Native Rabbit C3 Protein
Cat.No. : | C3-01R |
Product Overview : | Native Rabbit C3 Protein is purified from pooled normal rabbit serum. |
- Specification
- Gene Information
- Related Products
Description : | Rabbit C3 is purified from pooled normal rabbit serum. C3 is central to the activation of all three pathways of complement activation. Initiation of each pathway generates proteolytic enzyme complexes (C3 convertases) which are bound to the target surface. These enzymes cleave a peptide bond in C3 releasing the anaphylatoxin C3a and activating C3b. |
Source : | Normal rabbit serum from healthy animals of mixed gender |
Species : | Rabbit |
Form : | Frozen liquid |
Molecular Mass : | ~185kDa (2 chains) |
Purity : | > 85% by SDS PAGE |
Storage : | -70°C or below. Avoid freeze/thaw. |
Concentration : | 1.0 mg/mL (see Certificate of Analysis for actual concentration) |
Storage Buffer : | 10 mM sodium phosphate, 145 mM NaCl, pH 7.2 |
Preservative : | None, 0.22 µm filtered. |
Extinction Coeff. : | A280 nm = 10.16 at 1.0 mg/ml for pure C3 |
Precautions : | Use normal precautions for handling animal blood products. |
Gene Name : | C3 complement C3 [ Oryctolagus cuniculus (rabbit) ] |
Official Symbol : | C3 |
Gene ID : | 100009121 |
mRNA Refseq : | NM_001082286.1 |
Protein Refseq : | NP_001075755.1 |
UniProt ID : | P12247 |
Products Types
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◆ Native Protein | ||
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (6)
Ask a questionYes, a variety of proteins that interact with C3 proteins, including complement receptors, regulatory proteins, inflammatory factors, etc., have been discovered, and they are jointly involved in the regulation and functional execution of C3 proteins.
C3 protein plays an important role in infectious diseases. It can play an anti-infection role by activating the complement system, directly killing pathogens or enhancing the ability of immune cells to destroy pathogens.
Research on C3 protein is going on. At present, it mainly focuses on the analysis of its function and regulatory mechanism, the identification of gene mutations associated with diseases, and the interaction with other complement proteins and immune cells, which provides a theoretical basis for the further development of diagnosis and treatment methods of related diseases.
C3 protein can be used as an aid in the diagnosis of certain immune-related diseases. Measuring the level of C3 protein in serum can reflect the activity of the immune system and the degree of inflammation.
Post-translational modifications of the C3 protein can affect its function. Phosphorylation, cleavage, methylation and other modifications can regulate the activity, stability and interaction ability of C3 proteins.
Yes, some C3 protein-related drug treatments are under development, including drugs that regulate the degree of C3 protein activation, drugs that inhibit the overactivation of C3 protein, etc.
Customer Reviews (3)
Write a reviewExpression efficiency is high. In our experiments, we found that the target protein can be synthesized quickly and effectively.
Activity was not significantly different from the native protein, as expected.
High purity, no obvious impurities.
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