CASP8 Protein, caspase 8, apoptosis-related cysteine peptidase


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Official Full Name caspase 8, apoptosis-related cysteine peptidase
Background This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq, Jul 2008]
Synonyms CASP8; caspase 8, apoptosis-related cysteine peptidase; CAP4; MACH; MCH5; FLICE; ALPS2B; Casp-8; caspase-8; FADD-like ICE; MACH-alpha-1/2/3 protein; apoptotic protease Mch-5; MACH-beta-1/2/3/4 protein; apoptotic cysteine protease; ICE-like apoptotic protease 5; MORT1-associated ced-3 homolog; FADD-homologous ICE/CED-3-like protease; caspase 8, apoptosis-related cysteine protease
    • Species :
    • Cattle
    • Chicken
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Tag :
    • His
    • T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CASP8-26606TH Recombinant Human CASP8 Protein E.coli N/A
    Human CASP8-147H Recombinant Human CASP8 Protein, His-tagged E.coli His
    Human CASP8-26H Recombinant Human CASP8, His-tagged E.coli His
    Human CASP8-404H Recombinant Human Caspase 8, Apoptosis-Related Cysteine Peptidase E.coli N/A
    Human CASP8-7828H Recombinant Human CASP8 protein, His & T7-tagged E.coli His/T7
    Human CASP8-7829H Recombinant Human CASP8 protein, His-tagged E.coli His
    Human CASP8-7829HCL Recombinant Human CASP8 293 Cell Lysate HEK293 N/A
    Human CASP8-7830HCL Recombinant Human CASP8 293 Cell Lysate HEK293 N/A
    Human CASP8-7831HCL Recombinant Human CASP8 293 Cell Lysate HEK293 N/A
    Mouse Casp8-1645M Recombinant Mouse Caspase 8 E.coli N/A
    Mouse CASP8-2756M Recombinant Mouse CASP8 Protein Mammalian Cell His
    Mouse Casp8-7830M Recombinant Mouse Casp8 protein, His & T7-tagged E.coli His/T7
    Mouse Casp8-7831M Recombinant Mouse Casp8 protein, His & T7-tagged E.coli His/T7
    Rat CASP8-1146R Recombinant Rat CASP8 Protein Mammalian Cell His
    Rat Casp8-7832R Recombinant Rat Casp8 protein, His & T7-tagged E.coli His/T7
    Chicken CASP8-6161C Recombinant Chicken CASP8 Mammalian Cell His
    Zebrafish CASP8-9059Z Recombinant Zebrafish CASP8 Mammalian Cell His
    Cattle CASP8-7827C Recombinant Cattle CASP8 protein, His-tagged E.coli His

    CASP8 involved in several pathways and played different roles in them. We selected most pathways CASP8 participated on our site, such as p signaling pathway, Apoptosis, Toll-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CASP8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    p signaling pathway RPRM; PTEN; RCHY1; RPRMA; Casp3; MDM2; CCNB3; CCND3; BID; MDM4
    Toll-like receptor signaling pathway PIK3R5; CXCL9; IKBKE; MAPK11; IFNA5; TLR5B; PIK3R3A; TBK1; MAPK10; IL8L1
    NOD-like receptor signaling pathway ERBB2IP; HSP90AA1.2; BIRC3; IL18; NLRC4; MAPK9; NLRP1; CARD9; PYDC1; IL-8
    RIG-I-like receptor signaling pathway OTUD5A; MAPK8B; MAPK14A; ATG5; IRF7; MAPK12B; RIPK1; MAPK12; IRF3; NT5C3
    TNF signaling pathway IKBKG; PIK3R1; RPS6KA4; ATF4; PIK3CG; PIK3R3; VEGFC; SOCS3; ICAM1; PIK3R5
    Non-alcoholic fatty liver disease (NAFLD) NDUFS3; DDIT3; UQCR10; CDC42; TGFB1; MAPK10; NDUFB8; ATF4; NDUFC2; PIK3CG
    Alzheimers disease CAPN1; MT-ATP6; NDUFA8; APBB1; COX5B; UQCRB; NDUFA4L2; SDHD; AKR1C1; ATP5H
    Huntingtons disease CREB3L2; COX7B2; COX7C; TBPL2; SLC25A5; mt-Atp8; PPIF; NDUFV1; SOD1; COX4I1
    Legionellosis HSPA6; HSPD1; CASP7; HSPA1B; NFKB1; TLR4; NFKBIA; TLR5; NAIP6; TLR2
    Chagas disease (American trypanosomiasis) CCL5; CCL2; MAPK13; GNAQ; MAPK10; SMAD3; CD3E; MAP2K4; IL6; MAPK9
    Toxoplasmosis IL12A; HSPA1A; GNAI2; LDLR; LY96; HLA-DPB1; MAP3K7; XIAP; PIK3R2; HLA-DRA
    Tuberculosis RAB7; VDR; NFYC; PPP3CA; SRC; ITGB2; CASP8; ATP6V0D2; ITGAX; NFYA
    Hepatitis B NFATC1; CCNA1; CCNE2; GRB2; CCND1; MAPK8; IFNA14; Ifna11; TGFB1; STAT3
    Herpes simplex infection FASLG; GTF2IRD1; TBK1; SRPK1B; CASP3A; IFNA4; PVRL2; TRP53; MHC1UXA2; PER1A
    Pathways in cancer ARHGEF1; CBL; PIK3R2; GLI2; SMAD4; SOS1; SLC2A1; HGF; FGF13; FZD6
    Viral carcinogenesis YWHAG; MAD1L1; LYN; ACTN4; UBE3A; DLG1; RAC1; CCNE2; DNAJA3; YWHAZ
    Viral myocarditis HLA-DRB3; HLA-DQA2; FYN; CCND1; H2-AB1; HLA-DMA; RAC3; ACTB; Casp3; MYH7

    CASP8 has several biochemical functions, for example, cysteine-type endopeptidase activity, cysteine-type endopeptidase activity involved in apoptotic process, cysteine-type endopeptidase activity involved in apoptotic signaling pathway. Some of the functions are cooperated with other proteins, some of the functions could acted by CASP8 itself. We selected most functions CASP8 had, and list some proteins which have the same functions with CASP8. You can find most of the proteins on our site.

    Function Related Protein
    cysteine-type endopeptidase activity CTSBB; CTSZ; USP19; CASPB; USP49; CTSH; CASP10; USP40; PDIA3; CASP6
    cysteine-type endopeptidase activity involved in apoptotic process Casp3; CLC; CASP8
    cysteine-type endopeptidase activity involved in apoptotic signaling pathway CASP8L1; CASP14; CASP9; CASP2; CFLARA; CFLAR; CASP8; CASP10
    cysteine-type peptidase activity OTUD6B; ALG13; SENP3B; CAPN1B; CASP3A; CASP3B; PGPEP1; Casp3; BLMH; CAPN2A
    death effector domain binding NOL3; CASP8L1; CFLAR; FADD; CASP8; CASP10; CFLARA
    death receptor binding CASP8; Fasl; PIDD1; TMBIM1; Casp3; TNFSF15; FEM1B; CFLAR; NOL3; PRDM4
    peptidase activity REN; ADAM25; PRSS59.2; CTSG; PSMB9A; Shh; CTSBB; CTRC; PSMA6B; ELA2L
    protein binding NCAM1A; DDO; DPP4; SEPT11; PRDX3; FAM72A; MAPK7; IL1R2; RHOT1; FBXO45
    protein complex binding MLC1; ERCC6; VHLL; Apba1; PDX1; SIX2; LEPRE1; NDUFA4; PEX1; CCNE1
    protein heterodimerization activity HIST4H4; BAD; SPNA1; CEBPB; TAP1; TAF6; SCGB2A1; TGFB1; Fzd4; H2AFY2
    scaffold protein binding GRIN2A; TREM2; SHANK3; MDM2; CRIPT; MAP2K2; ADCY6; KRT15; NCK2; NLGN4X
    tumor necrosis factor receptor binding TRAF3; TNFSF10L4; FASLG; LTA; TRAF1; TRAF2; TNFSF11; CD40LG; TNFSF8; TRADD
    ubiquitin protein ligase binding PTPN22; OTUB1; CDC34B; PA2G4; EIF4E2; CUL3B; XRCC5; HDAC6; DLG3; WASH1

    CASP8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CASP8 here. Most of them are supplied by our site. Hope this information will be useful for your research of CASP8.


    Shaw, BE; Lee, F; et al. Caspase-8 polymorphisms result in reduced Alemtuzumab-induced T-cell apoptosis and worse survival after transplantation. BONE MARROW TRANSPLANTATION 50:237-243(2015).
    Hu, Y; Liu, HX; et al. Transcriptome profiling and genome-wide DNA binding define the differential role of fenretinide and all-trans RA in regulating the death and survival of human hepatocellular carcinoma Huh7 cells. BIOCHEMICAL PHARMACOLOGY 85:1007-1017(2013).

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