C12orf5

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C12orf5

Official Full Name chromosome 12 open reading frame 5
Background This gene is regulated as part of the p53 tumor suppressor pathway and encodes a protein with sequence similarity to the bisphosphate domain of the glycolytic enzyme that degrades fructose-2,6-bisphosphate. The protein functions by blocking glycolysis and directing the pathway into the pentose phosphate shunt. Expression of this protein also protects cells from DNA damaging reactive oxygen species and provides some protection from DNA damage-induced apoptosis. The 12p13.32 region that includes this gene is paralogous to the 11q13.3 region. [provided by RefSeq, Jul 2008]
Synonyms C12ORF5; chromosome 12 open reading frame 5; FR2BP; TIGAR; fructose-2,6-bisphosphatase TIGAR; transactivated by NS3TP2 protein; fructose-2,6-bisphosphate 2-phosphatase; probable fructose-2,6-bisphosphatase TIGAR; TP53-induced glycolysis and apoptosis regulator;
    • Species :
    • Human
    • Source :
    • E.coli
    • HEK293
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    • TAT
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human C12ORF5-30300TH Recombinant Human C12ORF5, His-tagged E.coli His
    Human C12ORF5-30301TH Recombinant Human C12ORF5 E.coli N/A
    Human C12orf5-3371H Recombinant Human Chromosome 12 Open Reading Frame 5, His-tagged E.coli His
    Human C12orf5-508H Recombinant Human C12orf5 Protein, TAT-tagged E.coli TAT
    Human C12orf5-509H Recombinant Human C12orf5 Protein, GST-tagged Wheat Germ GST
    Human C12orf5-8316HCL Recombinant Human C12orf5 293 Cell Lysate HEK293 N/A

    C12orf5 involved in several pathways and played different roles in them. We selected most pathways C12orf5 participated on our site, such as Fructose and mannose metabolism, Central carbon metabolism in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with C12orf5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Fructose and mannose metabolism TPI1A; FBP1; AKR1B1L; TSTA3; DHRS13L1; PFKFB4L; GMPPA; FBP1B; ALDOCA; PFKFB2
    Central carbon metabolism in cancer RAF1; SLC7A5; HKDC1; PGAM2; HRAS; PIK3CD; MAPK3; PDHB; HIF1A; SIRT3

    C12orf5 has several biochemical functions, for example, bisphosphoglycerate 2-phosphatase activity, fructose-2,6-bisphosphate 2-phosphatase activity, phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by C12orf5 itself. We selected most functions C12orf5 had, and list some proteins which have the same functions with C12orf5. You can find most of the proteins on our site.

    Function Related Protein
    bisphosphoglycerate 2-phosphatase activity PGAM2; BPGM; PGAM1; TIGARA; C12orf5; TIGARB
    fructose-2,6-bisphosphate 2-phosphatase activity PFKFB1; TIGARA; PFKFB2; C12orf5; PFKFB3; TIGARB; PFKFB4
    phosphatase activity SSH2B; CTDNEP1A; CAR3; MTMR1B; PTPRK; TIGARB; PHOSPHO2; PHOSPHO1; CDC14A; DUSP8A
    protein binding CLPTM1; POLR3F; SGPL1; BABAM1; EIF4G2; RBM44; CHAF1A; SMC2; TCEAL5; COMMD2

    C12orf5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with C12orf5 here. Most of them are supplied by our site. Hope this information will be useful for your research of C12orf5.

    RPL11

    Kobayashi, Y; Suzuki, K; et al. C9orf10 protein, a novel protein component of Pur alpha-containing mRNA-protein particles (Pur alpha-mRNPs): Characterization of developmental and regional expressions in the mouse brain. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY 56:723-731(2008).
    Resendes, BL; Kuo, SF; et al. Isolation from cochlea of a novel human intronless gene with predominant fetal expression. JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY 5:185-202(2004).

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