camk4
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  • Official Full Name
  • calcium/calmodulin-dependent protein kinase IV
  • Background
  • The product of this gene belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This enzyme is a multifunctional serine/threonine protein kinase with limited tissue distribution, that has been implicated in transcriptional regulation in lymphocytes, neurons and male germ cells.
  • Synonyms
  • CAMK4; calcium/calmodulin-dependent protein kinase IV; calcium/calmodulin-dependent protein kinase type IV; brain Ca++ calmodulin dependent protein kinase type IV; calcium/calmodulin dependent protein kinase type IV catalytic chain; CAM kinase IV; CAM kin
Cat.#:CAMK4-379RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat CAMK4 Protein (1-474 aa), His-tagged
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Cat.#:CAMK4-0336HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CAMK4 Protein, GST-Tagged
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Cat.#:CAMK4-2493HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human CAMK4 Protein, MYC/DDK-tagged
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Cat.#:CAMK4-26208THTag:
Source (Host):Species:Human
Product nameRecombinant Human CAMK4
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Cat.#:CAMK4-956HTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human CAMK4, GST tagged
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Cat.#:Camk4-477MTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse Camk4, Gly & Pro tagged
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Cat.#:Camk4-7403MTag:His/GST
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse Camk4, His & GST tagged
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Cat.#:CAMK4-1106RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CAMK4 Protein
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Cat.#:CAMK4-3271CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CAMK4
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Cat.#:CAMK4-2379ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CAMK4
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Cat.#:CAMK4-1379HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Calcium/Calmodulin-Dependent Protein Kinase IV, His-tagged
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Cat.#:CAMK4-268HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human CAMK4, GST-tagged, Active
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Cat.#:CAMK4-1373HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human CAMK4 (Active), GST-tagged
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Cat.#:CAMK4-001MCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse CAMK4 cell lysate
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Involved Pathway

CAMK4 involved in several pathways and played different roles in them. We selected most pathways CAMK4 participated on our site, such as Calcium signaling pathway, cAMP signaling pathway, Osteoclast differentiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with CAMK4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Calcium signaling pathway
CHRM2A; BDKRB1; CAMK2D; ADCY1A; EDNRA; TNNC1; P2RX2; LTB4R2; DRD1A; CALM1
cAMP signaling pathway
ARAP3; SLC9A1; ATP1A3; GHRL; CNGA4; PRKACG; RAC3; CNGA2; PIK3R1; BDNF
Osteoclast differentiation
MAPK9; FOSL1; FCGR1A; PPP3CB; TREM2; PIK3CA; IL1R1; MAP3K7; CSF1R; CALCR
Long-term potentiation
GRIA2; CALM2; PPP3CB; CAMK2B; CAMK2D; ATF4; CALML5; RPS6KA3; GRIA1; PRKCA
Neurotrophin signaling pathway
RAPGEF1; RPS6KA3; MAPK12; CAMK2A; BAD; AKT1; RAP1B; CALM2; RPS6KA2; Fasl
Cholinergic synapse
CHRNA6; KCNJ6; PRKACA; KCNQ2; CAMK2G; AKT2; KCNJ14; CAMK2A; GNAQ; PRKACG
Oxytocin signaling pathway
CALML3; MAPK3; MAP2K2; PPP3R2; PLA2G4D; CAMK1G; CD38; PPP3CC; CACNA2D4; PRKAB2
Aldosterone synthesis and secretion
CREB3L4; PLCB1; AGTR1A; ITPR1; ADCY9; MC2R; LDLR; ATF4; GNAQ; GNA11
Amphetamine addiction
PRKCB; CAMK2A; SLC18A1; PPP3CB; CALM3; MAOA; GRIA2; SIRT1; CREB5; PRKACG
Alcoholism
CAMKK1; H3F3C; HIST1H2AM; GNG12; GNG2; GRB2; HIST1H2BG; CREB3; HIST1H2BD; H3F3B

Protein Function

CAMK4 has several biochemical functions, for example, ATP binding, calcium-dependent protein serine/threonine kinase activity, calmodulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CAMK4 itself. We selected most functions CAMK4 had, and list some proteins which have the same functions with CAMK4. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein UBE2L3B; ACSS3; PGS1; TESK2; EPHB4; SMOK2B; ABCA4; HELZ2; ASS1; KIF17
Function calcium-dependent protein serine/threonine kinase activity
Related Protein CAMK4; MAPKAPK5; MKNK2A; MKNK2; DCX; CAMK1GB; CAMK1GA; MAPKAPK2A; MKNK1; MKNK2B
Function calmodulin binding
Related Protein SPA17; ASPM; PHKA1; CAMK2D2; KCNN3; SRY; MARCKS; KCNQ1; MYO1D; UPF3B
Function calmodulin-dependent protein kinase activity
Related Protein CAMK2B; CAMK1GB; PTK2B; MAPKAPK2A; DCX; NETO2; MAPKAPK2; SLC14A2; MAPKAPK2B; CAMK2G1

Interacting Protein

CAMK4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CAMK4 here. Most of them are supplied by our site. Hope this information will be useful for your research of CAMK4.
HSP90AB1

CAMK4 Related Articles

Sugiyama, Y; Murao, K; et al. Calcium/calmodulin-dependent protein kinase IV involvement in the pathophysiology of glucotoxicity in rat pancreatic beta-cells. METABOLISM-CLINICAL AND EXPERIMENTAL 60:145-153(2011).
Blanquet, PR; Mariani, J; et al. Temporal assessment of histone H3 phospho-acetylation and casein kinase 2 activation in dentate gyms from ischemic rats. BRAIN RESEARCH 1302:10-20(2009).