casp8
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  • Official Full Name
  • caspase 8, apoptosis-related cysteine peptidase
  • Background
  • This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq, Jul 2008]
  • Synonyms
  • CASP8; caspase 8, apoptosis-related cysteine peptidase; CAP4; MACH; MCH5; FLICE; ALPS2B; Casp-8; caspase-8; FADD-like ICE; MACH-alpha-1/2/3 protein; apoptotic protease Mch-5; MACH-beta-1/2/3/4 protein; apoptotic cysteine protease; ICE-like apoptotic protease 5; MORT1-associated ced-3 homolog; FADD-homologous ICE/CED-3-like protease; caspase 8, apoptosis-related cysteine protease
Cat.#:Casp8-1645MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Caspase 8
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Cat.#:CASP8-147HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CASP8 Protein, His-tagged
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Cat.#:CASP8-26606THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CASP8
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Cat.#:CASP8-26HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CASP8, His-tagged
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Cat.#:CASP8-7828HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CASP8 protein, His & T7-tagged
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Cat.#:CASP8-7829HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CASP8 protein, His-tagged
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Cat.#:CASP8-2756MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CASP8 Protein
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Cat.#:Casp8-7830MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Casp8 protein, His & T7-tagged
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Cat.#:Casp8-7831MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Casp8 protein, His & T7-tagged
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Cat.#:CASP8-1146RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CASP8 Protein
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Cat.#:Casp8-7832RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Casp8 protein, His & T7-tagged
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Cat.#:CASP8-6161CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CASP8
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Cat.#:CASP8-9059ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CASP8
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Cat.#:CASP8-7827CTag:His
Source (Host):E. coliSpecies:Cattle
Product nameRecombinant Cattle CASP8 protein, His-tagged
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Cat.#:CASP8-404HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Caspase 8, Apoptosis-Related Cysteine Peptidase
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Cat.#:CASP8-7829HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CASP8 293 Cell Lysate
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Cat.#:CASP8-7830HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CASP8 293 Cell Lysate
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Cat.#:CASP8-7831HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CASP8 293 Cell Lysate
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Involved Pathway

CASP8 involved in several pathways and played different roles in them. We selected most pathways CASP8 participated on our site, such as p signaling pathway, Apoptosis, Toll-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CASP8 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
p signaling pathway
CDK1; CASP9; CCNB2; FAS; PPM1DB; CCND2; CCNG1; BAI1; GADD45AA; CD82A
Apoptosis
SPNA2; GAS2; BCL2A; CASP10; ENDOG; GZME; DNM1L; PKP1; HELLS; CASP7
Toll-like receptor signaling pathway
RIPK1L; MAP2K7; RIPK1; TLR3; FADD; RAC1; STAT1B; TLR1LA; IL1B; NFKBIAB
NOD-like receptor signaling pathway
PSTPIP1B; IKBKB; IL6; IL8L2; PYDC1; MAPK8; MAPK8B; ERBB2IP; CASP8; IL8L1
RIG-I-like receptor signaling pathway
IFNW1; TMEM173; TP-1; IL8L2; IFNA1; CXCL8B.3; IRF3; IL8L1; IFNA3; IFNA14
TNF signaling pathway
FOS; MAPK12; Casp3; MAPK11; CCL5; TNFAIP3; MAP2K3; MAPK3; MMP14; AKT1
Non-alcoholic fatty liver disease (NAFLD)
SREBF1; COX6A2; NDUFV1; AKT1; PPARA; ATF4; NDUFA6; NDUFB4; NDUFA10; UQCR10
Alzheimers disease
GSK3B; NOS1; NDUFC2-KCTD14; NDUFB1; CALM4; MAPT; BID; GAPDH; NDUFA3; NDUFA9
Huntingtons disease
RCOR1; NDUFS2; REST; COX4I2; NDUFB9; CASP9; Casp3; NDUFS7; DNAH14; DCTN1
Legionellosis
HSPA1L; SEC22B; IL12A; HSPD1; IL12B; CASP1; CXCL1; RAB1A; NAIP6; TLR5
Chagas disease (American trypanosomiasis)
CD3E; CD3D; SERPINE1; CFLAR; TGFB3; GNAQ; MAPK10; SMAD3; C3; IL12A; CD3E
Toxoplasmosis
Toxoplasma Gondii Microneme Protein MIC3; BAD; PIK3CG; MAPK10; PIK3R1; MAP2K6; IFNG; Casp3; HLA-DRB5; GNAI2
Tuberculosis
CASP8; HLA-DRB1; TGFB1; FCGR1; IL12B; HLA-DRB4; CALM2; MAPK12; IFNA10; IL1B
Hepatitis B
HRAS; CYCS; TLR2; MAPK9; NFKBIA; IKBKG; STAT4; ELK1; MAP2K1; PRKCG
Herpes simplex infection
IRF9; C3A.3; JAK2B; IFNA14; IFNA21; TAF5L; IFIH1; FB06F03; GTF2IRD1; EIF2AK3
Pathways in cancer
FGF12; WNT5B; GSK3B; GNB1; PIK3R1; PLCB4; FZD5; LPAR3; NOS2; BDKRB2
Viral carcinogenesis
GTF2H2C_2; HDAC9; TRAF3; SKP2; BAK1; RBL1; NRAS; PIK3CB; RBPJL; ATP6V0D2
Viral myocarditis
ABL1; ITGB2; SGCD; SGCA; HLA-F; HLA-DRA; HLA-DOB; ITGAL; Casp3; HLA-E

Protein Function

CASP8 has several biochemical functions, for example, cysteine-type endopeptidase activity, cysteine-type endopeptidase activity involved in apoptotic process, cysteine-type endopeptidase activity involved in apoptotic signaling pathway. Some of the functions are cooperated with other proteins, some of the functions could acted by CASP8 itself. We selected most functions CASP8 had, and list some proteins which have the same functions with CASP8. You can find most of the proteins on our site.
Function
Related Protein
Function cysteine-type endopeptidase activity
Related Protein Ctsl; LGMN; USP43A; USP18; CTSL2; DUB1; USP4; USP13; USP12A; USP48
Function cysteine-type endopeptidase activity involved in apoptotic process
Related Protein CASP8; Casp3; CLC
Function cysteine-type endopeptidase activity involved in apoptotic signaling pathway
Related Protein CASP8L1; CASP14; CASP10; CASP9; CFLARA; CASP8; CASP2; CFLAR
Function cysteine-type peptidase activity
Related Protein ALG13; USPL1; BLMH; OTULIN; DUB1; CAPN12; CLCA3; CTSK; CTSM; CASP3A
Function death effector domain binding
Related Protein CASP8L1; CFLARA; CASP10; NOL3; CASP8; CFLAR; FADD
Function death receptor binding
Related Protein TNFSF15; Fasl; PIDD1; CFLAR; Casp3; NOL3; TMBIM1; FEM1B; FASLG; RIPK1
Function peptidase activity
Related Protein GM5077; PSMA6B; UFSP2; CLPP; Shh; ADAM1B; METAP2B; HE1A; PSMB8F; CAPN1A
Function protein binding
Related Protein BCCIP; NUP107; ATXN2; SRM; OLIG1; PAX3; EEF1E1; KRT18; FAM127A; PAX2
Function protein complex binding
Related Protein ST13; THRA; MLKL; UQCRC2; GNB4; PPP4C; RBM10; KLHL8; DISC1; RRAS
Function protein heterodimerization activity
Related Protein SOX14; BCL2A; PPP2R1A; SOX5; PAFAH1B2; HIST1H2B7; DDX1; IKZF1; MCL1; BMP2
Function scaffold protein binding
Related Protein MAP2K2; IKBKB; CACNA1G; KRT5; TREM1; NLGN4Y; CIT; DSP; HOMER1; P2RY1
Function tumor necrosis factor receptor binding
Related Protein TNFSF15; Fasl; TRAF3; TNFSF10; TNFSF14; TRAF2; FASLG; BRE; TNFSF12; TNF
Function ubiquitin protein ligase binding
Related Protein ATXN3; TMBIM6; MAGEA2B; ACVR1B; TMEM189; TCP1; TRAF6; SMAD5; SMAD3; MID1

Interacting Protein

CASP8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CASP8 here. Most of them are supplied by our site. Hope this information will be useful for your research of CASP8.
FADD

CASP8 Related Articles

Shaw, BE; Lee, F; et al. Caspase-8 polymorphisms result in reduced Alemtuzumab-induced T-cell apoptosis and worse survival after transplantation. BONE MARROW TRANSPLANTATION 50:237-243(2015).
Hu, Y; Liu, HX; et al. Transcriptome profiling and genome-wide DNA binding define the differential role of fenretinide and all-trans RA in regulating the death and survival of human hepatocellular carcinoma Huh7 cells. BIOCHEMICAL PHARMACOLOGY 85:1007-1017(2013).