3O4-based ultrasensitive nonenzymatic immunosensor for melanoma adhesion molecule antigen. BIOSENSORS & BIOELECTRONICS 58:345-350(2014).