ca1
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  • Official Full Name
  • carbonic anhydrase I
  • Background
  • Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA1 is closely linked to CA2 and CA3 genes on chromosome 8, and it encodes a cytosolic protein which is found at the highest level in erythrocytes. Variants of this gene have been described in some populations. Multiple alternatively spliced variants, encoding the same protein, have been identified. Transcript variants of CA1 utilizing alternative polyA_sites have been described in literature.
  • Synonyms
  • CA1; carbonic anhydrase I; carbonic anhydrase 1; Car1; JW0122; CA 1; CA I; CA-I; CAB; CAH1_HUMAN; CAI; CAN; Car 1; Carbonate dehydratase I; Carbonic anhydrase B; Carbonic dehydratase; ECK0125; yadF; OTTHUMP00000227973; OTTHUMP00000227974; OTTHUMP00000227976; OTTHUMP00000227977; OTTHUMP00000227978; OTTHUMP00000227979; OTTHUMP00000227981; Car-1; AW555628
Cat.#:CA1-1347RTag:His
Source (Host):YeastSpecies:Rat
Product nameRecombinant Rat CA1 Protein (2-261 aa), His-tagged
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Cat.#:CA1-375RTag:His|SUMO
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat CA1 Protein (2-261 aa), His-SUMO-tagged
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Cat.#:CA1-0227HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CA1 Protein, GST-Tagged
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Cat.#:CA1-1677HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Carbonic Anhydrase I, His-tagged
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Cat.#:CA1-2505HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Carbonic Anhydrase I, His-tagged
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Cat.#:CA1-10612HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CA1, GST-tagged
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Cat.#:CA1-811HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CA1 Protein
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Cat.#:CAR1-2711MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CAR1 Protein
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Cat.#:CAR1-1131RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CAR1 Protein
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Cat.#:CA1-179HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Carbonic Anhydrase I
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Cat.#:CA1-7917HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human CA1 293 Cell Lysate
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Cat.#:Kit-1936Tag:N/A
Source (Host):Species:
Product nameCAR1 (human) Reporter Assay Kit
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Involved Pathway

CA1 involved in several pathways and played different roles in them. We selected most pathways CA1 participated on our site, such as Nitrogen metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with CA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Nitrogen metabolism
CAR13; Car8; GLUD1B; CAR5A; CA5B; CA1; CA4; GLUD2; CAR1; CA14

Protein Function

CA1 has several biochemical functions, for example, arylesterase activity, carbonate dehydratase activity, hydro-lyase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CA1 itself. We selected most functions CA1 had, and list some proteins which have the same functions with CA1. You can find most of the proteins on our site.
Function
Related Protein
Function arylesterase activity
Related Protein C20orf3; CA2; PON1; Car2; PON2; CAR1; CA1; PON3; APMAP
Function carbonate dehydratase activity
Related Protein Car8; Car12; CA4A; CA15C; Car4; CA13; Car2; CA6; CA8; CA9
Function hydro-lyase activity
Related Protein L3HYPDH; CAR1; HIBCH; CA1
Function protein binding
Related Protein BARHL2; PRKX; PRPF8; OTUB1; CCNK; BCL6; KCTD5; GRB10; RASL11A; FAM167A
Function zinc ion binding
Related Protein NRD1B; ANKIB1; AGBL1; APIP; KMT2E; ZFAND5; CXXC4; TRIM3; XAF1; PHF7

Interacting Protein

CA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CA1.
TFCP2; HSD17B7; MAPK6

CA1 Related Articles

Czeh, B; Varga, ZKK; et al. Chronic Stress Reduces the Number of GABAergic Interneurons in the Adult Rat Hippocampus, Dorsal-Ventral and Region-Specific Differences. HIPPOCAMPUS 25:393-405(2015).
Wang, WC; Cheng, CF; et al. Immunohistochemical Localization of DPP10 in Rat Brain Supports the Existence of a Kv4/KChIP/DPPL Ternary Complex in Neurons. JOURNAL OF COMPARATIVE NEUROLOGY 523:608-628(2015).