CARD8
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Official Full Name
caspase recruitment domain family, member 8 -
Overview
The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene. -
Synonyms
CARD8;caspase recruitment domain family, member 8;caspase recruitment domain-containing protein 8;CARDINAL;Dakar;KIAA0955;NDPP;TUCAN;apoptotic protein NDPP1;CARD inhibitor of NF-kappaB-activating ligands;tumor up-regulated CARD-containing antago
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CARD8-10721H | Recombinant Human CARD8, GST-tagged | E.coli | Human | GST | 10-341a.a. | |
| CARD8-0396H | Recombinant Human CARD8 Protein, GST-Tagged | Wheat Germ | Human | GST |
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| CARD8-283HCL | Recombinant Human CARD8 cell lysate | Human | Non |
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| CARD8-2886HF | Recombinant Full Length Human CARD8 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 392 amino acids |
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Involved Pathway
CARD8 involved in several pathways and played different roles in them. We selected most pathways CARD8 participated on our site, such as NOD-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CARD8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| NOD-like receptor signaling pathway | HSP90AA1.2,MAPK8A,ERBB2IP,CARD9,TNF,MAPK13,MAP3K7IP3,CCL2,NAIP7,IL18 |
Protein Function
CARD8 has several biochemical functions, for example, NACHT domain binding,cysteine-type endopeptidase activator activity involved in apoptotic process,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CARD8 itself. We selected most functions CARD8 had, and list some proteins which have the same functions with CARD8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cysteine-type endopeptidase activator activity involved in apoptotic process | NOD1,MAPK9,BCL2L13,NLRP1,NLRP12,RPS27L,CASP1,BAD,PYCARD,CTSC |
| NACHT domain binding | TRIM16 |
| protein homodimerization activity | GTF2A2,PRPS1,HLA-G,PRMT8,JAM3,CRYBB2,CRTAM,FGFR2,CR2,TBX18 |
| protein binding | PPM1F,KDR,HHLA3,OSR2,NUP62L,NPHP3,RAB24,FAM162A,CDK5R2,CCT6A |
Interacting Protein
CARD8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CARD8 here. Most of them are supplied by our site. Hope this information will be useful for your research of CARD8.
FHL2;CASP9;IKBKG;lpd;tuf;ypgR
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References
- Vasseur, F; Sendid, B; et al. The CARD8 p.C10X mutation associates with a low anti-glycans antibody response in patients with Crohn's disease. BMC MEDICAL GENETICS 14:-(2013).
- Ben Hamad, M; Cornelis, F; et al. Association study of CARD8 (p.C10X) and NLRP3 (p.Q705K) variants with rheumatoid arthritis in French and Tunisian populations. INTERNATIONAL JOURNAL OF IMMUNOGENETICS 39:131-136(2012).
