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Native Rabbit C3 Protein

Cat.No. : C3-01R
Product Overview : Native Rabbit C3 Protein is purified from pooled normal rabbit serum.
  • Specification
  • Gene Information
  • Related Products
Description : Rabbit C3 is purified from pooled normal rabbit serum. C3 is central to the activation of all three pathways of complement activation. Initiation of each pathway generates proteolytic enzyme complexes (C3 convertases) which are bound to the target surface. These enzymes cleave a peptide bond in C3 releasing the anaphylatoxin C3a and activating C3b.
Source : Normal rabbit serum from healthy animals of mixed gender
Species : Rabbit
Form : Frozen liquid
Molecular Mass : ~185kDa (2 chains)
Purity : > 85% by SDS PAGE
Storage : -70°C or below. Avoid freeze/thaw.
Concentration : 1.0 mg/mL (see Certificate of Analysis for actual concentration)
Storage Buffer : 10 mM sodium phosphate, 145 mM NaCl, pH 7.2
Preservative : None, 0.22 µm filtered.
Extinction Coeff. : A280 nm = 10.16 at 1.0 mg/ml for pure C3
Precautions : Use normal precautions for handling animal blood products.
Gene Name : C3 complement C3 [ Oryctolagus cuniculus (rabbit) ]
Official Symbol : C3
Gene ID : 100009121
mRNA Refseq : NM_001082286.1
Protein Refseq : NP_001075755.1
UniProt ID : P12247

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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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Have proteins been found to interact with C3 proteins? 10/26/2019

Yes, a variety of proteins that interact with C3 proteins, including complement receptors, regulatory proteins, inflammatory factors, etc., have been discovered, and they are jointly involved in the regulation and functional execution of C3 proteins.

What is the relationship between C3 protein and infectious diseases? 09/28/2019

C3 protein plays an important role in infectious diseases. It can play an anti-infection role by activating the complement system, directly killing pathogens or enhancing the ability of immune cells to destroy pathogens.

How is the research progress of C3 protein at present? 09/23/2019

Research on C3 protein is going on. At present, it mainly focuses on the analysis of its function and regulatory mechanism, the identification of gene mutations associated with diseases, and the interaction with other complement proteins and immune cells, which provides a theoretical basis for the further development of diagnosis and treatment methods of related diseases.

What is the use of C3 protein in laboratory diagnostics? 05/24/2019

C3 protein can be used as an aid in the diagnosis of certain immune-related diseases. Measuring the level of C3 protein in serum can reflect the activity of the immune system and the degree of inflammation.

What are the effects of post-translational modifications of C3 protein on its function? 04/15/2019

Post-translational modifications of the C3 protein can affect its function. Phosphorylation, cleavage, methylation and other modifications can regulate the activity, stability and interaction ability of C3 proteins.

Have any drug treatments associated with C3 protein been identified? 02/22/2019

Yes, some C3 protein-related drug treatments are under development, including drugs that regulate the degree of C3 protein activation, drugs that inhibit the overactivation of C3 protein, etc.

Customer Reviews (3)

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Reviews
02/23/2022

    Expression efficiency is high. In our experiments, we found that the target protein can be synthesized quickly and effectively.

    01/26/2022

      Activity was not significantly different from the native protein, as expected.

      03/23/2021

        High purity, no obvious impurities.

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