c12orf5
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  • Official Full Name
  • chromosome 12 open reading frame 5
  • Background
  • This gene is regulated as part of the p53 tumor suppressor pathway and encodes a protein with sequence similarity to the bisphosphate domain of the glycolytic enzyme that degrades fructose-2,6-bisphosphate. The protein functions by blocking glycolysis and directing the pathway into the pentose phosphate shunt. Expression of this protein also protects cells from DNA damaging reactive oxygen species and provides some protection from DNA damage-induced apoptosis. The 12p13.32 region that includes this gene is paralogous to the 11q13.3 region. [provided by RefSeq, Jul 2008]
  • Synonyms
  • C12ORF5; chromosome 12 open reading frame 5; FR2BP; TIGAR; fructose-2,6-bisphosphatase TIGAR; transactivated by NS3TP2 protein; fructose-2,6-bisphosphate 2-phosphatase; probable fructose-2,6-bisphosphatase TIGAR; TP53-induced glycolysis and apoptosis regulator;
Cat.#:C12orf5-508HTag:TAT
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human C12orf5 Protein, TAT-tagged
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Cat.#:C12orf5-509HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human C12orf5 Protein, GST-tagged
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Cat.#:C12orf5-3371HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Chromosome 12 Open Reading Frame 5, His-tagged
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Cat.#:C12ORF5-30300THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human C12ORF5, His-tagged
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Cat.#:C12ORF5-30301THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human C12ORF5
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Cat.#:C12orf5-8316HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human C12orf5 293 Cell Lysate
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Involved Pathway

C12orf5 involved in several pathways and played different roles in them. We selected most pathways C12orf5 participated on our site, such as Fructose and mannose metabolism, Central carbon metabolism in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with C12orf5 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Fructose and mannose metabolism
PFKP; AKR1B1; PFKFB2A; PFKFB1; ALDOB; TPI1A; AKR1B1L; PFKL; PMM1; HKDC1
Central carbon metabolism in cancer
TRP53; SCO2; SLC2A1; IDH1; FGFR1; RET; PTEN; GLS; PKM2; SLC2A2

Protein Function

C12orf5 has several biochemical functions, for example, bisphosphoglycerate 2-phosphatase activity, fructose-2,6-bisphosphate 2-phosphatase activity, phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by C12orf5 itself. We selected most functions C12orf5 had, and list some proteins which have the same functions with C12orf5. You can find most of the proteins on our site.
Function
Related Protein
Function bisphosphoglycerate 2-phosphatase activity
Related Protein C12orf5; PGAM1; TIGARA; TIGARB; PGAM2; BPGM
Function fructose-2,6-bisphosphate 2-phosphatase activity
Related Protein PFKFB1; C12orf5; PFKFB3; TIGARB; TIGARA; PFKFB4; PFKFB2
Function phosphatase activity
Related Protein PTPN20; PTPRJA; PPP1CC; PTPN2A; MTMR1B; DUSP8A; DUSP11; DUSP19B; PTPN4B; C12orf5
Function protein binding
Related Protein PKHD1L1; GNA14; HDC; RMND1; HOMER2; EYA2; WAC; ZFPM2; AUP1; CDK13

Interacting Protein

C12orf5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with C12orf5 here. Most of them are supplied by our site. Hope this information will be useful for your research of C12orf5.
RPL11

C12orf5 Related Articles

Kobayashi, Y; Suzuki, K; et al. C9orf10 protein, a novel protein component of Pur alpha-containing mRNA-protein particles (Pur alpha-mRNPs): Characterization of developmental and regional expressions in the mouse brain. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY 56:723-731(2008).
Resendes, BL; Kuo, SF; et al. Isolation from cochlea of a novel human intronless gene with predominant fetal expression. JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY 5:185-202(2004).