C3

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C3

Official Full Name complement component 3
Background C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.
Synonyms complement C3; Acylation Stimulating Protein Cleavage Product; ASP; C3 and PZP like alpha 2 macroglobulin domain containing protein 1; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1; C3; CO3_HUMAN; Complement C3 precursor; Complement C3c alpha'' chain fragment 2; Complement Component 3; Complement factor 3; CPAMD 1; CPAMD1
    • Species :
    • C. botulinum
    • Chicken
    • Clostridium botulinum D bacteriophage
    • Human
    • Mouse
    • Pig
    • Rabbit
    • Rat
    • Swine
    • Source :
    • C. botulinum
    • Clostridium botulinum D bacteriophage
    • E.coli
    • HEK293
    • HEK293T
    • Human Plasma
    • Human Serum
    • Mammalian Cell
    • Plasma
    • Yeast
    • Tag :
    • His
    • GST
    • T7
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human C3-01H Recombinant Human C3 Protein E.coli N/A
    Mouse C3-7632M Recombinant Mouse C3 protein, His-tagged E.coli His
    Human C3-10H Recombinant Human C3 protein, His-tagged HEK293 His
    Human C3-3052H Recombinant Human C3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse C3-732M Recombinant Mouse C3 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human C3-10522H Recombinant Human C3, His-tagged E.coli His
    Human C3-1149H Recombinant Human C3 Protein, His-tagged E.coli His
    Human C3-1841H Recombinant Human C3 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human C3-194H Native Human Complement C3c Human Plasma N/A
    Human C3-365H Native Human C3 Protein Human Serum N/A
    Human C3-558H Recombinant Human C3 Protein, His/GST-tagged E.coli His/GST
    Human C3-603H Recombinant Human C3 E.coli N/A
    Human C3-7631H Recombinant Human C3 protein, His-tagged E.coli His
    Human C3-7842H Recombinant Human C3 protein, His-tagged E.coli His
    Human C3-7H Human C3 Reference Standard N/A
    Human C3-8092H Native Human Plasma COMPLEMENT C (C3) Human Plasma N/A
    Human C3-8391H Native Human C3 Plasma N/A
    Mouse C3-33M Mouse C3 Reference Standard N/A
    Mouse C3-559M Recombinant Mouse C3 Protein, His/GST-tagged E.coli His/GST
    Mouse C3-7843M Recombinant Mouse C3 protein, His-tagged E.coli His
    Rat C3-1050R Recombinant Rat C3 Protein Mammalian Cell His
    Rat C3-561R Recombinant Rat C3 Protein, His/GST-tagged E.coli His/GST
    Rat C3-73R Rat C3 Reference Standard N/A
    Rat C3-7845R Recombinant Rat C3 protein, His-tagged E.coli His
    Rabbit C3-4324R Recombinant Rabbit C3 Protein Yeast N/A
    Chicken C3-6956C Recombinant Chicken C3 Mammalian Cell His
    C. botulinum C3-001C Native C. botulinum C3 Enzyme C. botulinum N/A
    Clostridium botulinum D bacteriophage C3-147C Native Botulinum C3 Enzyme Clostridium botulinum D bacteriophage N/A
    Swine C3-4325S Recombinant Swine C3 Protein Yeast N/A
    Pig C3-560P Recombinant Pig C3 Protein, His/GST-tagged E.coli His/GST
    Pig C3-7844P Recombinant Pig C3 protein, His & T7-tagged E.coli His/T7

    C3 involved in several pathways and played different roles in them. We selected most pathways C3 participated on our site, such as Phagosome, Complement and coagulation cascades, Pertussis, which may be useful for your reference. Also, other proteins which involved in the same pathway with C3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Phagosome MBL1; CTSSB.1; TUBA2; CTSL1B; BMA1; FCGR2C; NCF4; TLR2-1; THBS4B; ACTB
    Complement and coagulation cascades MBL2; LOC100514666; C1S; CR1; C9; SERPINA5; F11; CR2; C1QB; CR1L
    Pertussis GNAI2; LY96; C1R; C4BPA; C4A; Il23a; Il12b; TLR4; IL12B; MAPK12; CALM3
    Legionellosis SAR1B; CXCL3; Casp3; APAF1; HSPA1B; HSPA6; NFKBIA; Itgam&Itgb2; EEF1A2; NFKB2
    Leishmaniasis FCGR1; NOS2; TLR2; NFKBIA; ITGB2L; MARCKSL1; Itgam&Itgb2; HLA-DQB1; IRAK4; PTGS2
    Chagas disease (American trypanosomiasis) IL6; PPP2CA; CXCL8; GNA11; PPP2CB; MAPK8; PLCB3; TGFBR2; TGFBR1; ACE
    Staphylococcus aureus infection C1QB; HLA-DQB1; FPR1; FCGR3B; FCGR3; HLA-DRB5; H2-AB1; FCAR; PTAFR; HLA-DPA1
    Tuberculosis HLA-DMA; IFNA7; RFXANK; AKT1; PMAP-36; IFNA8; IFNA16; IFNG; HLA-DRB5; STAT1
    Herpes simplex infection Ifna11; SKP1; CLOCKA; HLA-DPB1; CFP; TRP53; TTC6; CD74; EEF1D; IFNA8
    Viral carcinogenesis PSMC1; MDM2; SNW1; GTF2H2C_2; REL; CCNE2; HIST2H4A; CCNA1; HIST1H2BE; GTF2H3
    Systemic lupus erythematosus C4A; HIST1H4I; HLA-DQA1; H2AFX; ACTN3; H2AFB1; HIST1H2AL; HIST1H2AF; HLA-DMB; HIST1H2AN

    C3 has several biochemical functions, for example, C5L2 anaphylatoxin chemotactic receptor binding, cofactor binding, endopeptidase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by C3 itself. We selected most functions C3 had, and list some proteins which have the same functions with C3. You can find most of the proteins on our site.

    Function Related Protein
    C5L2 anaphylatoxin chemotactic receptor binding C3
    cofactor binding PHYH; HIF1AN; TYMS; LMO2; PGAM2; DAO; ASNS; UROS; TKT; PAH
    endopeptidase inhibitor activity C5; C3A.3; USP14; SERPINA1A; STFA2; Serpina1c; CST7; RECK; RENBP; CST14B.1
    lipid binding FABP11B; BAIAP2L2B; APOL3; SEC14L4; FABP9; FABP7A; PLEKHA2; PCYT1A; PITPNA; PTGS1
    protein binding BAG5; UBXN1; CREB1; SF3A3; DDX55; COL6A5; LAIR1; EID3; XRCC2; RNF126
    receptor binding HFE; DECR2; UFD1L; CNTFR; CAPRIN2; ADIPOQ; NRG3; ICAM3; NMU; NPFFL

    C3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with C3 here. Most of them are supplied by our site. Hope this information will be useful for your research of C3.

    VSIG4; VSIG4; CD46; d3jib2_staau; IGM; VHL; ASF1B; TGM2; q99ib8-pro_0000045598; q99ib8-pro_0000045601; d-mannose; crlkekhc; IGHM

    Ohta, T; Urayama, K; et al. Eculizumab in the treatment of atypical hemolytic uremic syndrome in an infant leads to cessation of peritoneal dialysis and improvement of severe hypertension. PEDIATRIC NEPHROLOGY 30:603-608(2015).
    Yue, PJ; He, L; et al. Long-term toxicity study of rAd5-hTERTC27 in SD rats and Cynomolgus monkeys by intravenous injection. REGULATORY TOXICOLOGY AND PHARMACOLOGY 71:285-294(2015).

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