| Official Full Name | caspase 8, apoptosis-related cysteine peptidase |
| Background | This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq, Jul 2008] |
| Synonyms | CASP8; caspase 8, apoptosis-related cysteine peptidase; CAP4; MACH; MCH5; FLICE; ALPS2B; Casp-8; caspase-8; FADD-like ICE; MACH-alpha-1/2/3 protein; apoptotic protease Mch-5; MACH-beta-1/2/3/4 protein; apoptotic cysteine protease; ICE-like apoptotic protease 5; MORT1-associated ced-3 homolog; FADD-homologous ICE/CED-3-like protease; caspase 8, apoptosis-related cysteine protease |
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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CASP8 involved in several pathways and played different roles in them. We selected most pathways CASP8 participated on our site, such as p signaling pathway, Apoptosis, Toll-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CASP8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| p signaling pathway | RPRM; PTEN; RCHY1; RPRMA; Casp3; MDM2; CCNB3; CCND3; BID; MDM4 |
| Apoptosis | GZME; DBNLB; CAPN1B; PKP1; PPP3CCB; BCAP31; CASP2; SATB1; BIDA; MYC |
| Toll-like receptor signaling pathway | PIK3R5; CXCL9; IKBKE; MAPK11; IFNA5; TLR5B; PIK3R3A; TBK1; MAPK10; IL8L1 |
| NOD-like receptor signaling pathway | ERBB2IP; HSP90AA1.2; BIRC3; IL18; NLRC4; MAPK9; NLRP1; CARD9; PYDC1; IL-8 |
| RIG-I-like receptor signaling pathway | OTUD5A; MAPK8B; MAPK14A; ATG5; IRF7; MAPK12B; RIPK1; MAPK12; IRF3; NT5C3 |
| TNF signaling pathway | IKBKG; PIK3R1; RPS6KA4; ATF4; PIK3CG; PIK3R3; VEGFC; SOCS3; ICAM1; PIK3R5 |
| Non-alcoholic fatty liver disease (NAFLD) | NDUFS3; DDIT3; UQCR10; CDC42; TGFB1; MAPK10; NDUFB8; ATF4; NDUFC2; PIK3CG |
| Alzheimers disease | CAPN1; MT-ATP6; NDUFA8; APBB1; COX5B; UQCRB; NDUFA4L2; SDHD; AKR1C1; ATP5H |
| Huntingtons disease | CREB3L2; COX7B2; COX7C; TBPL2; SLC25A5; mt-Atp8; PPIF; NDUFV1; SOD1; COX4I1 |
| Legionellosis | HSPA6; HSPD1; CASP7; HSPA1B; NFKB1; TLR4; NFKBIA; TLR5; NAIP6; TLR2 |
| Chagas disease (American trypanosomiasis) | CCL5; CCL2; MAPK13; GNAQ; MAPK10; SMAD3; CD3E; MAP2K4; IL6; MAPK9 |
| Toxoplasmosis | IL12A; HSPA1A; GNAI2; LDLR; LY96; HLA-DPB1; MAP3K7; XIAP; PIK3R2; HLA-DRA |
| Tuberculosis | RAB7; VDR; NFYC; PPP3CA; SRC; ITGB2; CASP8; ATP6V0D2; ITGAX; NFYA |
| Hepatitis B | NFATC1; CCNA1; CCNE2; GRB2; CCND1; MAPK8; IFNA14; Ifna11; TGFB1; STAT3 |
| Herpes simplex infection | FASLG; GTF2IRD1; TBK1; SRPK1B; CASP3A; IFNA4; PVRL2; TRP53; MHC1UXA2; PER1A |
| Pathways in cancer | ARHGEF1; CBL; PIK3R2; GLI2; SMAD4; SOS1; SLC2A1; HGF; FGF13; FZD6 |
| Viral carcinogenesis | YWHAG; MAD1L1; LYN; ACTN4; UBE3A; DLG1; RAC1; CCNE2; DNAJA3; YWHAZ |
| Viral myocarditis | HLA-DRB3; HLA-DQA2; FYN; CCND1; H2-AB1; HLA-DMA; RAC3; ACTB; Casp3; MYH7 |
CASP8 has several biochemical functions, for example, cysteine-type endopeptidase activity, cysteine-type endopeptidase activity involved in apoptotic process, cysteine-type endopeptidase activity involved in apoptotic signaling pathway. Some of the functions are cooperated with other proteins, some of the functions could acted by CASP8 itself. We selected most functions CASP8 had, and list some proteins which have the same functions with CASP8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cysteine-type endopeptidase activity | CTSBB; CTSZ; USP19; CASPB; USP49; CTSH; CASP10; USP40; PDIA3; CASP6 |
| cysteine-type endopeptidase activity involved in apoptotic process | Casp3; CLC; CASP8 |
| cysteine-type endopeptidase activity involved in apoptotic signaling pathway | CASP8L1; CASP14; CASP9; CASP2; CFLARA; CFLAR; CASP8; CASP10 |
| cysteine-type peptidase activity | OTUD6B; ALG13; SENP3B; CAPN1B; CASP3A; CASP3B; PGPEP1; Casp3; BLMH; CAPN2A |
| death effector domain binding | NOL3; CASP8L1; CFLAR; FADD; CASP8; CASP10; CFLARA |
| death receptor binding | CASP8; Fasl; PIDD1; TMBIM1; Casp3; TNFSF15; FEM1B; CFLAR; NOL3; PRDM4 |
| peptidase activity | REN; ADAM25; PRSS59.2; CTSG; PSMB9A; Shh; CTSBB; CTRC; PSMA6B; ELA2L |
| protein binding | NCAM1A; DDO; DPP4; SEPT11; PRDX3; FAM72A; MAPK7; IL1R2; RHOT1; FBXO45 |
| protein complex binding | MLC1; ERCC6; VHLL; Apba1; PDX1; SIX2; LEPRE1; NDUFA4; PEX1; CCNE1 |
| protein heterodimerization activity | HIST4H4; BAD; SPNA1; CEBPB; TAP1; TAF6; SCGB2A1; TGFB1; Fzd4; H2AFY2 |
| scaffold protein binding | GRIN2A; TREM2; SHANK3; MDM2; CRIPT; MAP2K2; ADCY6; KRT15; NCK2; NLGN4X |
| tumor necrosis factor receptor binding | TRAF3; TNFSF10L4; FASLG; LTA; TRAF1; TRAF2; TNFSF11; CD40LG; TNFSF8; TRADD |
| ubiquitin protein ligase binding | PTPN22; OTUB1; CDC34B; PA2G4; EIF4E2; CUL3B; XRCC5; HDAC6; DLG3; WASH1 |
CASP8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CASP8 here. Most of them are supplied by our site. Hope this information will be useful for your research of CASP8.
FADD
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