Recombinant Human CARD8 Protein, GST-Tagged

• Cat.No.: CARD8-0396H
• Product Overview: Human CARD8 full-length ORF (AAH56891.1, 1 a.a. - 392 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2010]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 70.4 kDa
• AA Sequence: MEKKECPEKSSSSEEELPRRDSGSS RNIDASKLIRLQGSRKLLVDNSIRE LQYTKTGIFFQAEACVTNDTVYREL PCVSETLCDISHFFQEDDETEAEPL LFRAVPECQLSGGDIPSVSEEQESS EGQDSGDICSEENQIVSSYASKVCF EIEEDYKNRQFLGPEGNVDVELIDK STNRYSVWFPTAGWYLWSATGLGFL VRDEVTVTIAFGSWSQHLALDLQHH EQWLVGGPLFDVTAEPEEAVAEIHL PHSISLQAGEVDVSWFLVAHFKNEG MVLEHPARVEPFYAVLESPSFSLMG ILLRIASGTRLSIPITSNTLIYYHP HPEDIKFHLYLVPSDALLTKAIDDE EDRFHGVRLQTSPPMEPLNFGSSYI VSNSANLKVMPKWISSL
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: CARD8 caspase recruitment domain family, member 8 [ Homo sapiens ]
• Official Symbol: CARD8
• Synonyms: CARD8; caspase recruitment domain family, member 8; caspase recruitment domain-containing protein 8; CARDINAL; Dakar; KIAA0955; NDPP; TUCAN; apoptotic protein NDPP1; CARD inhibitor of NF-kappaB-activating ligands; tumor up-regulated CARD-containing antagonist of CASP9; tumor up-regulated CARD-containing antagonist of caspase nine; DACAR; DAKAR; NDPP1; FLJ18119; FLJ18121; MGC57162; DKFZp779L0366
• Gene ID: 22900
• mRNA Refseq: NM_001184900
• Protein Refseq: NP_001171829
• MIM: 609051
• UniProt ID: Q9Y2G2