| Description : |
Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form the mature protein, which is then further processed to generate numerous peptide products. The C3a peptide, also known as the C3a anaphylatoxin, modulates inflammation and possesses antimicrobial activity. Mutations in this gene are associated with atypical hemolytic uremic syndrome and age-related macular degeneration in human patients. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
187 kDa |
| AA Sequence : |
MGPTSGPSLLLLLLTHLPLALGSPM YSIITPNILRLESEETMVLEAHDAQ GDVPVTVTVHDFPGKKLVLSSEKTV LTPATNHMGNVTFTIPANREFKSEK GRNKFVTVQATFGTQVVEKVVLVSL QSGYLFIQTDKTIYTPGSTVLYRIF TVNHKLLPVGRTVMVNIENPEGIPV KQDSLSSQNQLGVLPLSWDIPELVN MGQWKIRAYYENSPQQVFSTEFEVK EYVLPSFEVIVEPTEKFYYIYNEKG LEVTITARFLYGKKVEGTAFVIFGI QDGEQRISLPESLKRIPIEDGSGEV VLSRKVLLDGVQNLRAEDLVGKSLY VSATVILHSGSDMVQAERSGIPIVT SPYQIHFTKTPKYFKPGMPFDLMVF VTNPDGSPAYRVPVAVQGEDTVQSL TQGDGVAKLSINTHPSQKPLSITVR TKKQELSEAEQATRTMQALPYSTVG NSNNYLHLSVLRTELRPGETLNVNF LLRMDRAHEAKIRYYTYLIMNKGRL LKAGRQVREPGQDLVVLPLSITTDF IPSFRLVAYYTLIGASGQREVVADS VWVDVKDSCVGSLVVKSGQSEDRQP VPGQQMTLKIEGDHGARVVLVAVDK GVFVLNKKNKLTQSKIWDVVEKADI GCTPGSGKDYAGVFSDAGLTFTSSS GQQTAQRAELQCPQPAARRRRSVQL TEKRMDKVGKYPKELRKCCEDGMRE NPMRFSCQRRTRFISLGEACKKVFL DCCNYITELRRQHARASHLGLARSN LDEDIIAEENIVSRSEFPESWLWNV EDLKEPPKNGISTKLMNIFLKDSIT TWEILAVSMSDKKGICVADPFEVTV MQDFFIDLRLPYSVVRNEQVEIRAV LYNYRQNQELKVRVELLHNPAFCSL ATTKRRHQQTVTIPPKSSLSVPYVI VPLKTGLQEVEVKAAVYHHFISDGV RKSLKVVPEGIRMNKTVAVRTLDPE RLGREGVQKEDIPPADLSDQVPDTE SETRILLQGTPVAQMTEDAVDAERL KHLIVTPSGCGEQNMIGMTPTVIAV HYLDETEQWEKFGLEKRQGALELIK KGYTQQLAFRQPSSAFAAFVKRAPS TWLTAYVVKVFSLAVNLIAIDSQVL CGAVKWLILEKQKPDGVFQEDAPVI HQEMIGGLRNNNEKDMALTAFVLIS LQEAKDICEEQVNSLPGSITKAGDF LEANYMNLQRSYTVAIAGYALAQMG RLKGPLLNKFLTTAKDKNRWEDPGK QLYNVEATSYALLALLQLKDFDFVP PVVRWLNEQRYYGGGYGSTQATFMV FQALAQYQKDAPDHQELNLDVSLQL PSRSSKITHRIHWESASLLRSEETK ENEGFTVTAEGKGQGTLSVVTMYHA KAKDQLTCNKFDLKVTIKPAPETEK RPQDAKNTMILEICTRYRGDQDATM SILDISMMTGFAPDTDDLKQLANGV DRYISKYELDKAFSDRNTLIIYLDK VSHSEDDCLAFKVHQYFNVELIQPG AVKVYAYYNLEESCTRFYHPEKEDG KLNKLCRDELCRCAEENCFIQKSDD KVTLEERLDKACEPGVDYVYKTRLV KVQLSNDFDEYIMAIEQTIKSGSDE VQVGQQRTFISPIKCREALKLEEKK HYLMWGLSSDFWGEKPNLSYIIGKD TWVEHWPEEDECQDEENQKQCQDLG AFTESMVVFGCPNTRTRPLEQKLIS EEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
